宮頸上皮內瘤樣病變（英語：Cervical intraepithelial neoplasia, CIN），也稱宮頸非典型增生（英語：cervical dysplasia）或宮頸間質瘤（cervical interstitial ...宮頸上皮內瘤樣病變維基百科，自由的百科全書跳至導覽跳至搜尋維基百科中的醫療相關內容僅供參考，詳見醫學聲明。

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宮頸上皮內瘤樣病變類型上皮瘤病變[*],dysplasiaofcervix[*]分類和外部資源醫學專科腫瘤學ICD-10D06,N87ICD-9-CM233.1,622.10MedlinePlus001491MeSHD018290[編輯此條目的維基數據]宮頸上皮內瘤樣病變（英語：Cervicalintraepithelialneoplasia,CIN），也稱宮頸非典型增生（英語：cervicaldysplasia）或宮頸間質瘤（cervicalinterstitialneoplasia），是宮頸不典型增生和宮頸鱗形細胞原位癌的總稱，也是宮頸浸潤癌的癌前期病變[1]。

宮頸上皮內瘤樣病變並非癌症，也能夠治療[2]。

絕大多數的宮頸上皮內瘤樣病變患者病情穩定，但是少量病例會惡化為宮頸癌[3]。

引起CIN的主要原因是人乳頭瘤病毒（HPV）在宮頸部位的慢性感染，特別是高感染度的16或18型HPV。

在顯微鏡下看到的最早病理是子宮頸的上皮細胞或表面發育不良，並且在婦女體內無法本質上發現。

在HPV感染後能夠看到細胞改變，比如挖空細胞（英語：koilocyte）中通常能夠看到宮頸上皮內瘤樣病變。

宮頸上皮內瘤樣病變通常通過篩選試驗發現，比如通過巴氏塗片法（英語：BethesdaSystem）進行子宮頸抹片檢查，檢測可能的癌前症狀。

檢查若不正常，則需要子宮陰道鏡進行放大，或進行活體檢查。

目錄1病因2分類3治療4預後5流行病學6相關條目7參考文獻病因[編輯]宮頸上皮內瘤樣病變的病因比較複雜，與此疾病有明顯相關性的因素有[1]：感染「高危」型人乳頭瘤病毒（比如第16、18、31、45型）的婦女患有免疫力缺陷的婦女17歲之前生孩子的婦女此外一些危險因素會引起宮頸上皮內瘤樣病變[4]，包括節食、多名性伴侶、缺乏保險套使用、以及吸菸。

分類[編輯]根據患有HPV的不同類型和感染部位，宮頸上皮內瘤樣病變可以分為三個級別，病情可能會加重或復原[1]。

宮頸上皮內瘤樣病變分為以下幾級：組織學分級細胞學描述圖像––正常宮頸鱗狀上皮CIN1（I級，輕度不典型增生）低度鱗狀上皮內病變（英語：lowgradesquamousintraepitheliallesion）[5]最低危險的類型，表現為輕度的發育異常，也是不正常的細胞增殖[3]。

局限於宮頸上皮層的下1/3，病變部分與正常細胞層分界清楚。

如果病情與HPV感染有關，通過一年左右的免疫反應疾病會康復，一切病情需要更長恢復時間。

CIN2/3高度鱗狀上皮內病變（英語：highgradesquamousintraepitheliallesion）CIN2型和CIN3型的前期症狀CIN2（II級）不典型增生細胞占宮頸上皮層的下部2/3，病變部分與正常細胞層分界清楚。

