Background: Lymphoepithelioma-like carcinoma (LELC) is a rare malignant tumor of the lung. It is related to EB virus infection.JournalsWhyPublishWithUs?EditorialPoliciesAuthorGuidelinesPeerReviewGuidelinesOpenOutlookCOVID-19BlogReprintsSubmitNewManuscriptMenuAboutContactSustainabilityAwardsPressCenterTestimonialsBlogFavoredAuthorProgramPermissionsPre-SubmissionReprintsLoginopenaccesstoscientificandmedicalresearchAdvancedsearchHomeJournalsWhypublishwithus?EditorialPoliciesAuthorInformationPeerReviewGuidelinesOpenOutlookCOVID-19AverageArticleStatistics21Days*Fromsubmissiontofirsteditorialdecision.13Days*Fromeditorialacceptancetopublication.*Businessdays(Mon-Fri)RejectionRate81%Theabovepercentageofmanuscriptshavebeenrejectedinthelast12months.67217PapersPublishedSubmitNewManuscriptLogintoviewexistingmanuscriptstatusSignupforJournalalertsAboutDovePressOpenaccesspeer-reviewedscientificandmedicaljournals.LearnmoreOpenAccessDoveMedicalPressisamemberoftheOAI.LearnmoreReprintsBulkreprintsforthepharmaceuticalindustry.LearnmoreFavoredAuthorsWeofferrealbenefitstoourauthors,includingfast-trackprocessingofpapers.LearnmorePromotionalArticleMonitoringRegisteryourspecificdetailsandspecificdrugsofinterestandwewillmatchtheinformationyouprovidetoarticlesfromourextensivedatabaseandemailPDFcopiestoyoupromptly.LearnmoreSocialMedia   BacktoJournals»OncoTargetsandTherapy»Volume14OriginalResearchPulmonaryLymphoepithelioma-LikeCarcinomaTreatedwithImmunotherapyorChemotherapy:ASingleInstituteExperience            FulltextMetricsGetPermissionCitethisarticleAuthorsFuY,ZhengY,WangPP,ChenYY,DingZYReceived12November2020Acceptedforpublication18January2021Published16February2021Volume2021:14Pages1073—1081DOIhttps://doi.org/10.2147/OTT.S290113CheckedforplagiarismYesReviewbySingleanonymouspeerreviewPeerreviewercomments2Editorwhoapprovedpublication:Prof.Dr.NicolaSilvestrisDownloadArticle[PDF] YangFu,*YueZheng,*Pei-PeiWang,Yue-YunChen,Zhen-YuDingDepartmentofBiotherapy,CancerCenter,WestChinaHospital,WestChi

The radiographic, CT, and MRI features of primary pulmonary LELC are nonspecific, often resembling those of bronchogenic carcinoma. Primary pulmonary LELC ...AnErrorOccurredSettingYourUserCookieThissiteusescookiestoimproveperformance.Ifyourbrowserdoesnotacceptcookies,youcannotviewthissite.SettingYourBrowsertoAcceptCookiesTherearemanyreasonswhyacookiecouldnotbesetcorrectly.Belowarethemostcommonreasons:Youhavecookiesdisabledinyourbrowser.Youneedtoresetyourbrowsertoacceptcookiesortoaskyouifyouwanttoacceptcookies.Yourbrowserasksyouwhetheryouwanttoacceptcookiesandyoudeclined.Toacceptcookiesfromthissite,usetheBackbuttonandacceptthecookie.Yourbrowserdoesnotsupportcookies.Tryadifferentbrowserifyoususpectthis.Thedateonyourcomputerisinthepast.Ifyourcomputer'sclockshowsadatebefore1Jan1970,thebrowserwillautomaticallyforgetthecookie.Tofixthis,setthecorrecttimeanddateonyourcomputer.Youhaveinstalledanapplicationthatmonitorsorblockscookiesfrombeingset.Youmustdisabletheapplicationwhilelogginginorcheckwithyoursystemadministrator.WhyDoesthisSiteRequireCookies?Thissiteusescookiestoimproveperformancebyrememberingthatyouareloggedinwhenyougofrompagetopage.Toprovideaccesswithoutcookieswouldrequirethesitetocreateanewsessionforeverypageyouvisit,whichslowsthesystemdowntoanunacceptablelevel.WhatGetsStoredinaCookie?ThissitestoresnothingotherthananautomaticallygeneratedsessionIDinthecookie;nootherinformationiscaptured.Ingeneral,onlytheinformationthatyouprovide,orthechoicesyoumakewhilevisitingawebsite,canbestoredinacookie.Forexample,thesitecannotdetermineyouremailnameunlessyouchoosetotypeit.Allowingawebsitetocreateacookiedoesnotgivethatoranyothersiteaccesstotherestofyourcomputer,andonlythesitethatcreatedthecookiecanreadit.

