Kleine-Levin Syndrome Information Page | kleine-levin syndrome
SkiptomaincontentSubmitSearchCOVID-19Getthelatestfunding,research,andpublichealthinformationfromNINDSGetthelatestresearchinformationfromNIH|EspañolGetthelatestpublichealthinformationfromHHSGetthelatestpublichealthinformationfromCDCYouarehereHome»Disorders»AllDisordersKleine-LevinSyndromeInformationPageKleine-LevinSyndromeInformationPageWhatresearchisbeingdone?NINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisorders×Whatresearchisbeingdone?NINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisordersSeeMoreAboutResearchNINDSsupportsabroadrangeofclinicalandbasicresearchondiseasescausingsleepdisordersinanefforttoclarifythemechanismsoftheseconditionsandtodevelopbettertreatmentsforthem.InformationfromtheNationalLibraryofMedicine’sMedlinePlusSleepDisordersShowMoreShowLessSearchDisordersSEARCHDefinitionTreatmentPrognosisClinicalTrialsOrganizationsPublicationsDefinitionKleine-Levinsyndromeisararedisorderthatprimarilyaffectsadolescentmales(approximately70percentofthosewithKleine-Levinsyndromearemale).Itischaracterizedbyrecurringbutreversibleperiodsofexcessivesleep(upto20hoursperday).Symptomsoccuras"episodes,"typicallylastingafewdaystoafewweeks.Episodeonsetisoftenabrupt,andmaybeassociatedwithflu-likesymptoms.Excessivefoodintake,irritability,childishness,disorientation,hallucinations,andanabnormallyuninhibitedsexdrivemaybeobservedduringepisodes.Moodcanbedepressedasaconsequence,butnotacause,ofthedisorder.Affectedindividualsarecompletelynormalbetweenepisodes,althoughtheymaynotbeabletorememberafterwardseverythingthathappenedduringtheepisode.Itmaybeweeksormorebeforesymptomsreappear.Symptomsmayberelatedtomalfunctionofthehypothalamusa
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