Disease may be asymptomatic to mild (80 % of cases), severe, or fatal(1,3,5,6,7). Early symptoms include gradual onset of fever, nausea, abdominal pain, severe ...FreeSafetyDataSheetIndexLassavirusLassavirusPATHOGENSAFETYDATASHEET-INFECTIOUSSUBSTANCESSECTIONI-INFECTIOUSAGENTNAME:Lassavirus.SYNONYMORCROSSREFERENCE:Lassafever,Lassafevervirus,viralhaemorrhagicfever(VHF)(1,2,3).CHARACTERISTICS:Double-segmented,single-strandedRNAvirus,belongingtothegenusArenavirus,familyArenaviridae.Theviralfragmentmayoccupyseveraldistinctshapes(pleomorphic)measuring80to150nmindiameter(1,4).ThesurfaceofthevirionlipidenvelopeisstuddedwithglycoproteinsthatconsistoftetramericcomplexesoftheviralglycoproteinsGP1andGP2(4).SECTIONII–HAZARDIDENTIFICATIONPATHOGENICITY/TOXICITY:Acuteviralillnessof1to4weeksduration(3).Diseasemaybeasymptomatictomild(80%ofcases),severe,orfatal(1,3,5,6,7).Earlysymptomsincludegradualonsetoffever,nausea,abdominalpain,severesorethroat,cough,conjunctivitis,ulcerationofbuccalmucosa,exudativepharyngitis,andcervicallymphadenopathy(1,3,5,7,8).Latesymptomsincludesevereswellingofheadandneck,pleuralandpericardialeffusions(8,9).Twenty-fivepercentofcasesresultindeafnessand/or(transient)alopecia(1,3,5,7,10).Thediseaseissevereinpregnancy,resultinginfoetallossin80%ofcases(3,10).DeathasaresultofinfectionwithLassavirusisusuallyduetocardiacarrest(1).Fatalityrateis15to20%ofhospitalizedpatientsand1to2%ofinfectedindividualsingeneral(1,3,7).EPIDEMIOLOGY:EndemicinWestAfrica.Between10,000and300,000infectionsoccurannuallywith5,000deaths(1,3,6,10).OutbreakshaveoccurredinGuinea,Liberia(1972),SierraLeone(1970-72,1973-75,and1996-97),areasofNigeria(firstcasesin1969,furtheroutbreaksin1970,1974,and1975),CentralAfricanRepublic,DemocraticRepublicofCongo,Mali,Senegal,Benin,BurkinaFaso,Cameroon,Ghana,IvoryCoastandSudan(1,3).Approximately20casesofimportedLassafeverhavebeenrecordedworldwide(11,12).HOSTRANGE:Mastomysnatalensis(anAfricanrodentalsoknownasthemultimammatemouseormultimammaterat)andhumans(1,3,4,7

What are Lassa fever symptoms and signs? · fever, · malaise, · generalized weakness, · sore throat (very similar to strep throat and without runny nose), · severe ...FactsLassafeverfactsWhatIsWhatisLassafever?WhatisthehistoryofLassafever?CausesWhatarecausesandriskfactorsforLassafever?ContagiousIsLassafevercontagious?Ifso,whatisthecontagiousperiodforLassafever?WhenisLassafevernolongercontagious?WhatistheincubationperiodforLassafever?Symptoms/SignsWhatareLassafeversymptomsandsigns?DiagnosisHowdophysiciansdiagnoseLassafever?TreatmentWhatisthetreatmentforLassafever?Risk/ComplicationsWhatarecomplicationsforLassafever?PrognosisWhatistheprognosisofLassafever?VaccineIsitpossibletopreventLassafever?IsthereavaccineforLassafever?ResearchWhatresearchisbeingdoneonLassafever?WherecanpeoplefindmoreinformationonLassafever?CenterLassaFeverCenterMoreFindalocalInfectiousDiseaseSpecialistinyourtownLassafeverfactsPictureofLassafevervirusstructureLassafeverisoneofthehemorrhagicfeverviruseslikeEbolavirus,Marburgvirus,andothers.UnlikeEbolavirus,Lassafeverisnotascontagiouspersontoperson,norasdeadly.LassavirusistypicallytransmittedbytheurineorfecesofMastomysratstohumans.Healthworkersmaybeinfectedbydirectcontactwithblood,bodyfluids,urine,orstoolofapatientwithLassafever.LassafeveroccursprimarilyinWestAfricainareaswheretheserodentslive.Lassafeveroutbreaksoccureveryyear.ThenumberofpeopleinfectedpeaksbetweenDecemberandJune.AlargeoutbreakwasreportedbytheNigeriaCentreforDiseaseControlthatbeganearlyin2018.WhatisLassafever?LassafeverisanillnesscausedbyLassavirus,asingle-strandedRNAhemorrhagicfevervirusfromthefamilyArenaviridae.Itisanacutefebrileviralillnesslastingonetofourweeks,anditoccursinWestAfricaandsomeareasbeyond.LassaFeverTreatment&MedicationRibavirin(Rebetol,Copegus,Ribasphere,RibaPak,Moderiba)Ribavirinisanantiviraldrug.ItisusedincombinationwithinterferonforthetreatmentofchronichepatitisC.Althoughtheexactmechanismofitsactionisunknown,itisthoughttointerferewiththeproductionand/oractionofviralD

homeinfectionscenterTopicGuideLassaFeverReviewedon2/7/2020WhatIsIt?FactsYouShouldKnowAboutLassaFeverWhatIsLassaFever?ContagiousHowDoesLassaFeverSpread?Symptoms/SignsWhatAreLassaFeverSymptomsandSigns?RiskFactorsWhatAreRiskFactorsforLassaFever?DiagnosisHowDoMedicalProfessionalsDiagnoseLassaFever?TreatmentWhatAreTreatmentsforLassaFever?Prevention/VaccineIsItPossibletoPreventLassaFever?GuideLassaFeverTopicGuideFactsYouShouldKnowAboutLassaFeverLassafeverisaviralinfectionthatspreadstohumanbythemultimammaterat.LassafeverfactswrittenbyMelissaConradStöppler,MDLassafeverisaviralinfectionfoundinEastAfrica,includingSierraLeone,Liberia,Guinea,andNigeria.TheLassafevervirusspreadsbyananimalreservoir,orhost,knownasthe"multimammaterat"(Mastomysnatalensis).Lassafeverspreadstohumansmostoftenthroughingestionorinhalationofvirusparticlesinraturine.Signsandsymptomsdevelopabout3weeksafterexposure.Associatedsignsandsymptomscanincludefever,weakness,headaches,vomiting,andmusclepains.About20%ofthoseaffectedhaveamoresevereillness.DeafnessisaknowncomplicationofLassafever.Ribavirinisanantiviraldrugthattreatstheinfection.ThereisnocurrentlyavailablevaccineforLassafever.LassaFeverShareYourStoryLassafeverisanacuteviralillnessthatoccursinwestAfrica.Theillnesswasdiscoveredin1969whentwomissionarynursesdiedinNigeria.ThevirusisnamedafterthetowninNigeriawherethefirstcasesoccurred.Thevirus,amemberofthevirusfamilyArenaviridae,isasingle-strandedRNAvirusandiszoonotic,oranimal-borne.LassafeverisendemicinpartsofwestAfricaincludingSierraLeone,Liberia,GuineaandNigeria;however,otherneighboringcountriesarealsoatrisk,astheanimalvectorforLassavirus,the"multimammaterat"(Mastomysnatalensis)isdistributedthroughouttheregion.In2009,thefirstcasefromMaliwasreportedinatravelerlivinginsouthernMali;Ghanareporteditsfirstcasesinlate2011.IsolatedcaseshavealsobeenreportedinCôted'IvoireandBurkinaFasoandthereisserologicevidenceofLassavirusinfectioninTogoandBenin.ThenumberofLassavirusinfectionsperyearinwestAfricaisestimatedat100,000to