Lymphoepithelioma-like carcinoma (LELC) primary to lung first described in 1987 by Bégin et al. · Previously considered subtype of large cell ...MenuChaptersBySubspecialtyBone,joints&softtissueBone&jointsSofttissueBreastClinicalpathologyChemistry,toxicology&UACoagulationHematologyLabadmin&managementMicrobiology¶sitologyMolecularmarkersTransfusionmedicineDermatopathologySkinmelanocytictumorSkinnonmelanocytictumorSkinnontumorGI/liverAnus&perianalAppendixColonEsophagusGallbladder&extrahepbileductsLiver&intrahepaticbileductsPancreasSmallintestine&ullaStomachGU/adrenalAdrenalgland¶gangliaBladder,ureter&renalpelvisKidneytumorPenis&scrotumProstategland&seminalvesiclesTestis&epididymisGynCervixFallopiantubes&broadligamentOvaryPlacentaPleura&peritoneumUterusVulva,vagina&femaleurethraHead&neckEarEyeLarynx,hypopharynx&tracheaMandible&maxillaNasalcavity&nasopharynxOralcavity&oropharynxSalivaryglandsThyroid¶thyroidHematopathologyBonemarrowneoplasticBonemarrownonneoplasticLymphnodes&spleen,nonlymphomaLymphoma&relateddisordersLung/heart/mediastinumHeartLungMediastinumPleura&peritoneumMedicalrenalNeuropathologyCNSnontumorCNStumorMuscle&peripheralnervenontumorOtherAutopsy&forensicsCytopathologyInformatics,digital&computationalStagingStains/CDmarkers/molecularMolecularmarkersStains&CDmarkersJobsFellowshipsConferences/WebinarsDirectoryLibrariesSampleLibraryCOVID-19LibraryPandemicreliefmusicawardMedicalNewsBooksBoardReviewQuestionsOtherLinksBlogCasesOnlineCMEDirectoryNewslettersAuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsCongratulationstoEmoryUniversity,MDAndersonandUniversityofRochester,ourDirectorysignupleaders.JobsFellowshipsConferences/WebinarsDirectoryBooksCMECasesAdvertiseGrantsCCNLibrariesSampleLibraryCOVID-19LibraryPandemicreliefmusicawardMedicalNewsHome>Lung>Lymphoepithelioma-likeLungOthercarcinomasLymphoepithelioma-likeAuthor: RoseannWu,M.D.,M.P.H.TopicCompleted:1January2018Minorchanges:11June2021Copyright:2003-2021,PathologyOutlin

We described a case of lymphoepithelioma-like carcinoma (LELC) of the lung of a 65-year-old man with initial symptoms of intermittent chest pain and mild ...CaseReportsinPulmonology+JournalMenuPDFJournaloverviewForauthorsForreviewersForeditorsTableofContentsSubmitCaseReportsinPulmonology/2013/ArticleArticleSectionsOnthispageAbstractIntroductionCaseReportDiscussionConclusionReferencesCopyrightCaseReport|OpenAccessVolume2013|ArticleID143405|https://doi.org/10.1155/2013/143405Yuan-ChunHuang,ChingHsueh,Shang-YunHo,Chiung-YingLiao,"Lymphoepithelioma-LikeCarcinomaoftheLung:AnUnusualCaseandLiteratureReview",CaseReportsinPulmonology,vol.2013,ArticleID143405,4pages,2013.https://doi.org/10.1155/2013/143405ShowcitationLymphoepithelioma-LikeCarcinomaoftheLung:AnUnusualCaseandLiteratureReviewYuan-ChunHuang,1,2ChingHsueh,1Shang-YunHo,1andChiung-YingLiao11DepartmentofMedicalImaging,ChanghuaChristianHospital,No.135NanxiaoStreet,Changhua500,Taiwan2DepartmentofRadiology,ChanghuaChristianHospital,ErlinBranch,No.558,Section1,DachengRoad,ErlinTownship,Changhua526,TaiwanShowmoreAcademicEditor:S.Al-SaadReceived28Aug2013Accepted19Sep2013Published30Oct2013Wedescribedacaseoflymphoepithelioma-likecarcinoma(LELC)ofthelungofa65-year-oldmanwithinitialsymptomsofintermittentchestpainandmildshortnessofbreathfor2weeks.Aright-lungmasswasnotedonchestcomputedtomography(CT)scanandwasprovedhistopathologicallyasLELCoflungaftervideo-assistedthorascopiclobectomy.Hewassuccessfullytreatedwithlobectomywithpostoperativeadjuvantchemotherapyandisalivewithoutsignsofrecurrencefor36monthsafterthediagnosis.Itisimportantforclinicians,pathologists,andradiologiststounderstandtheclinical,pathological,andradiologicalpresentationsofthisneoplasmtoavoidimproperclinicaldecisionmakingandmisdiagnosis.1.IntroductionLELCofthelungwasfirstreportedin1987[1].PrimaryLELCofthelungisarareentitythathasrecentlybeenincludedasasubtypeofvariantsoflargecellcarcinomaintheWorldHealthOrganization’shistologicclassificationoflungtumors[2].Beingara

