Nipah virus was first identified in 1999 following a large outbreak affecting Malaysia and Singapore. The virus is one of eight categories of ...SkiptomaincontentAblackflyingfox(Pteropus)feedingonapalmtreeinQueensland,Australia.BatsandpalmscanbothcarryNipahvirustohumans.(AndrewMercerviaWikimediaCommons)SharethisstorySharethisstoryonfacebookSharethisstoryontwitterSharethisstoryonredditSharethisstoryonlinkedinGetthisstory'spermalinkPrintthisstoryLekshmySreekumar@dukenusSINGAPORE--NipahvirusexpertsandstakeholdersgatheredataninternationalconferenceinSingaporeDec.9and10tocommemoratethe20thanniversaryofthevirus’discoveryandtodiscussinnovativeandeffectivesolutionstocombatthethreattoglobalhealthsecurityposedbyNipah.Thetwo-daysessionwasco-hostedbyDuke-NUSMedicalSchool(Duke-NUS)andtheCoalitionforEpidemicPreparednessInnovations(CEPI).Nipahviruswasfirstidentifiedin1999followingalargeoutbreakaffectingMalaysiaandSingapore.ThevirusisoneofeightcategoriesofdiseasesthattheWorldHealthOrganizationhasidentifiedasepidemicthreatsinneedofprioritization.Overthepast20years,thevirushascontinuedtospreadoverthousandsofkilometerstoBangladeshandIndia.Theviruscausesseveredisease,includingrespiratorysymptomsandinflammationofthebrainleadingtocomaanddeath.RecordedmortalityratesinMalaysia,BangladeshandIndiaarebetween40and90percent.In2001,theviruswasdetectedinBangladeshandsincethen,frequentoutbreakshaveoccurredinthecountry.AnoutbreakinKerala,India,in2018claimed17lives.“TherearecurrentlynospecificdrugsorvaccinesforNipahvirusinfection,eventhoughtheWHOhasidentifiedNipahasaprioritydiseasefortheWHOResearchandDevelopmentBlueprint,”saidProfessorWangLinfa,directorofDuke-NUS’emerginginfectiousdiseases.“Throughtheconference,weaimtostimulatedialoguebetweenexpertsandstakeholderstobringaboutinnovativeandeffectivesolutionstoboosteffortsinfightingNipahvirus.”Nipahisazoonoticvirus,whichmeansthatitcanbespreadtohumansfromanimals.Itisspreadprimarilybybats(specificallyPteropusfruitbats)andpigs.Itcanalsobetransmittedthroug

NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListEmergInfectDisv.12(12);2006DecPMC3291367EmergInfectDis.2006Dec;12(12):1888–1894.doi: 10.3201/eid1212.060732PMCID:PMC3291367PMID:17326940FoodborneTransmissionofNipahVirus,BangladeshStephenP.Luby,*MahmudurRahman,†M.JahangirHossain,*LaurenS.Blum,*M.MushtaqHusain,†EmilyGurley,*RashedaKhan,*Be-NazirAhmed,†ShafiqurRahman,†NazmunNahar,*EbenKenah,*JamesA.Comer,‡andThomasG.Ksiazek‡StephenP.Luby*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyStephenP.LubyMahmudurRahman†InstituteforEpidemiologyDiseaseControlandResearch,Dhaka,Bangladesh;FindarticlesbyMahmudurRahmanM.JahangirHossain*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyM.JahangirHossainLaurenS.Blum*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyLaurenS.BlumM.MushtaqHusain†InstituteforEpidemiologyDiseaseControlandResearch,Dhaka,Bangladesh;FindarticlesbyM.MushtaqHusainEmilyGurley*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyEmilyGurleyRashedaKhan*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyRashedaKhanBe-NazirAhmed†InstituteforEpidemiologyDiseaseControlandResearch,Dhaka,Bangladesh;FindarticlesbyBe-NazirAhmedShafiqurRahman†InstituteforEpidemiologyDiseaseControlandResearch,Dhaka,Bangladesh;FindarticlesbyShafiqurRahmanNazmunNahar*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyNazmunNaharEbenKenah*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;FindarticlesbyEbenKenahJamesA.Comer‡CentersforDiseaseControlandPrevention,Atlanta,Georgia,USAFindarticlesbyJamesA.ComerThomasG.Ksiazek‡CentersforDiseaseControlandPrevention,Atlanta,Georgia,USAFindarticlesbyThomasG.KsiazekAuthorinformationCopyrightandLicenseinformationDisclaimer*InternationalCentreforDiarrhealDiseaseResearch,Dhaka,Bangladesh;†InstituteforEpidemiologyDiseaseContro

