Hodgkin lymphoma (HL) is a type of lymphoma, in which cancer originates from a specific type of white blood cells called lymphocytes, where multinucleated ...HodgkinlymphomaFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchTypeofbloodandimmune-systemcancerMedicalconditionHodgkinlymphomaOthernamesHodgkin'slymphoma,Hodgkin'sdisease[1]MicrographshowingHodgkinlymphoma(Fieldstain)SpecialtyHematologyandoncologySymptomsFever,nightsweats,weightloss,non-painfulenlargelymphnodes[2]RiskfactorsEpstein–Barrvirus,familyhistory,HIV/AIDS[2][3]DiagnosticmethodLymphnodebiopsy[2]TreatmentChemotherapy,radiationtherapy,stemcelltransplant,[4]immunotherapyPrognosisFive-yearsurvivalrate86%(USA)[5]Frequency574,000(affectedduring2015)[6]Deaths23,900(2015)[7]Hodgkinlymphoma(HL)isatypeoflymphoma,inwhichcanceroriginatesfromaspecifictypeofwhitebloodcellscalledlymphocytes,wheremultinucleatedReed–Sternbergcells(RScells)arepresentinthepatient'slymphnodes.[2][8]Symptomsmayincludefever,nightsweats,andweightloss.[2]Oftentherewillbenon-painfulenlargedlymphnodesintheneck,underthearm,orinthegroin.[2]Thoseaffectedmayfeeltiredorbeitchy.[2]TherearetwomajortypesofHodgkinlymphoma:classicHodgkinlymphomaandnodularlymphocyte-predominantHodgkinlymphoma.[5]AbouthalfofcasesofHodgkinlymphomaareduetoEpstein–Barrvirus(EBV)andthesearegenerallytheclassicform.[3][9]OtherriskfactorsincludeafamilyhistoryoftheconditionandhavingHIV/AIDS.[2][3]DiagnosisisconductedbyconfirmingthepresenceofcancerandidentifyingRScellsinlymphnodebiopsies.[2]Thevirus-positivecasesareclassifiedasaformoftheEpstein-Barrvirus-associatedlymphoproliferativediseases.[10]Hodgkinlymphomamaybetreatedwithchemotherapy,radiationtherapy,andstemcelltransplant.[4]Thechoiceoftreatmentoftendependsonhowadvancedthecancerhasbecomeandwhetherornotithasfavorablefeatures.[4]Inearlydisease,acureisoftenpossible.[11]IntheUnitedStates,86%ofpeoplediagnosedwithHodgkinLymphomasurvivefor5yearsorlonger.[5]Forthoseundertheageof20,ratesofsurvivalare97%.[12]Radiationandsom

Hodgkin lymphoma is caused by a change (mutation) in the DNA of a type of white blood cell called B lymphocytes, although the exact reason why this happens ...SkiptomaincontentHomeHealthAtoZHodgkinlymphomaBacktoHodgkinlymphomaCauses-HodgkinlymphomaContentsOverviewSymptomsCausesDiagnosisTreatmentComplicationsHodgkinlymphomaiscausedbyachange(mutation)intheDNAofatypeofwhitebloodcellcalled Blymphocytes,althoughtheexactreasonwhythishappensisn'tknown.TheDNAgivesthecellsabasicsetofinstructions,suchaswhentogrowandreproduce.ThemutationintheDNAchangestheseinstructionssothecellskeepgrowing,causingthemtomultiplyuncontrollably.Theabnormallymphocytesusuallybegintomultiplyinoneormorelymphnodesinaparticularareaofthebody,suchasyourneckorgroin.Overtime,it'spossiblefortheabnormallymphocytestospreadintootherpartsofyourbody,suchasyour:bonemarrowspleenliverskinlungsWho'smostatrisk?Whilethe