Pulmonary lymphoepithelioma-like carcinoma is a rare and distinct subtype of non-small-cell lung cancer (NSCLC) associated with Epstein–Barr ...JournalsWhyPublishWithUs?EditorialPoliciesAuthorGuidelinesPeerReviewGuidelinesOpenOutlookCOVID-19BlogReprintsSubmitNewManuscriptMenuAboutContactSustainabilityAwardsPressCenterTestimonialsBlogFavoredAuthorProgramPermissionsPre-SubmissionReprintsLoginopenaccesstoscientificandmedicalresearchAdvancedsearchHomeJournalsWhypublishwithus?EditorialPoliciesAuthorInformationPeerReviewGuidelinesOpenOutlookCOVID-19AverageArticleStatistics21Days*Fromsubmissiontofirsteditorialdecision.13Days*Fromeditorialacceptancetopublication.*Businessdays(Mon-Fri)RejectionRate81%Theabovepercentageofmanuscriptshavebeenrejectedinthelast12months.67217PapersPublishedSubmitNewManuscriptLogintoviewexistingmanuscriptstatusSignupforJournalalertsAboutDovePressOpenaccesspeer-reviewedscientificandmedicaljournals.LearnmoreOpenAccessDoveMedicalPressisamemberoftheOAI.LearnmoreReprintsBulkreprintsforthepharmaceuticalindustry.LearnmoreFavoredAuthorsWeofferrealbenefitstoourauthors,includingfast-trackprocessingofpapers.LearnmorePromotionalArticleMonitoringRegisteryourspecificdetailsandspecificdrugsofinterestandwewillmatchtheinformationyouprovidetoarticlesfromourextensivedatabaseandemailPDFcopiestoyoupromptly.LearnmoreSocialMedia   BacktoJournals»OncoTargetsandTherapy»Volume13ReviewPulmonaryLymphoepithelioma-LikeCarcinoma:AMini-Review            FulltextMetricsGetPermissionCitethisarticleAuthorsHuY,RenS,LiuY,HanW,LiuWReceived6December2019Acceptedforpublication30March2020Published11May2020Volume2020:13Pages3921—3929DOIhttps://doi.org/10.2147/OTT.S241337CheckedforplagiarismYesReviewbySingleanonymouspeerreviewPeerreviewercomments2Editorwhoapprovedpublication:DrWilliamChoDownloadArticle[PDF] YanHu,1SiyingRen,2YukangLiu,1WeiHan,1WenliangLiu11DepartmentofThoracicSurgery,SecondXiangyaHospitalofCentralSouthUniversity,Changsha410011,People’sRepublicofChina;2DepartmentofRespiratory

Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma.SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearchOpenAccessPublished:21November2019Primarypulmonarylymphoepithelioma-likecarcinoma:araretypeoflungcancerwithafavorableoutcomeincomparisontosquamouscarcinomaBojiangChen1,XupingChen1,PingZhou1,LanYang1,JingRen1,XiaodongYang1&WeiminLi1 RespiratoryResearchvolume 20,Article number: 262(2019)Citethisarticle3081Accesses1AltmetricMetricsdetailsAbstractBackgroundPrimarypulmonarylymphoepithelioma-likecarcinoma(LELC)isararetumorandoftenmisdiagnosedassquamouscarcinoma.Inthecurrentstudy,clinicalcharacteristicsandoutcomeofprimarypulmonaryLELCweresystematicallycomparedwithpulmonarysquamouscarcinoma.MethodsForty-twocasesofprimarypulmonaryLELCand134squamouscarcinomaswereenrolledretrospectively.Characteristicandprognosisdifferencebetweenthetwogroupswascompared,andtheindependentprognosticfactorforpulmonaryLELCwasidentifiedaswell.ResultsIncomparisontosquamouscarcinoma,pulmonaryLELCwasmorecommoninwomenwithayoungermedianageandlesssmokers.LELCseemedtobesmallerindiameteroncomputedtomography(CT)scansthansquamouscarcinoma,withscarcespiculationandvascularconvergencesigns.Epstein-Barvirus-encodedRNA(EBER)byin-situhybridizationwasdetectedin33LELCcases,amongwhom27oneswerepositiveinserumEBV-DNAexamination.LELCpatientspresentedamuchlongermedianprogression-freesurvival(PFS)thansquamouscarcinoma.PositiveserumEBV-DNA,distantlymphnodeinvasion,advancedclinicalstageandreceivingradiotherapywerecorrelatedwiththeshorterPFSinLELCpatients.However,onlypositiveserumEBV-DNAwastheindependentPFSpredictor.ConclusionPulmonaryLELClookslikedistinctfromsquamouscarcinoma.Middle-agedwomenandnonsmokersarecomparativelypredominated.CTfeaturesofpulmonaryLELCarerelativelyless-malignant.Correspondently,theprogressionofpulmonaryLELCisseeminglyfavorablethansquamouscarcinomaandthepositiveserumEBV-DNAappearstobethepredictorofPFS.BackgroundL

Lymphoepithelioma-like carcinoma (LELC) of the lung was first reported in 1987. In the past two decades, there have been just more than 150 cases reported ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:16916325-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksWileyFulltextlinksActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstractSimilararticlesCited

LELC, an Epstein-Barr virus (EBV)-driven cancer, is more prevalent in the nasopharynx, but can originate from other organs such as the lung and gastrointestinal ...Home/Vol5,No6(December2016)/Metastaticlymphoepithelioma-likecarcinomaofthelungtreatedwithnivolumab:acasereportandfocusedreviewof...Metastaticlymphoepithelioma-likecarcinomaofthelungtreatedwithnivolumab:acasereportandfocusedreviewofliteratureCasepresentationMs.Yisa37-year-oldChinesefemalewithahistoryoflymphoepithelioma-likecarcinoma(LELC)ofthelungandhepatitisBvirusinfectionwhohasneversmoked.Shewasinitiallydiagnosedin2012withan8.6cmmassintheleftupperlobeandunderwenttwocyclesofneoadjuvantchemotherapywithcisplatinanddocetaxelfollowedbyleftupperlobectomyandmediastinallymphnodedissection.ThepathologicstageofdiseasewasstageIIIA(T3N2M0).Afterbeinglosttofollow-upfor2years,shepresentedtotheGeorgetownLombardiComprehensiveCancerCenterin2014withathree-monthhistoryofcough,shortnessofbreath,andupperbackpain.Apositronemissiontomography-computedtomography(PET-CT)scanshowedmultiple,bilateral[18F]-fluoro-2-deoxy-D-glucose(FDG)-avidpulmonarynodules,extensivehilarandmediastinallymphadenopathy,andmultipleskeletalmetastases.Amagneticresonanceimaging(MRI)ofthespineconfirmedthepresenceofosseousmetastaticdiseasethroughoutthevertebralcolumn.AbrainMRIshowednoevidenceofintra-cranialmetastasis.PathologicevaluationoftheresectedtumorconfirmedthediagnosisofLELCofthelung(Figure1).MolecularanalysesoftheoriginaltumorshowednoEGFR,ALKorKRASgeneticalterations.Initialtreatmentconsistedofdecompressionspinalcorpectomy(C7–T3)andpalliativeradiationtherapy(10fractions)toL2–L5metastaticlesionsfollowedbysystemicchemotherapywith6cyclesofcarboplatinandpemetrexed.Thetumorwasrefractorytochemotherapywithdiseaseprogressioninthebonesandlungsanddevelopmentofhepaticmetastases(Figure2A).Thenextlineoftreatmentconsistedofnivolumab3mg/kgadministeredintravenouslyevery2weeks.Tendaysafterthefirstdoseofnivolumab,thepatientdevelopedtachypneaandcoughthatwereconcerningfo