A vaccine for use against the deadly Nipah and Hendra viruses has ... and Hendra virus,” published in the journal, npj Vaccines, online February 8, 2021. ... outbreaks in humans and livestock in Australia, Malaysia, Singapore, ...FollowHome»Vaccines»Nipah,HendraVaccineforHumansEffective7DaysAfterImmunizationNipah,HendraVaccineforHumansEffective7DaysAfterImmunizationbyPressReleaseFebruary8,2021Vaccines1CommentAvaccineforuseagainstthedeadlyNipahandHendraviruseshasdemonstratedeffectivenessinpreclinicalstudiesasearlyas7daysfollowingasingleimmunization,accordingtoanewstudy,“ASingleDoseInvestigationalSubunitVaccineforHumanUseagainstNipahvirusandHendravirus,”publishedinthejournal, npjVaccines,onlineFebruary8,2021.PteropusfruitbatImage/VideoScreenShotAcollaborativegroupofinvestigatorsfromtheUniformedServicesUniversity(USU),theUniversityofTexasMedicalBranch(UTMB)andGalvestonNationalLaboratory(GNL),andProfectusBioSciences,Inc.(nowAuroVaccinesLLC),carriedouttwopreclinicalstudiesofaNipahandHendravirusvaccine. Theirresultsshowthatasubunitvaccineformulatedforuseinhumansiseffectiveasearlyasaweekafterthevaccinationisadministered.NipahvirusandHendravirusemergedinthe1990scausingseriousdiseaseoutbreaksinhumansandlivestockinAustralia,Malaysia,Singapore,BangladeshandIndia.RecentNipahoutbreakshaveresultedinacuterespiratorydistresssyndromeandencephalitis,person-to-persontransmission,andgreaterthan75percentcasefatalityratesamonghumans.ThevirusesarefoundnaturallyinseveralspeciesofPteropidfruitbats(flyingfoxes).TheNationalInstitutesofHealth(NIH)andCentersforDiseaseControlandPreventionhaveclassifiedNipahandHendraasbiothreatagents,andtheU.S.DepartmentofAgriculturehascharacterizedthemasagriculturethreatagents.InexperimentsconductedinnonhumanprimatesattheGNL,UTMB,Galveston,TX,wherethereisahigh-levelsafetyandsecurityfacilityforworkingwithliveNipahandHendraviruses,theteamofresearchers,underthedirectionofThomasGeisbert,Ph.D.,ProfessorintheDepartmentofMicrobiology&Immunology,demonstratedthatimmunizi

SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkNipahVirus(NiV)SectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateSignsandSymptomsMinusRelatedPagesInfectionwithNipahvirus(NiV)cancausemildtoseveredisease,includingswellingofthebrain(encephalitis)andpotentiallydeath.Symptomstypicallyappearin4-14daysfollowingexposuretothevirus.Theillnessinitiallypresentsas3-14daysoffeverandheadache,andoftenincludessignsofrespiratoryillness,suchascough,sorethroat,anddifficultybreathing.Aphaseofbrainswelling(encephalitis)mayfollow,wheresymptomscanincludedrowsiness,disorientation,andmentalconfusion,whichcanrapidlyprogresstocomawithin24-48hours.Symptomsmayinitiallyincludeoneorseveralofthefollowing:FeverHeadacheCoughSorethroatDifficultybreathingVomitingSeveresymptomsmayfollow,suchas:Disorientation,drowsiness,orconfusionSeizuresComaBrainswelling(encephalitis)Deathmayoccurin40-75%ofcases.Long-termsideeffectsinsurvivorsofNipahvirusinfectionhavebeennoted,includingpersistentconvulsionsandpersonalitychanges.Infectionsthatleadtosymptomsandsometimesdeathmuchlaterafterexposure(knownasdormantorlatentinfections)havealsobeenreportedmonthsandevenyearsafterexposure.Pagelastreviewed:October6,2020Contentsource:CentersforDiseaseControlandPrevention,NationalCenterforEmergingandZoonoticInfectiousDiseases(NCEZID),DivisionofHigh-ConsequencePathogensandPathology(DHCPP),ViralSpecialPathogensBranch(VSPB)homeNipahVirus(NiV)WhatisNipahVirus?TransmissionSigns&SymptomsDiagnosisTreatmentPreventionResourcesRelatedLinksAboutVSPB(ViralSpecialPathogensBranch)FacebookTwitterLinkedInSASstatsExitNotification/DisclaimerPolicyCloseLinkswiththisiconindicatethatyouareleavingtheCDCwebsite.TheCentersforDiseaseControlandPrevention(CDC)cannotattesttotheaccuracyofanon-federalwebsite.Linkingtoanon-federalwebsitedoesnotconstituteanendorsementbyCDCoranyofitsemployeesofthesponsorsortheinformationandproductspresentedonthewebsite.Youwillbesubjecttothedestinationwebsite'sprivacypolicywhenyoufollowthelink.CDCisnotre

The Nipah virus disease outbreak in 1998 was successfully ... of a more deadly Disease X to come in 2021 was raised in my previous column. ... An outbreak (11 cases, one death) was also reported in Singapore among ...×ViewRememberingtheNipahvirusoutbreakByDrMILTONLUMTheDoctorSaysTuesday,02Feb20211:00PMMYTRelatedNewsVietnam14hagoVietnamvaccinatesCovid-19front-linerswithitsfirstdosesWorld17hagoSouthKoreafindsnolinkfoundbetweendeathsandcoronavirusvaccineAseanPlusNews14hagoS.KoreafindsnolinkfoundbetweendeathsandcoronavirusvaccineWhilepigswerethemainsourceofinfectioninthefirstNipahoutbreakinMalaysia,fruitbatsalsoserveasahostforthevirusandhavebeenthesourceofmorerecentcases.—Photos:FilepicInDecember2015,theWorldHealthOrganization(WHO)cameoutwithalistofemergingdiseaseslikelytocausesevereoutbreaksinthenearfuture,andforwhichfewornomedicalcountermeasuresexist.ThelistincludedCrimeanCongohaemorrhagicfever,Ebolavirusdisease,Marburgvirusdisease,Lassafever,MERS(MiddleEasternrespiratorysyndrome),SARS(severeacuterespiratorysyndrome),Nipahvirus(NiV)disease,RiftValleyfeverandDiseaseX.DiseaseX“representedtheknowledgethataseriousinternationalepidemiccouldbecausedbyapathogencurrentlyunknowntocausehumandisease”.ThequestionofwhetherCovid-19isDiseaseXitselfortheprecursorofamoredeadlyDiseaseXtocomein2021wasraisedinmypreviouscolumn.RecentreportsoftheHealthMinistry’sstretchedresourcesincontainingCovid-19ledtoafeelingofdéjàvuasthesituationissimilartotheNiVoutbreakinMalaysiaandthequestionofwhetherNipahcouldbeDiseaseX.Malaysiawasthefirstcountryintheworldtoencounterthevirusin1998.Itresultedintheneardecimationofourpig-rearingindustry,whichwasthenthelargestinAsean,withaboutamillionpigsculled.Manyofthehumanswhosurvivedtheinfectionhavebeenleftwithresidualcomplications.InfectionNiVcausesseverediseaseinanimalsandcanspreadfromanimalstohumans.Thisisnotaforestfire,butsmokefromtheburningofculledpigsthatwereinfectedbytheNipahvirusatGertakSanggul,Penang,in2011.Itcanalsobespreadthroughcontaminatedfoodordirectly

Recently circulated reports have suggested that the Nipah virus has the ... Published: 31 January ,2021: 11:49 PM GST Updated: 01 February ,2021: ... by Nipah in the past include: Malaysia, Singapore, Bangladesh and India.....Acolorizedscanningelectronmicrographofanapoptoticcell(blue/green)heavilyinfectedwithSARS-COV-2virusparticles(yellow),isolatedfromapatientsample,capturedattheNIAIDIntegratedResearchFacility(IRF)inFortDetrick,Maryland.