The disorder mainly affects males (68%). The median age of onset is 15 years (range, 4–82 years; 81% during the second decade), and the syndrome may last up ...

PDF | Objective: Kleine-Levin syndrome (KLS) is a rare disease of unknown etiology, the diagnosis of which can be challenging. We aimed to ...

KLS is very rare, occurring at a rate of 1 in 1 million, which limits research into genetic factors. The condition primarily affects adolescent ...

Kleine–Levin syndrome is a rare disorder with an estimated prevalence of 1 to 2 cases per million people. Patients are mostly adolescent boys; mean age of onset ...

The exact prevalence remains unknown. But it seems very rare: around one to two cases per million. All cases are not published. A review of the international ...

More than 500 cases have been reported in the medical literature. However, because cases of Kleine-Levin syndrome often go unrecognized, the ...

The disease predominantly affects adolescent males. Although no population-based studies reporting on KLS prevalence are available, it is generally considered ...

Epidemiology. It affects around 1/500 000 individuals. Patients are mostly male (68-78% of cases) and adolescents (81% of patients), with a mean age of onset of ...

We identified 7 patients with diagnosed KLS (6 since 2009), leading to a prevalence estimation of 3.19 per million (95% confidence interval: 1.55–6.59). Median ...