CIN3（III級）不典型增生細胞幾乎浸及全上皮層，僅剩表面正常鱗狀上皮細胞。

病情可能會判定為子宮頸原位癌。

治療[編輯]對於CIN1型的患者，可通過時間自愈而選擇暫緩治療[6]。

然而對這些患者應定期密切隨診，定期行宮頸脫落細胞學及陰道鏡檢查。

如果在12個月內，經過多次檢查病變仍持續存在或進展，就應該開始治療[6]。

對多數中度不典型增生、所有重度不典型增生及原位癌的患者，均應給予積極的治療，其中包括冷灼法（英語：cryocautery）、電烙術（英語：electrocautery）、燒烙術（英語：Cauterization）、行子宮頸電熱圈環切術（英語：loopelectricalexcisionprocedure）或宮頸錐切術（英語：cervicalconization）。

有治療意義的HPV疫苗正在臨床試驗階段。

宮頸上皮內瘤樣病變的手術治療可能會導致女性不育症（英語：femaleinfertility）或生育能力降低的危險增加[7]。

預後[編輯]通常認為宮頸上皮內瘤樣病變均隨著階段惡化形成癌症的情況是呈線性關係[3][8

There is evidence indicating that 90% of HPV (Human Papilloma Virus) patients with cervical cancer are associated with early age sexual activities and poor ...HygieneEducationHealthEducationHomeHygieneEducationCervicalIntraepithelialNeoplasia子宮頸上皮內贅瘤(英文)HygieneEducationHealthEducationCervicalIntraepithelialNeoplasia子宮頸上皮內贅瘤(英文)文章分享Home分享至FaceBook分享至LineQrcode列印下載A-A+CervicalIntraepithelialNeoplasia子宮頸上皮內贅瘤(英文)2021/1/12IntroductionCervicalcancerisoneofthemostcommonmalignanttumorforTaiwanesewomen;andclinicallyitisdiscriminatedintoprecancerouslesion(cervicalintraepithelialneoplasia)andinvasivecancer.Researchesalsoindicatethatmostinvasivecervicalcancersresultfromprecancerouslesionsandtherearedifferentdegreestocervicalintraepithelialneoplasiaandcarcinomainsitu.EtiologyThereisevidenceindicatingthat90%ofHPV(HumanPapillomaVirus)patientswithcervicalcancerareassociatedwithearlyagesexualactivitiesandpoorhygiene.ThreedegreesofCINCINI(mild):Withmilddysplasia,abnormaltissuesofteninvade1/3ofepithelium.CINII(moderate):Moderatedysplasiatakesup2/3oftheepithelium;cellsarewell-differentiatedbuttheconditionispoorerthanCINI.CINIII(severe):Severedysplasiawithepitheliumoftenreachesalmosttheentiresurface.ClinicalpresentationEarlystage:TherearenospecificsymptomsandmostlycervicalcancerisdetectedbyPapsmear.Latestage:Thereisincreaseofvaginaldischargeandabnormalbleedingorpost-coitalbleeding.TreatmentTherearechancesforCINIpatientstocompletelyrecover,sofurthertreatmentisunnecessary;butevery3-6monthsPapsmeartestisrequired.CINIIcanbetreatedlocallyandtreatmentmeansincludeslasersurgery,LEEP(LoopElectricExcisionProcedure),andtherapeuticconizationofcervix.PatientswithCINIIIcanbetreatedwithcervicalconization;butpatientswithinvasivecancerandothercomplications,completehysterectomyisrequired.PlansafterbeingdischargedfromthehospitalReturntothehospitalifanyofthefollowingconditionsoccurs:MassivevaginalbleedingFeverupto38℃SeverelowerabdominalpainItnormallytakes3-4weeksforthewoundtorecover,sopatientsshouldrestmo

Cervical intraepithelial neoplasia (CIN) is a premalignant condition of the uterine cervix. The ectocervix (surface of the cervix that is visualized ...

INTRODUCTION — Cervical intraepithelial neoplasia (CIN) is a premalignant squamous lesion of the uterine cervix diagnosed by cervical ...