causeoftheinitialmutationthattriggersHodgkinlymphomaisunknown,anumberoffactorscanincreaseyourriskofdevelopingthecondition.Theseinclude:havingamedicalconditionthatweakensyourimmunesystem,suchasHIVhavingmedicaltreatmentthatweakensyourimmunesystem–forexample,takingmedicationtosuppressyourimmunesystemafteranorgantransplantbeingpreviouslyexposedtotheEpstein-Barrvirus(EBV)– acommonvirusthatcausesglandularfeverhavingpreviouslyhad non-Hodgkinlymphoma,possiblybecauseoftreatmentwith chemotherapy orradiotherapybeingveryoverweight(obese) – thismaybemoreofariskfactorinwomenthanmenHodgkinlymphomaisn'tinfectiousand isn'tthoughtto runinfamilies.Althoughyour riskis increasedifafirst-degreerelative(parent,siblingorchild)hashadlymphoma,it'snotclearifthisisbecauseofaninheritedgeneticfault or lifestylefactors.Hodgkinlymphomacanoccuratanyage,althoughmostcasesarediagnosedinpeopleintheirearly20sor70s.Theconditionisslightlymorecommoninmenthanwomen.Pagelastreviewed:20September2018Nextreviewdue:20September2021Previous:SymptomsNext:Diagnosis

Hodgkin's disease (HD) is a type of lymphoma, which is a blood cancer that starts in the lymphatic system. The lymphatic system helps the immune system get ...Hodgkin’sDiseaseMedicallyreviewedbyYaminiRanchod,Ph.D.,M.S.—WrittenbyJaimeHerndon,MS,MPH,MFA—UpdatedonSeptember17,2018SymptomsDiagnosisTreatmentRisksOutlookWhatisHodgkin’sdisease?Hodgkin’sdisease(HD)isatypeoflymphoma,whichisabloodcancerthatstartsinthelymphaticsystem.Thelymphaticsystemhelpstheimmunesystemgetridofwasteandfightinfections.HDisalsocalledHodgkindisease,Hodgkinlymphoma,andHodgkin’slymphoma.HDoriginatesinwhitebloodcellsthathelpprotectyoufromgermsandinfections.Thesewhitebloodcellsarecalledlymphocytes.InpeoplewithHD,thesecellsgrowabnormallyandspreadbeyondthelymphaticsystem.Asthediseaseprogresses,itmakesitmoredifficultforyourbodytofightinfections.HDcanbeeitherclassicHodgkin’sdiseaseornodularlymphocyticpredominantHodgkin’slymphoma(NLPHL).ThetypeofHDisbasedonthetypesofcellsinvolvedinyourconditionandtheirbehavior.ThemaincauseofHDisn’tknown.ThediseasehasbeenlinkedtoDNAmutations,orchanges,aswellastotheEpstein-Barrvirus(EBV),whichcausesmononucleosis.HDcanoccuratanyage,butitmostcommonlyaffectspeoplebetweenages15and40andpeopleoverage55.WhatarethesymptomsofHodgkin’sdisease?ThemostcommonsymptomofHDisswellingofthelymphnodes,whichcausesalumptoformundertheskin.Thislumpusuallyisn’tpainful.Itmayforminoneormoreofthefollowingareas:onthesideoftheneckinthearmpitaroundthegroinOthersymptomsofHDinclude:nightsweatsitchyskinfeverfatigueunintendedweightlosspersistentcough,troublebreathing,chestpainpaininthelymphnodesafterconsumingalcoholenlargedspleenCallyourdoctorrightawayifyouhaveanyofthesesymptoms.Theycanbesignsofotherconditions,andit’simportanttogetanaccuratediagnosis.HowisHodgkin’sdiseasediagnosed?TodiagnoseHD,yourdoctorwillperformaphysicalexamandaskyouaboutyourmedicalhistory.Yourdoctorwillalsoordercertaintestssotheycanmakeaproperdiagnosis.Thefollowingtestsmaybedone:imagingtests,suchasX-raysorCTscanslymphnodebiopsy,whichinv