Kleine–Levin syndrome | kleine-levin syndrome

Kleine–Levin syndrome (KLS) is a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also ...Kleine–LevinsyndromeFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchKleine–LevinsyndromeOthernamesFamilialhibernationsyndrome[1]SpecialtyNeurology Kleine–Levinsyndrome(KLS)isararedisordercharacterizedbypersistentepisodichypersomniaandcognitiveormoodchanges.Manypatientsalsoexperiencehyperphagia,hypersexualityandothersymptoms.Patientsgenerallyexperiencerecurrentepisodesoftheconditionformorethanadecadeandmayreturnatalaterage.Individualepisodesgenerallylastmorethanaweek,sometimeslastingformonths.Theconditiongreatlyaffectsthepersonal,professional,andsociallivesofsufferers.Theseverityofsymptomsandthecourseofthesyndromevarybetweensufferers.Patientscommonlyhaveabout20episodesoveraboutadecade.Severalmonthsgenerallyelapsebetweenepisodes.Theonsetoftheconditionusuallyfollowsaviralinfection;severaldifferentviruseshavebeenobservedtotriggerKLS.Itisgenerallyonlydiagnosedaftersimilarconditionshavebeenexcluded;MRI,CTscans,lumbarpuncture,andtoxicologytestsareusedtoruleoutotherpossibilities.Thesyndrome'smechanismisnotknown,butthethalamusisthoughttopossiblyplayarole.SPECThasshownthalamichypoperfusionofpatientsduringepisodes.KLSisveryrare,occurringatarateof1in1million,whichlimitsresearchintogeneticfactors.Theconditionprimarilyaffectsadolescentmales,thoughfemalescanalsobeaffectedandtheageofonsetvaries.Thereisnoknowncure,andthereislittleevidencesupportingdrugtreatment.Lithiumhasbeenreportedtohavelimitedeffectsincasereports,decreasingthelengthofepisodesanddurationbetweentheminsomepatients.[2]Stimulantshavebeenshowntopromotewakefulnessduringepisodes,buttheydonotcounteractcognitivesymptomsordecreasethedurationofepisodes.TheconditionisnamedafterWilliKleineandMaxLevin,[3]whodescribedcasesofthediseaseintheearly20thcentury.ItwasaddedtotheInternationalClassificationofSleepDisordersin1990.Contents1Symptoms2Cause3Diagnosis4Prevention5Treatm

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Kleine–Levin syndrome: a systematic review of 186 cases in ... | kleine-levin syndrome
Kleine–Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia and, to various degrees, behavioural or cognitive ...
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Kleine-Levin Syndrome (KLS) is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, ...
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Diagnosing Kleine-Levin Syndrome. Diagnosing KLS is admittedly a challenge but can be a relief for a family in search of answers. Because its primary ...
What is Kleine-Levin syndrome (KLS)? | kleine-levin syndrome
Kleine-Levin syndrome (KLS) is a rare disorder that starts during adolescence and has a male gender preference. The patients have recurrent episodes of ...
Kleine Levin syndrome | kleine-levin syndrome
Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterised by relapsing-remitting episodes of hypersomnia in association with ...
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Kleine-Levin syndrome (KLS) is a rare disorder that causes recurring periods of excessive sleepiness. In some cases, this means up to 20 hours a day are spent ...
Kleine-Levin Syndrome Information Page | kleine-levin syndrome
Kleine-Levin syndrome is a rare disorder that primarily affects adolescent males (approximately 70 percent of those with Kleine-Levin syndrome are male). It is ...
Kleine Levin syndrome | kleine-levin syndrome
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Kleine Levin syndrome.
Kleine–Levin syndrome | kleine-levin syndrome
Kleine–Levin syndrome (KLS) is a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also ...
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Kleine Levin syndrome | kleine-levin syndrome
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Kleine-Levin Syndrome Information Page | kleine-levin syndrome
Kleine-Levin Syndrome | kleine-levin syndrome