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1. Hydatidiform mole: Recognition and management
Hydatidiform mole is an abnormal pregnancy characterized by varying degrees of trophoblastic proliferation (both cytotrophoblast and ...SpotlightNoninvasivePrenatalTestingAddressingtheCervicalCancerScreeningDisparitiesGapAdvancesintheTestingforPretermPrematureRuptureofMembraneBetterForWomenSeriesCervicalCancer&Co-TestingCervicalCancerScreening:ProtectingandImprovingHealthOutcomesofWomenCervicalCancerTodayCombinationRegimenofEstradiolandProgesteroneEndometriosisEnhancedRecoveryforCesareanDeliveriesintheUnitedStates:PerspectivesFromtheFrontLines–Part1LARCProviderToolkitLong-Lasting,ReversibleContraceptionManagementofUterineFibroidsMenopauseUterineFibroidClinicalSeeAll>ContraceptionCOVID-19GynecologyLegallySpeakingLifeTransitionsObstetricsVulvovaginalWellWomanAdvertiseContactUsJobBoardEditorialTermsofUsePrivacyPolicyDoNotSellMyPersonalInformation©2021MJHLifeSciences™andContemporaryOB/GYN.Allrightsreserved.Hydatidiformmole:RecognitionandmanagementMarch13,2019JohnR.Lurain,MDJohnR.Lurain,MDContemporaryOB/GYNJournal,Vol.64No03,Volume64,Issue03Molarpregnanciesmaybeassociatedwithseriousmorbiditysopromptdiagnosis,appropriatemanagement,andfollow-upareessential.Hydatidiformmoleisanabnormalpregnancycharacterizedbyvaryingdegreesoftrophoblasticproliferation(bothcytotrophoblastandsyncytiotrophoblast)andvesicularswellingofplacentalvilliassociatedwithanabsentorabnormalfetus/embryo.Twotypesofhydatidiformmole,completeandpartial,havebeendescribedbasedonbothmorphologicandcytogeneticcriteria(Table1).1,2 EpidemiologyEpidemiologicstudieshavereportedwideregionalvariationsintheincidenceofmolarpregnancies.EstimatesfromstudiesinNorthAmerica,Europe,AustraliaandNewZealandhaveshownincidenceratesrangingfrom0.57-1.1per1000pregnancies,whereasstudiesinSoutheastAsiaandJapanhavesuggestedanincidencerateashighas2.0per1000pregnancies.Thesereporteddifferencesmayberelatedtolackofstandardizationofdatacollectionandreportingratherthantrueincidencedifferences.However,socioeconomicstatusanddietratherthangeneticor
2. Hydatidiform Mole
A hydatiform mole (also known as a molar pregnancy) is a gestational trophoblastic disease (GTD), which originates from the placenta and can ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermHydatidiformMoleSassanGhassemzadeh;MichaelKang.AuthorInformationAuthorsSassanGhassemzadeh1;MichaelKang2.Affiliations1RiversideCommHosp,UCRiverside2UniversityofCaliforniaRiversideSchoolofMedicineLastUpdate:January16,2021.ContinuingEducationActivityAhydatiformmole(alsoknownasamolarpregnancy)isagestationaltrophoblasticdisease(GTD),whichoriginatesfromtheplacentaandcanmetastasize.Itisuniqueinthatthetumororiginatesfromgestationaltissueratherthanfrommaternaltissue.Hydatiformmoles(HM)arecategorizedascompleteandpartialandareusuallyconsideredthenoninvasiveformofgestationaltrophoblasticdisease.Whilehydatiformmolesaretypicallydeemedbenign,theyarepremalignantanddohavethepotentialtobecomemalignantandinvasive.Thisactivitydescribesthepathophysiology,evaluation,andmanagementofhydatiformmolesandhighlightstheroleoftheinterprofessionalteaminthemanagementofaffectedpatients.Objectives:Identifytheetiologyofahydatiformmole.Describethepresentationofapatientwithahydatiformmole.Reviewthetreatmentandmanagementoptionsavailableforhydatiformmoles.Explaininterprofessionalteamstrategiesforimprovingcarecoordinationandcommunicationtoadvancethetreatmentofhydatiformmolesandimproveoutcomes.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionHydatiformmole(alsoknownasmolarpregnancy)isasubcategoryofdiseasesundergestationaltrophoblasticdisease(GTD),whichoriginatesfromtheplacentaandcanmetastasize.Itisuniquebecausethetumororiginatesfromgestationaltissueratherthanfrommaternaltissue.Otherformsof gestationaltrophoblasticdisease in
3. Hydatidiform mole: Treatment and follow-up
Hydatidiform mole (HM) is one of a group of diseases that develop from abnormal proliferation of trophoblast and are classified as gestational ...