Primary pulmonary LELC is a rare malignant tumor which accounts for only 0.9% of all primary lung cancer (10,11) and only represents 0.4% of ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListOncolLettv.14(3);2017SepPMC5588446OncolLett.2017Sep;14(3):3110–3116.Publishedonline2017Jun30.doi: 10.3892/ol.2017.6510PMCID:PMC5588446PMID:28928848Primarylymphoepithelioma-likecarcinomaofthelung:Anunusualcancerandclinicaloutcomesof14patientsLanLin,1TingyanLin,1andBangweiZeng2LanLin1DepartmentofRespiratoryMedicine,FujianMedicalUniversityUnionHospital,Fuzhou,Fujian350001,P.R.ChinaFindarticlesbyLanLinTingyanLin1DepartmentofRespiratoryMedicine,FujianMedicalUniversityUnionHospital,Fuzhou,Fujian350001,P.R.ChinaFindarticlesbyTingyanLinBangweiZeng2DepartmentofHospitalInfectionManagement,FujianMedicalUniversityUnionHospital,Fuzhou,Fujian350001,P.R.ChinaFindarticlesbyBangweiZengAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimer1DepartmentofRespiratoryMedicine,FujianMedicalUniversityUnionHospital,Fuzhou,Fujian350001,P.R.China2DepartmentofHospitalInfectionManagement,FujianMedicalUniversityUnionHospital,Fuzhou,Fujian350001,P.R.ChinaCorrespondenceto:MissLanLin,DepartmentofRespiratoryMedicine,FujianMedicalUniversityUnionHospital,29XinquanRoad,Fuzhou,Fujian350001,P.R.China,E-mail:moc.361@2885373nalnilReceived2016Apr30;Accepted2017Apr13.Copyright©2017,SpandidosPublicationsThisarticlehasbeencitedbyotherarticlesinPMC.Advancedlungcancerisconsideredtoexhibitapoorprognosis;however,thepulmonarylymphoepithelioma-likecarcinoma(LELC),araresubtypeofnon-smallcelllungcancer(NSCLC),exhibitsanimprovedprognosis,comparedwithnon-LELC.Thepresentstudyaimedatinvestigatingtheclinicalmanifestation,imagingcharacteristics,pathology,tumormarkers,treatmentandprognosisofprimaryLELCofthelung.Atotalof14patientswithpulmonaryLELCwereconfirmedbysurgeryandpathology.Clinicaldataofthosepatientswereretrospecti

SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturenaturecommunicationsarticlesarticleThegenomiclandscapeofEpstein-Barrvirus-associatedpulmonarylymphoepithelioma-likecarcinomaDownloadPDFSubjectsCancergenomicsLungcancerAbstractPulmonarylymphoepithelioma-likecarcinoma(LELC)isarareanddistinctsubtypeofprimarylungcancercharacterizedbyEpstein-Barrvirus(EBV)infection.Herein,wereportedthemutationallandscapeofpulmonaryLELCusingwhole-exomesequencing,targeteddeepsequencingandsingle-nucleotidepolymorphismarrays.Weidentifyalowdegreeofsomaticmutationbutwidespreadexistenceofcopynumbervariations.Werevealpredominantsignature2mutationsandfrequentlossoftypeIinterferongenesthatareinvolvedinthehost-viruscounteraction.Integratedanalysisshowsenrichmentofgeneticlesionsaffectingseveralcriticalpathways,includingNF-κB,JAK/STAT,andcellcycle.Notably,multi-dimensionalcomparisonunveilsthatpulmonaryLELCresembleNPCbutareclearlydifferentfromotherlungcancers,naturalkiller/T-celllymphomaorEBV-relatedgastriccancerintermsofgeneticfeatures.Inall,ourstudyillustratesadistinctgenomiclandscapeofpulmonaryLELCandprovidesaroadmaptofacilitategenome-guidedpersonalizedtreatment.DownloadPDFIntroductionPulmonarylymphoepithelioma-likecarcinoma(LELC)isararesubtypeofprimarylungcancerthathistologicallyresemblesundifferentiatednasopharyngealcarcinoma(NPC)1.Firstreportedin1987,pulmonaryLELChasbeenrecognizedtobecloselyrelatedtoEpstein–Barrvirus(EBV)infection2,3.Inthe2015WorldHealthOrganization(WHO)ClassificationofLungTumors,pulmonaryLELCwasmovedfromlargecellcarcinomatootherandunclassifiedcarcinomas4.Comparedwithothertypesoflungcancers,pulmonaryLELChasdistinctclinicopathologicalfeatures.ItpreferentiallyaffectsAsiannon-smokersofyoungerageandhasintensivetumorinfiltra