Kleine Levin syndrome | kleine-levin syndrome

Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterised by relapsing-remitting episodes of hypersomnia in association with ...xShareShareRarediseasesSearchClinicalSignsandSymptomsClassificationsGenesDisabilityEncyclopaediaforpatientsEncyclopaediaforprofessionalsEmergencyguidelinesSources/proceduresHomepageRarediseasesSearchSearchforararedisease*(*)mandatoryfieldSearchDiseasenameORPHAcodeOMIMICD-10GenenameorsymbolOthersearchoption(s)AlphabeticallistSuggestanupdate(*)Requiredfields.Youare(*)Choose:HealthprofessionalPatient/Family/AssociationBiopharmaceuticalindustryScientistStudentOtherIfyouhaveselectedtheOthercategory,pleasespecifywhichtypeofuseryouare:*Emailaddress:*Topicofyourcomment*EpidemiologydataSummaryandrelatedtextsRelatedgenesClinicalsignsNomenclatureand/orcodingYourmessage*(3000charactersremaining)AttentionOnlycommentsseekingtoimprovethequalityandaccuracyofinformationontheOrphanetwebsiteareaccepted.Forallothercomments,pleasesendyourremarksviacontactus.OnlycommentswritteninEnglishcanbeprocessed.CheckthisboxifyouwishtoreceiveacopyofyourmessagePleasereproducethetextbelow:*Kleine-LevinsyndromeDiseasedefinitionKleine-Levinsyndrome(KLS)isarareneurologicaldisorderofunknownorigincharacterisedbyrelapsing-remittingepisodesofhypersomniainassociationwithcognitiveandbehaviouraldisturbances.ORPHA:33543Classificationlevel:DisorderSynonym(s):-Prevalence:1-9/1000000Inheritance:-Ageofonset:Adolescent,Childhood,AdultICD-10:G47.8OMIM:148840UMLS:C0206085MeSH:D017593GARD:3117MedDRA:10053712SummaryEpidemiologyItaffectsaround1/500000individuals.Patientsaremostlymale(68-78%ofcases)andadolescents(81%ofpatients),withameanageofonsetof15years(range4-82years).ClinicaldescriptionThefirstepisodeistriggeredbyaninfectionin72%ofpatients.Patientsexperience7-19neurologicalepisodeswithadurationof10-13days/episodeandrelapsesevery3.5months.Onethirdofpatientshaveepisodeslastinglongerthanonemonth.Episodesrecurmorequicklyinpatientswithchildhoodonset.Duringepisod

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Kleine–Levin syndrome: a systematic review of 186 cases in ... | kleine-levin syndrome
Kleine–Levin syndrome (KLS) is a rare disease characterized by recurrent episodes of hypersomnia and, to various degrees, behavioural or cognitive ...
What is Kleine Levin Syndrome? | kleine-levin syndrome
Kleine-Levin Syndrome (KLS) is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, ...
Kleine-Levin Syndrome Diagnosis | kleine-levin syndrome
Diagnosing Kleine-Levin Syndrome. Diagnosing KLS is admittedly a challenge but can be a relief for a family in search of answers. Because its primary ...
What is Kleine-Levin syndrome (KLS)? | kleine-levin syndrome
Kleine-Levin syndrome (KLS) is a rare disorder that starts during adolescence and has a male gender preference. The patients have recurrent episodes of ...
Kleine Levin syndrome | kleine-levin syndrome
Kleine-Levin syndrome (KLS) is a rare neurological disorder of unknown origin characterised by relapsing-remitting episodes of hypersomnia in association with ...
Kleine-Levin Syndrome: Symptoms, Causes, and More | kleine-levin syndrome
Kleine-Levin syndrome (KLS) is a rare disorder that causes recurring periods of excessive sleepiness. In some cases, this means up to 20 hours a day are spent ...
Kleine-Levin Syndrome Information Page | kleine-levin syndrome
Kleine-Levin syndrome is a rare disorder that primarily affects adolescent males (approximately 70 percent of those with Kleine-Levin syndrome are male). It is ...
Kleine Levin syndrome | kleine-levin syndrome
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Kleine Levin syndrome.
Kleine–Levin syndrome | kleine-levin syndrome
Kleine–Levin syndrome (KLS) is a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also ...
Functional Magnetic Resonance Imaging in Narcolepsy and the ... | kleine-levin syndrome
Kleine Levin syndrome | kleine-levin syndrome
Kleine-Levin Syndrome: Symptoms, Causes, and More | kleine-levin syndrome
Kleine-Levin Syndrome Information Page | kleine-levin syndrome
Kleine-Levin Syndrome | kleine-levin syndrome