CIN-1 (low-grade) involves the lower 1/3 or less of the epithelium, whereas the more significant CIN-2 and CIN-3 (high-grade) progress to include ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermCervicalIntraepithelialNeoplasiaVickieMello;ReneeK.Sundstrom.AuthorInformationAuthorsVickieMello1;ReneeK.Sundstrom2.Affiliations1CentralMichiganUniversityCovenantMC2CentralMichiganUniversityLastUpdate:August12,2020.ContinuingEducationActivityCervicalcancerincidenceandmortalityhavedecreaseddueprimarilytoscreeningprogramsusingthepapsmear.Asmoreoutcomedatahasbecomeavailable,screeningandtreatmentguidelinesforcervicalintraepithelialneoplasia(CIN)haveevolved.Detectionofthediseaseinaprecancerousstate,closemonitoring,andtreatmentareparamountinthepreventionofcervicalcancer.Thescreeningprocessforcervicalcancerinvolvespapsmearcytologyofthecervixalongwithhumanpapillomavirus(HPV)testingincertaincircumstances.Thisactivityreviewstheevaluation,treatment,andcomplicationsofcervicalintraepithelialneoplasiaandunderscorestheimportanceofaninterprofessionalteamapproachtoitsmanagement.Objectives:Describetheepidemiologicaltrendsforcervicalintraepithelialneoplasia.Reviewthemostcommonssymptomsassociatedwithcervicalintraepithelialneoplasia.Summarizethetreatmentoptionsforcervicalintraepithelialneoplasia.Explaintheimportanceofinterprofessionalteamstrategiesforimprovingcarecoordinationandcommunicationtoaidinpromptdiagnosisofcervicalintraepithelialneoplasiaandimprovingoutcomesinpatientsdiagnosedwiththecondition.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionCervicalcancerincidenceandmortalityhavedecreaseddueprimarilytoscreeningprogramsusingthepapsmear.Asmoreoutcomedatahasbecomeavailable,screening,andtreatme

Cervical intraepithelial neoplasia (CIN) is a precancerous condition in which abnormal cells grow on the surface of the cervix. The cervix is the ...NowschedulingCOVID-19vaccineappointmentsforages16+LearnhowtoscheduleCOVID-19vaccineFAQsNewvisitationhoursNeedaCOVID-19testbeforetravel,schoolorchildcare?Home/HealthLibrary/Disease&ConditionsCervicalIntraepithelialNeoplasia(CIN)Cervicalintraepithelialneoplasia(CIN)isaprecancerousconditioninwhichabnormalcellsgrowonthesurfaceofthecervix.Appointments216.444.6601Appointments&LocationsHaveMyBabyatClevelandClinicOverviewSymptomsandCausesDiagnosisandTestsManagementandTreatmentPreventionCervicalIntraepithelialNeoplasia(CIN)OverviewSymptomsandCausesDiagnosisandTestsManagementandTreatmentPreventionBackToTopOverviewWhatiscervicalintraepithelialneoplasia(CIN)?Cervicalintraepithelialneoplasia(CIN)isaprecancerousconditioninwhichabnormalcellsgrowonthesurfaceofthecervix.Thecervixistheopeningbetweenthevaginaandtheuterusinwomen.“Intraepithelial”meansthattheabnormalcellsarepresentonthesurface(epithelialtissue)ofthecervix.Theword“neoplasia”referstothegrowthofnewcells.AnothernameforCINiscervicaldysplasia.ItisimportanttorememberthatmostpeoplewithCINdonotgetcancer.Ifcancerdoesform,ittakesyearstodevelop,givingdoctorstimetofindandremoveproblemareas.WhataretheclassificationsofCIN?Cervicalintraepithelialneoplasiamaybeclassifiedaccordingtohowmuchepithelialtissueisaffected:Low-gradeneoplasia(CIN1)referstodysplasiathatinvolvesaboutone-thirdofthethicknessoftheepithelium.CIN2referstoabnormalchangesinaboutone-thirdtotwo-thirdsoftheepitheliallayer.CIN3(themostsevereform)describesaconditionthataffectsmorethantwo-thirdsoftheepithelium.HowcommonisCIN?About250,000to1millionwomenintheU.SarediagnosedwithCINeachyear.Theconditionisfoundmoreoftenamongwomenofchildbearingage,particularlyamongwomenaged25to35.SymptomsandCausesWhatarethesymptomsofcervicalintraepithelialneoplasia(CIN)?CINdoesnotusuallycauseanysymptoms.AbnormalcellsarefoundonlyafteraroutinePapsmear.What