(AFP)Nipahvirusinfected600in17years,coronavirushit100millionin1year:WHOdataFollowFollowedUnfollowURLCopiedTuqaKhalid,AlArabiyaEnglishPublished:31January,2021:11:49PMGSTUpdated:01February,2021:02:56AMGSTURLCopiedRecentlycirculatedreportshavesuggestedthattheNipahvirushasthepotentialtobecomethenextglobalpandemic.However,databytheWorldHealthOrganization(WHO)showsthatNipahreportedlyinfectedonly600peoplein17years.TheNipahvirus,whichwasfirstidentifiedinanoutbreakinMalaysiain1998,infectedapproximately600peoplebetween1998and2015,accordingtoWHO.Visitourdedicatedcoronavirussitehereforallthelatestupdates.Meanwhile,thecoronavirusinfectedover100millionpeopleworldwideinayear'stime.Healthofficialswarnthenumberofconfirmedcasesisonlyafractionoftherealnumberofinfectionsaroundtheworld.TheWHOorganizationdefinesapandemicas"anepidemicoccurringworldwide,oroveraverywidearea,crossinginternationalboundariesandusuallyaffectingalargenumberofpeople."Nipah,azoonoticvirus-transmittedfromanimalstohumans,causesarangeofillnessesfromasymptomaticinfectiontoacuterespiratoryillnessandfatalencephalitis,accordingtoWHO.Themajoroutbreakswereduetotransmissionfrombatsandpigs.TheWHOhassaidin2018Nipahwasapublichealthconcernbecauseitinfectedawiderangeofanimalsandcausedseverediseaseanddeathinpeople.However,"NipahvirushascausedonlyafewknownoutbreaksinAsia,"itadded.CountrieswhichhavebeenaffectedbyNipahinthepastinclude:Malaysia,Singapore,BangladeshandIndia.Othercountries,WHOidentifiesas"maybeatriskforinfection"include:Cambodia,Ghana,Indonesia,Madagascar,thePhilippines,andThailand."In

SkipdirectlytositecontentSkipdirectlytopageoptionsSkipdirectlytoA-ZlinkNipahVirus(NiV)SectionNavigationCDCHomeFacebookTwitterLinkedInSyndicateTreatmentMinusRelatedPagesCurrentlytherearenolicensedtreatmentsavailableforNipahvirus(NiV)infection.Treatmentislimitedtosupportivecare,includingrest,hydration,andtreatmentofsymptomsastheyoccur.Thereare,however,immunotherapeutictreatments(monoclonalantibodytherapies)thatarecurrentlyunderdevelopmentandevaluationfortreatmentofNiVinfections.Onesuchmonoclonalantibody,m102.4,hascompletedphase1clinicaltrialsandhasbeenusedonacompassionateusebasis.Inaddition,theantiviraltreatmentremdesivirhasbeeneffectiveinnonhumanprimateswhengivenaspost-exposureprophylaxis,andmaybecomplementarytoimmunotherapeutictreatments.ThedrugribavirinwasusedtotreatasmallnumberofpatientsintheinitialMalaysianNiVoutbreak,butitsefficacyinpeopleisunclear.Pagelastreviewed:October6,2020Contentsource:CentersforDiseaseControlandPrevention,NationalCenterforEmergingandZoonoticInfectiousDiseases(NCEZID),DivisionofHigh-ConsequencePathogensandPathology(DHCPP),ViralSpecialPathogensBranch(VSPB)homeNipahVirus(NiV)WhatisNipahVirus?TransmissionSigns&SymptomsDiagnosisTreatmentPreventionResourcesRelatedLinksAboutVSPB(ViralSpecialPathogensBranch)FacebookTwitterLinkedInSASstatsExitNotification/DisclaimerPolicyCloseLinkswiththisiconindicatethatyouareleavingtheCDCwebsite.TheCentersforDiseaseControlandPrevention(CDC)cannotattesttotheaccuracyofanon-federalwebsite.Linkingtoanon-federalwebsitedoesnotconstituteanendorsementbyCDCoranyofitsemployeesofthesponsorsortheinformationandproductspresentedonthewebsite.Youwillbesubjecttothedestinationwebsite'sprivacypolicywhenyoufollowthelink.CDCisnotresponsibleforSection508compliance(accessibility)onotherfederalorprivatewebsite.FormoreinformationonCDC'swebnotificationpolicies,seeWebsiteDisclaimers.CancelContinue

