The APC gene encodes a large protein with multiple cellular functions and interactions, including roles in signal transduction in the ...

APC gene is an autosomal recessive tumor gene capable of somatic mutations that can cause production of small, defective and non-functional proteins, these ...

The APC gene encodes a multidomain protein that plays a major role in tumor suppression by antagonizing the WNT (see WNT1; 164820) signaling pathway.

People with mutations in the APC gene have familial adenomatous polyposis (FAP) or attenuated FAP (AFAP). Individuals with AFAP typically have fewer polyps, ...

(3) most identified point mutations in the APC gene are transitions from cytosine to other nucleotides. (4) the location of germline mutations tends to correlate ...

Summary. The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers ...

Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role in ...

APC (APC Regulator Of WNT Signaling Pathway) is a Protein Coding gene. Diseases associated with APC include Familial Adenomatous Polyposis 1 and ...

The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts ...