Kleine-Levin syndrome (KLS), known also as recurrent hypersomnia or periodic ... and cognitive disturbances, hyperphagia and in some cases hypersexuality. ... and related symptoms are not better explained by another sleep disorder; other ...SearchKleine-LevinSyndromeYouarehere:HomeKleine-LevinSyndromeKleine-LevinSyndromeKleine-Levinsyndrome(KLS),knownalsoasrecurrenthypersomniaorperiodichypersomnolence,isararesleepdisorderwiththeprevalence1–2casespermillion,morefrequentlyfoundintheJewishpopulation.Themainfeaturesareintermittentperiodsofhypersomnolenceaccompaniedbybehavioralandcognitivedisturbances,hyperphagiaandinsomecaseshypersexuality.AccordingtoICSD-3,fourdiagnosticcriteriamustbemet:Thepatientexperiencesatleasttworecurrentepisodesofexcessivesleepinessandsleepduration,eachpersistingfor2daysto5weeks.Episodesrecurusuallymorethanonceayearandatleastonceevery18months.Thepatientmustdemonstrateatleastoneofthefollowingduringepisodes:CognitivedysfunctionAlteredperceptionEatingdisorder(hyperphagiaoranorexia)Disinhibitedbehavior(suchashypersexuality)Thehypersomnolenceandrelatedsymptomsarenotbetterexplainedbyanothersleepdisorder;othermedical,neurologic,orpsychiatricdisorders(especiallybipolardisorder);ortheuseofdrugsormedications.Theusualageatonsetisadolescencewithmalespredominating(sexratio2:1).ScrollThiswebsiteusescookiestoimproveyourexperience.We'llassumeyou'reokwiththis.AcceptReadMorePrivacy&CookiesPolicyClosePrivacyOverviewThiswebsiteusescookiestoimproveyourexperiencewhileyounavigatethroughthewebsite.Outofthese,thecookiesthatarecategorizedasnecessaryarestoredonyourbrowserastheyareessentialfortheworkingofbasicfunctionalitiesofthewebsite.Wealsousethird-partycookiesthathelpusanalyzeandunderstandhowyouusethiswebsite.Thesecookieswillbestoredinyourbrowseronlywithyourconsent.Youalsohavetheoptiontoopt-outofthesecookies.Butoptingoutofsomeofthesecookiesmayaffectyourbrowsingexperience.NecessaryNecessaryAlwaysEnabledNecessarycookiesareabsolutelyessentialforthewebsitetofunctionproperl

Kleine-Levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListNatSciSleepv.6;2014PMC3901778NatSciSleep.2014;6:19–26.Publishedonline2014Jan20.doi: 10.2147/NSS.S44750PMCID:PMC3901778PMID:24470783Kleine-Levinsyndrome:areviewMitchellGMiglisandChristianGuilleminaultMitchellGMiglisStanfordUniversitySleepMedicineDivision,StanfordOutpatientMedicalCenter,RedwoodCity,CA,USAFindarticlesbyMitchellGMiglisChristianGuilleminaultStanfordUniversitySleepMedicineDivision,StanfordOutpatientMedicalCenter,RedwoodCity,CA,USAFindarticlesbyChristianGuilleminaultAuthorinformationCopyrightandLicenseinformationDisclaimerStanfordUniversitySleepMedicineDivision,StanfordOutpatientMedicalCenter,RedwoodCity,CA,USACorrespondence:ChristianGuilleminault,StanfordUniversitySleepMedicineDivision,StanfordOutpatientMedicalCenter,450Broadway,RedwoodCity94063,CA,USA,Tel+16507236601,Emailude.drofnats@liugcCopyright©2014MiglisandGuilleminault.ThisworkispublishedbyDoveMedicalPressLimited,andlicensedunderCreativeCommonsAttribution–NonCommercial(unported,v3.0)LicenseThefulltermsoftheLicenseareavailableathttp://creativecommons.org/licenses/by-nc/3.0/.Non-commercialusesoftheworkarepermittedwithoutanyfurtherpermissionfromDoveMedicalPressLimited,providedtheworkisproperlyattributed.ThisarticlehasbeencitedbyotherarticlesinPMC.Kleine-Levinsyndromeisarecurrenthypersomniaassociatedwithsymptomsofhyperphagia,hypersexuality,andcognitiveimpairment.Thisarticlereviewsthecurrentavailableresearchanddescribescommonclinicalsymptoms,differentialdiagnosis,andacceptableworkupandtreatment.Althoughdeficitshavetraditionallybeenthoughttoresolvebetweenepisodes,functionalimagingstudiesandlong-termneuropsychologicaltestinginselectpatientshaverecentlychallengedthisnotion.ThismaysuggestthatKleine-Levinsyndromeisnotasbenignaspreviouslyconsidered.Keywords:Kleine-Levinsyndro