Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever with a high mortality rate in humans, which is caused ...ArticlesGuidoPoliVita-SaluteSanRaffaeleUniversity,ItalyMorganeBomselCentreNationaldelaRechercheScientifique(CNRS),FranceEdanaCassolCarletonUniversity,CanadaTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionResultsDiscussionMaterialsandMethodsEthicsStatementAuthorContributionsFundingConflictofInterestStatementSupplementaryMaterialReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataORIGINALRESEARCHarticleFront.Immunol.,15May2019|https://doi.org/10.3389/fimmu.2019.01095SevereFeverWithThrombocytopeniaSyndromeVirus-InducedMacrophageDifferentiationIsRegulatedbymiR-146LiZhang1†,YuxuanFu1†‡,HuanruWang1,YajieGuan1,WeiwenZhu2,MengdiGuo1,NanZheng1andZhiweiWu1,3,4*1CenterforPublicHealthResearch,MedicalSchool,NanjingUniversity,Nanjing,China2JiangsuKeyLaboratoryofOralDiseases,NanjingMedicalUniversity,Nanjing,China3StateKeyLabofAnalyticalChemistryforLifeScience,NanjingUniversity,Nanjing,China4JiangsuKeyLaboratoryofMolecularMedicine,MedicalSchool,NanjingUniversity,Nanjing,ChinaSeverefeverwiththrombocytopeniasyndrome(SFTS)isanemerginghemorrhagicfeverwithahighmortalityrateinhumans,whichiscausedbySFTSvirus(SFTSV),anovelphlebovirusintheBunyaviridaefamily,istickborneandendemicinEasternAsia.PreviousstudyfoundthatSFTSVcaninfectandreplicateinmacrophagesinvivoandinvitro.However,theroleofmacrophagesinvirusreplicationandthepotentialpathogenicmechanismsofSFTSVinmacrophageremainunclear.Inthisstudy,weprovidedevidencethattheSFTSVinfectiondrovemacrophagedifferentiationskewedtoM2phenotype,facilitatedvirusshedding,andresultedinviralspread.WeshowedevidencethatmiR-146aandbweresignificantly