No new cases reported in Singapore or Malaysia since then. Further outbreaks of Nipah virus infection have occurred elsewhere, mainly in western Bangladesh ...SharePointFollowContactUsFeedbackSitemapAboutNCIDNewsandEventsFacilities&ServicesCareersForPatientsandVisitorsForHealthcareProfessionalsForGeneralPublicForPatientsandVisitorsVisitaSpecialistAdmissionGettingtoNCIDFacilities&ServicesCost&FinancingPatients’Rights&ResponsibilitiesNCIDDoctorsForHealthcareProfessionalsDiseasesandConditionsResourcesonCOVID-19JointMOH/NCIDGuidancesInfectionControlGuidelinesforHealthcareFacilitiesCommunicableDiseasesSurveillanceinSingaporeWeeklyInfectiousDiseasesBulletinPandemicPreparednessUpdatesontheHIV/AIDSsituationinSingaporeSeminarsandConferencesGrantsandFellowshipsArticlesAntimicrobialResistanceForGeneralPublicDiseasesandConditionsFAQsonCOVID-19StayHealthyTravelHealth3DecadesofHIVTreatmentandCareattheCommunicableDiseaseCentreAntimicrobialResistanceNCIDYouTubeNCIDResearchStudiesA-AA+NCID>ForHealthcareProfessionals>DiseasesandConditions>NipahNipahNipahDiseasesandConditionsResourcesonCOVID-19JointMOH/NCIDGuidancesInfectionControlGuidelinesforHealthcareFacilitiesCommunicableDiseasesSurveillanceinSingaporeWeeklyInfectiousDiseasesBulletinPandemicPreparednessUpdatesontheHIV/AIDSsituationinSingaporeSeminarsandConferencesGrantsandFellowshipsArticlesAntimicrobialResistancePageContentCausativeAgentNipahvirus,Paramyxoviridaefamily.IncubationPeriod4-45daysInfectiousPeriodPossiblehuman-to-humantransmissionreportedinBangladesh.TransmissionViadirectcontactwithsecretions,tissuesorrespiratorydropletsofsickpigs.IngestionofrawfruitscontaminatedwithurineorsalivaofinfectedfruitbatsreportedinIndiaandBangladeshoutbreaks.ContactwithsecretionsandexcretionsofpatientsreportedasprobablemodeoftransmissioninBangladeshEpidemiologyAnewlydescribedhumanpathogen.ThefirsthumancasesoccurredinazoonoticencephaliticoutbreakbetweenSeptember1998andJune1999inMalaysiaandSingapore.Mortalitywasupto40%.BatsofthegenusPteropusar

Over the past 22 years, sporadic outbreaks of the Nipah virus, ... Published: 31 January ,2021: 02:43 PM GST Updated: 31 January ,2021: 03:28 PM GST ... During the first recognized outbreak in Malaysia, which also affected Singapore, most .......AstockimageofaNipahvirusoutbreakinIndia.(Filephoto:Reuters)Anewpandemic?Here’swhathappenedthelasttimeNipahvirusspreadAsiaFollowFollowedUnfollowURLCopiedJenniferBell,AlArabiyaEnglishPublished:31January,2021:02:43PMGSTUpdated:31January,2021:03:28PMGSTURLCopiedOverthepast22years,sporadicoutbreaksoftheNipahvirus,anemerginginfectiousdisease,haspromptedconcernamonginternationalvirologistsandhealthofficials.Firstrecognizedin1999duringanoutbreakamongpigfarmersinMalaysia,theviruswas,overthenextfewyears,reportedacrossAsiannations.ForallthelatestheadlinesfollowourGoogleNewschannelonlineorviatheapp.Thevirushasbeenthrustbackintothespotlight,followingareportbytheAccesstoMedicineFoundation.AsthewaragainsttheCOVID-19pandemicrageson,healthexpertsarewaryofthatNipahvirus(NiV)hasthepotentialtobecomeanewpandemic.ThereportstressesthattheNipahvirusdeservesattentionfromworldhealthexpertsasanoutbreakofthevirusinChina,withafatalityrateofupto75percent,couldpotentiallybethenextbigpandemicriskwithgiantpharmaceuticalcompaniesunpreparedwhilefocusingonCOVID-19.“Nipahvirusisanotheremerginginfectiousdiseasethatcausesgreatconcern.Nipahcouldblowanymoment.Thenextpandemiccouldbeadrug-resistantinfection,”TheGuardianquotedJayasreeKIyer,theexecutivedirectoroftheNetherlands-basedAccesstoMedicineFoundation,assaying.Butwhatisthevirus?Transmittedfromanimalstohumans,thevirusisfoundincontaminatedfood.People,onceinfectedwithNipahcanpassontoothers.Ininfectedpeople,accordingtotheWorldHealthOrganization(WHO),itcausesarangeofillnessesfromasymptomatic(subclinical)infectiontoacuterespiratoryillnessandorfatalcausesofencephalitis,orinflammationofthebrain.Theusualtreatmentissupportivecare.Thennipahvirus(iFilephoto)DuringthefirstrecognizedoutbreakinMalaysia,whichalsoaffectedSingapo