Signs and symptoms of Lassa fever typically occur 1-3 weeks after the patient comes into contact with the virus. For the majority of Lassa fever ...SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkSkipdirectlytoA-ZlinkSkipdirectlytoA-ZlinkLassaFeverSectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateSignsandSymptomsFrenchMinusRelatedPagesSignsandsymptomsofLassafevertypicallyoccur1-3weeksafterthepatientcomesintocontactwiththevirus.ForthemajorityofLassafevervirusinfections(approximately80%),symptomsaremildandareundiagnosed.Mildsymptomsincludeslightfever,generalmalaiseandweakness,andheadache.In20%ofinfectedindividuals,however,diseasemayprogresstomoreserioussymptomsincludinghemorrhaging(ingums,eyes,ornose,asexamples),respiratorydistress,repeatedvomiting,facialswelling,paininthechest,back,andabdomen,andshock.Neurologicalproblemshavealsobeendescribed,includinghearingloss,tremors,andencephalitis.Deathmayoccurwithintwoweeksaftersymptomonsetduetomulti-organfailure.ThemostcommoncomplicationofLassafeverisdeafness.Variousdegreesofdeafnessoccurinapproximatelyone-thirdofinfections,andinmanycaseshearinglossispermanent.Asfarasisknown,severityofthediseasedoesnotaffectthiscomplication:deafnessmaydevelopinmildaswellasinseverecases.Approximately15%-20%ofpatientshospitalizedforLassafeverdiefromtheillness.However,only1%ofallLassavirusinfectionsresultindeath.Thedeathratesforwomeninthethirdtrimesterofpregnancyareparticularlyhigh.Spontaneousabortionisaseriouscomplicationofinfectionwithanestimated95%mortalityinfetusesofinfectedpregnantmothers.BecausethesymptomsofLassafeveraresovariedandnonspecific,clinicaldiagnosisisoftendifficult.Lassafeverisalsoassociatedwithoccasionalepidemics,duringwhichthecase-fatalityratecanreach50%inhospitalizedpatients.Pagelastreviewed:March25,2014Contentsource:CentersforDiseaseControlandPrevention,NationalCenterforEmergingandZoonoticInfectiousDiseases(NCEZID),DivisionofHigh-ConsequencePathogensandPathology(DHCPP),ViralSpecialPathogensBranch

Symptoms of Lassa fever begin with gradually progressive fever, weakness, malaise, and gastrointestinal symptoms (eg, nausea, vomiting, diarrhea, dysphagia, ...MSDManualPleaseconfirmthatyouareahealthcareprofessionalYesNoLeavethisSite?Thelinkyouhaveselectedwilltakeyoutoathird-partywebsite.Wedonotcontrolorhaveresponsibilityforthecontentofanythird-partysite.ContinueCancelhoneypotlinkHOMEMEDICALTOPICSCommonHealthTopicsCardiovascularDisordersClinicalPharmacologyCriticalCareMedicineDentalDisordersDermatologicDisordersEar,Nose,andThroatDisordersEndocrineandMetabolicDisordersEyeDisordersGastrointestinalDisordersGenitourinaryDisordersGeriatricsGynecologyandObstetricsHematologyandOncologyHepaticandBiliaryDisordersImmunology;AllergicDisordersInfectiousDiseasesInjuries;PoisoningMusculoskeletalandConnectiveTissueDisordersNeurologicDisordersNutritionalDisordersPediatricsPsychiatricDisordersPulmonaryDisordersSpecialSubjectsResourcesVideosFiguresImagesQuizzesViewAllResourcesRESOURCES3DModelsAbbreviationsLabTestsAudioCaseStudiesClinicalCalculatorsConversionTablesFiguresImagesLabValuesQuizzesTablesVideosNEWSAdjuvantNivolumabBeneficialinEsophageal,GEJunctionCancerAlcoholConsumptionLinkedtoLowerRiskforCataractSurgeryClinicalPreventiveServiceUseVariesAcrosstheUnitedStatesCOVID-19WasThirdLeadingCauseofDeathinUSin2020ViewAllNews>ViewAllNews>PROCEDURESTheVaginalExaminLaborUterineCompressionUterineBalloonTamponadeViewAllProcedures>ViewAllProcedures>QUIZZES&CASESQuizzesMoreQuizzesCasesMoreCaseStudiesABOUTOverviewHistoryEditorsandtheEditorialProcessPublishingandProductionStaffEditorialBoardContributorsReviewersContentProvidersGlobalMedicalKnowledgeFAQContactUsMedicalTopics&ChaptersABCDEFGHIJKLMNOPQRSTUVWXYZProfessional/InfectiousDiseases/Arboviruses,Arenaviridae,andFiloviridae/.../LassaFever/INTHISTOPICSymptomsandSignsDiagnosisPrognosisTreatmentPreventionKeyPointsOTHERTOPICSINTHISCHAPTERArboviruses,Arenaviridae,andFiloviridaeOverviewofArbovirus,Arenavirus,andFilovirusInfectionsDengueHantaviru

Lassa fever (LF) is a potentially severe viral hemorrhagic disease caused by Lassa virus and characterized by initial fever and malaise followed by gastrointestinal ...xShareShareRarediseasesSearchClinicalSignsandSymptomsClassificationsGenesDisabilityEncyclopaediaforpatientsEncyclopaediaforprofessionalsEmergencyguidelinesSources/proceduresHomepageRarediseasesSearchSearchforararedisease*(*)mandatoryfieldSearchDiseasenameORPHAcodeOMIMICD-10GenenameorsymbolOthersearchoption(s)AlphabeticallistSuggestanupdate(*)Requiredfields.Youare(*)Choose:HealthprofessionalPatient/Family/AssociationBiopharmaceuticalindustryScientistStudentOtherIfyouhaveselectedthe“Other”category,pleasespecifywhichtypeofuseryouare:*Emailaddress:*Topicofyourcomment*EpidemiologydataSummaryandrelatedtextsRelatedgenesClinicalsignsNomenclatureand/orcodingYourmessage*(3000charactersremaining)AttentionOnlycommentsseekingtoimprovethequalityandaccuracyofinformationontheOrphanetwebsiteareaccepted.Forallothercomments,pleasesendyourremarksviacontactus.OnlycommentswritteninEnglishcanbeprocessed.Orphanetdoesn'tprovidepersonalisedanswers.TogetintouchwiththeOrphanetteam,pleasecontactInformationprovidedinyourcontribution(includingyouremailaddress)willbestockedin.CSVfilesthatwillbesentasanemailtoOrphanet'steams.Theseemailsmightbeconservedintheteams'mailboxes,inourbackofficeserversbutwillnotberegisteredinourdatabases(formoreinformationseeoursectionGeneralDataProtectionRegulationanddataprivacy(GDPR)andConfidentiality).CheckthisboxifyouwishtoreceiveacopyofyourmessagePleasereproducethetextbelow:*LassafeverDiseasedefinitionLassafever(LF)isapotentiallysevereviralhemorrhagicdiseasecausedbyLassavirusandcharacterizedbyinitialfeverandmalaisefollowedbygastrointestinalsymptomsand,inseverecases,bleeding,shockandmulti-organsystemfailure.ORPHA:99824Classificationlevel:DisorderSynonym(s):LFLassahemorrhagicfeverPrevalence:<1/1000000Inheritance:-Ageofonset:AllagesICD-10:A96.2OMIM:-UMLS:C0023092MeSH:D007835GARD:-MedDRA:10023927SummaryEpid