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer. More specifically, CIN refers to the potentially precancerous transformation of cells of the cervix.CervicalintraepithelialneoplasiaFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchMedicalconditionCervicalintraepithelialneoplasiaOthernamesCervicaldysplasiaPositivevisualinspectionwithaceticacidofthecervixforCIN-1SpecialtyGynecologyCervicalintraepithelialneoplasia(CIN),alsoknownascervicaldysplasia,istheabnormalgrowthofcellsonthesurfaceofthecervixthatcouldpotentiallyleadtocervicalcancer.[1]Morespecifically,CINreferstothepotentiallyprecanceroustransformationofcellsofthecervix.CINmostcommonlyoccursatthesquamocolumnarjunctionofthecervix,atransitionalareabetweenthesquamousepitheliumofthevaginaandthecolumnarepitheliumoftheendocervix.[2]Itcanalsooccurinvaginalwallsandvulvarepithelium.CINisgradedona1-3scale,with3beingthemostabnormal(seeclassificationsectionbelow).Humanpapillomavirus(HPV)infectionisnecessaryforthedevelopmentofCIN,butnotallwiththisinfectiondevelopcervicalcancer.[3]ManywomenwithHPVinfectionneverdevelopCINorcervicalcancer.Typically,HPVresolvesonitsown.[4]However,thosewithanHPVinfectionthatlastsmorethanoneortwoyearshaveahigherriskofdevelopingahighergradeofCIN.[5]Likeotherintraepithelialneoplasias,CINisnotcancerandisusuallycurable.[3]MostcasesofCINeitherremainstableorareeliminatedbytheperson'simmunesystemwithoutneedforintervention.However,asmallpercentageofcasesprogresstocervicalcancer,typicallycervicalsquamouscellcarcinoma(SCC),ifleftuntreated.[6]Contents1Signsandsymptoms2Causes3Pathophysiology4Diagnosis4.1Classification4.2ChangesinTerminology5Screening5.1Primaryprevention5.2Secondaryprevention6Treatment7Outcomes8Epidemiology9References10ExternallinksSignsandsymptoms[edit]Seealso:Cervicalcancer§ SignsandsymptomsTherearenospecificsymptomsofCINalone.Generally,signsandsympt

Abnormal cells are found on the surface of the cervix. Cervical intraepithelial neoplasia is usually caused by certain types of human papillomavirus (HPV) and is ...SkiptomaincontentEspañol1-800-4-CANCERLiveChatPublicationsDictionaryHomePublicationsNCIDictionariesPublicationsPatientEducationPublicationsPDQ®CancerInformationSummariesAdultTreatmentPediatricTreatmentSupportive&PalliativeCareCancerScreeningCancerPreventionCancerGeneticsIntegrativeTherapiesEditorialBoardsAdultTreatmentEditorialBoardPediatricTreatmentEditorialBoardSupportive&PalliativeCareEditorialBoardScreening&PreventionEditorialBoardCancerGeneticsEditorialBoardIntegrativeTherapiesEditorialBoardLevelsofEvidenceLevelsofEvidence:TreatmentLevelsofEvidence:Supportive&PalliativeCareLevelsofEvidence:Screening&PreventionLevelsofEvidence:CancerGeneticsLevelsofEvidence:IntegrativeTherapiesFactSheetsNCIDictionariesDictionaryofCancerTermsDrugDictionaryDictionaryofGeneticsTermsBlogsandNewslettersHealthCommunicationsPublicationsReports