4. Molar pregnancy
A molar pregnancy — also known as hydatidiform mole — is a rare complication of pregnancy characterized by the abnormal growth of ...Scheduleyourappointmentnowforsafein-personcare.Learnmore:MayoClinicfactsaboutcoronavirusdisease2019(COVID-19)Our COVID-19patient andvisitorguidelines,plustrustedhealthinformationLateston COVID-19vaccination bysite:ArizonapatientvaccinationupdatesArizona,FloridapatientvaccinationupdatesFlorida,RochesterpatientvaccinationupdatesRochesterandMayoClinicHealthSystempatientvaccinationupdatesMCHSSkiptositenavigationSkiptoContentThiscontentdoesnothaveanEnglishversion.ThiscontentdoesnothaveanArabicversion.SectionsforMolarpregnancySymptoms&causesDiagnosis&treatmentPrintOverviewAmolarpregnancy—alsoknownashydatidiformmole—isararecomplicationofpregnancycharacterizedbytheabnormalgrowthoftrophoblasts,thecellsthatnormallydevelopintotheplacenta.Therearetwotypesofmolarpregnancy,completemolarpregnancyandpartialmolarpregnancy.Inacompletemolarpregnancy,theplacentaltissueisabnormalandswollenandappearstoformfluid-filledcysts.There'salsonoformationoffetaltissue.Inapartialmolarpregnancy,theremaybenormalplacentaltissuealongwithabnormallyformingplacentaltissue.Theremayalsobeformationofafetus,butthefetusisnotabletosurvive,andisusuallymiscarriedearlyinthepregnancy.Amolarpregnancycanhaveseriouscomplications—includingarareformofcancer—andrequiresearlytreatment.Products&ServicesBook:MayoClinicGuidetoaHealthyPregnancySymptomsMolarpregnancyOpenpop-updialogboxCloseMolarpregnancyMolarpregnancyDuringamolarpregnancy,theplacentadevelopsintoanabnormalmassofcysts.Theembryoeitherdoesn'tformorismalformedandcan'tsurvive.Amolarpregnancymayseemlikeanormalpregnancyatfirst,butmostmolarpregnanciescausespecificsignsandsymptoms,including:DarkbrowntobrightredvaginalbleedingduringthefirsttrimesterSeverenauseaandvomitingSometimesvaginalpassageofgrapelikecystsPelvicpressureorpainIfyouexperienceanysignsorsymptomsofamolarpregnancy,consultyourdoctororpregnancycareprovider.Heorshemaydetectother
5. Complete hydatidiform mole
A complete hydatidiform mole (CHM) is a type of molar pregnancy and falls at the benign end of the spectrum of gestational trophoblastic disease. Epidemiology ...×ArticlesLogInCasesSignUpCoursesQuizBlogDonateAbout×MenuSearchADVERTISEMENT:Radiopaediaisfreethankstooursupportersandadvertisers.BecomeaGoldSupporterandseenoads.ArticlesCasesCoursesLogInLoginSignup{"url":"/signup-modal-props.json?lang=us\u0026email="}ArticlesCasesCoursesQuizAboutBlogGoad-freeSearchCompletehydatidiformmoleDrMohamedSaberandRadswiki◉etal.Acompletehydatidiformmole(CHM)isatypeofmolarpregnancyandfallsatthebenignendofthespectrumofgestationaltrophoblasticdisease. Onthispage:Article:EpidemiologyPathologyRadiographicfeaturesTreatmentandprognosisSeealsoRelatedarticlesReferencesImages:CasesandfiguresImagingdifferentialdiagnosisEpidemiologyAcompletehydatidiformmoleisthecommonesttypeofgestationaltrophoblasticdisease.PathologyCompletemolesarecharacterizedbytheabsenceofafetusorfetalparts(i.e.noembryonictissues).Thereisanon-invasive,diffuseswellingofchorionicvilli.ChromosomalcompositionApproximately90%ofcompletehydatidiformmoleshavea46XXdiploidchromosomalpatternwith~10%havinga46XYcomposition.Allthechromosomesarederivedfromthesperm,suggestingfertilisationofasingleeggthathaslostitschromosomes.MarkersSerumbetaHCGlevelsaremarkedlyelevated,outofproportiontothepregnancy. RadiographicfeaturesUltrasoundenlargeduterusmaybeseenasanintrauterinemasswithcysticspaceswithoutanyassociatedfetalpartsthemultiplecysticstructuresclassicallygivea"snowstorm"or"bunchofgrapes"typeappearance.maybedifficulttodiagnoseinthefirsttrimester6mayappearsimilartoanormalpregnancyorasanemptygestationalsac<50%arediagnosedinthefirsttrimesterbilateralthecaluteincystsmayalsobeseenonultrasoundcolorDopplerinterrogationmayshowhighvelocitywithalowimpedanceflowCTCTevaluationisnotusuallyperformedduetoitslowresolutionfortheuterineassessment. CTmayshowanenlargeduteruswithareasoflowattenuation,orhypoattenuatingfocisurroundedbyhighlyenhancedareasinthemyometr
6. Complete hydatidiform mole
Cite this page · A complete mole occurs when an empty ovum is fertilized by a sperm · About 80% of complete hydatidiform moles are 46XX, which ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsClickHeretoseeourTop25Authorsandallauthorsin2020.JobsFellowshipsConferences/WebinarsBooksOnlineCMECasesAdvertiseIndustryNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Placenta>CompletehydatidiformmolePlacentaGestationaltrophoblasticdiseaseMolarpregnanciesCompletehydatidiformmoleAuthors: RachelleMendoza,M.D.,SonaliLanjewar,M.B.B.S.,RaaviGupta,M.D.EditorialBoardMember: RicardoR.Lastra,M.D.DeputyEditor-in-Chief: JenniferA.Bennett,M.D.TopicCompleted:22February2021Minorchanges:22February2021Copyright:2002-2021,PathologyOutlines.com,Inc.PubMedsearch:Completehydatidiformmole[title]placentaPageviewsin2020:35,455Pageviewsin2021todate:10,894TableofContentsDefinition/general|Essentialfeatures|Terminology|ICDcoding|Epidemiology|Sites|Pathophysiology|Etiology|Diagrams/tables|Clinicalfeatures|Diagnosis|Laboratory|Radiologydescription|Radiologyimages|Prognosticfactors|Casereports|Treatment|Grossdescription|Grossimages|Microscopic(histologic)description|Microscopic(histologic)images|Positivestains|Negativestains|Molecular/cytogeneticsdescription|Molecular/cytogeneticsimages|Videos|Samplepathologyreport|Differentialdiagnosis|Additionalreferences|Boardreviewstylequestion#1|Boardreviewstyleanswer#1|Boardreviewstylequestion#2|Boardreviewstyleanswer#2Citethispage:MendozaR,LanjewarS,GuptaR.Completehydatidiformmole.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/placentacompletemole.html.AccessedMarch27th,2021.Definition/generalCompletehydatidiformmoleisagestationaltrophoblasticdiseasecharacterizedbydiffusehydropicenlargementandtrophoblasticproliferationofthechorionicvilliEssentialfeaturesProliferativedisorderoftheplacenta,resultinginvilloushydropsandtrophoblastichyperplasiawithoutembry