Severe complications of scrub typhus include pneumonia, acute respiratory distress syndrome, myocarditis, hepatic failure, gastrointestinal ...MetricsLinksFilesGotoClinicalandLaboratoryPredictorsassociatedwithComplicatedScrubTyphusOriginalArticle  OpenAccessInfectChemother.2019Jun;51(2):161-170.English.PublishedonlineJun27,2019.  https://doi.org/10.3947/ic.2019.51.2.161Copyright©2019byTheKoreanSocietyofInfectiousDiseasesandKoreanSocietyforAntimicrobialTherapyClinicalandLaboratoryPredictorsassociatedwithComplicatedScrubTyphusMi-HeeKim,Si-HyunKim,Jung-HyunChoiandSeong-HeonWieDivisionofInfectiousDiseases,DepartmentofInternalMedicine,CollegeofMedicine,TheCatholicUniversityofKorea,Seoul,Korea.CorrespondingAuthor:Seong-HeonWie,MD,PhD.DepartmentofInternalMedicine,St.Vincent'sHospital,CollegeofMedicine,TheCatholicUniversityofKorea,93Jungbu-daero,Paldal-gu,Suwon16247,Korea.Tel:+82-31-881-8851,Fax:+82-31-253-8898,Email:[email protected],2019;AcceptedMay29,2019.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionNon-CommercialLicense(https://creativecommons.org/licenses/by-nc/4.0/)whichpermitsunrestrictednon-commercialuse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Thisarticlehasbeencitedby4articlesin   ThisarticlehasbeencitedbyGoogle Scholar. Thisarticlehasbeencitedby1articlein PubMedCentral.Goto:AbstractBackgroundScrubtyphus,amite-bornediseasecausedbybitesofOrientiatsutsugamushi-infectedchiggers,isendemicinAsia-Pacificcountries.InKorea,itisaseasonaldiseaseprevalentinautumnandoneoftheimportantcausesofacuteundifferentiatedfebrileillness.Thepurposeofthisstudywastoidentifytheriskfactorsforthepredictionofthesevereclinicalcourseofscrubtyphusandtoinvestigatethedifferencesintheclinicalandlaboratoryfindingsofhospitalizedelderlyandnon-elderlypatientswithscrubtyphus.MaterialsandMethodsThisstudyretrospectivelyreviewedthemedicalrecordsofpatientsdiagnosedwithscrubtyphus.ResultsAtotalof710patientswereenrolledand43.

EditionININUSSignInTOICitychennaimumbaidelhibengaluruHyderabadkolkataagraagartalaahmedabadajmerallahabadamaravatiamritsaraurangabadbareillybhubaneswarbhopalchandigarhcoimbatorecuttackdehradunerodefaridabadghaziabadgoagurgaonguwahatihubballiimphalindoreitanagarjaipurjammujamshedpurjodhpurkanpurkochikohimakolhapurkozhikodeludhianalucknowmaduraimangalurumeerutmumbairegionmysurunagpurnashiknavimumbainoidapatnapuducherrypuneraipurrajkotranchithanesalemshillongshimlasrinagarsurattrichythiruvananthapuramudaipurvadodaravaranasivijayawadavisakhapatnamcivicissuescrimepoliticsschoolandcollegestamilnaduelectionscitizenreportervideosphotosweatherpollutionnewseventsScrubTyphus,thekillerdisease,comestotownTopSearchesTamilNaduNewsPuducherryCovidCasesTamilNaduLocalBodyElection2021CovidvaccineregistrationChennaiAxisBankIFSCCodeSBIChennaiIFSCCodeNewsCityNewschennaiNewsScrubTyphus,thekillerdisease,comestotownThisstoryisfromJanuary10,2012ScrubTyphus,thekillerdisease,comestotownPushpaNarayan/TNN/Updated:Jan10,2012,12:33ISTFacebookTwitterLinkedinEMailAA+TextSizeSmallMediumLargeARTICLESScrubTyphus,thekillerdisease,comestotownBloodystarttotheNewYearinChennai:Ninemurdersin9daysTheairyou’rebreathingindoorsisdirtierthanyouthinkMangetsreliefforbrokenfurnitureForalmostsixdays,Kamya'sparentswonderedwhyherfeverdidnotcomedowndespitetakingmedicinesincludingsomeexpensiveantibiotics.Lastweek,shediedatApolloHospitalsfollowingmultiorganfailure.Itwasonlywhenadoctorattheintensivecareunitnoticedatinyblackscaronherthigh,sheknewKamya'sdisease-scrubtyphus,ararezoonoticdisease(whichcanbetransmittedfromanimalstohumans).Doctorssaythediseaseiscurableusingantibiotics,butitcangetoutofhandwhendiagnosisisdelayed."Kamyawasreferredtousverylate,"saidadoctor.InDecember2011,doctorssawatleastthreeverysickchildrenwithscrubtyphus.Allofthemhadtobeventilated,andoneofthemrequireddialysis."Thisisdengueseason.Therewerefourpatientswithdengue,buttheyweren'tassick.Theyweredischargedinthreedays,butthosewithscrubtyphuswerehereforatlea

Scrub typhus patients who are not treated may develop serious complications and may even die. Mortality ranges from 1% to 60%, depending on ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL2VtZWRpY2luZS5tZWRzY2FwZS5jb20vYXJ0aWNsZS85NzE3OTctY2xpbmljYWw=processing....Drugs&Diseases>Pediatrics:GeneralMedicineScrubTyphus ClinicalPresentationUpdated:Apr19,2018Author:DavidJCennimo,MD,FAAP,FACP,FIDSA,AAHIVS;ChiefEditor:RussellWSteele,MD more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsScrubTyphusSectionsScrubTyphusOverviewPracticeEssentialsBackgroundPathophysiologyEtiologyEpidemiologyPrognosisShowAllPresentationHistoryPhysicalExaminationComplicationsShowAllDDxWorkupTreatmentApproachConsiderationsPharmacologicTreatmentPreventionShowAllMedicationMedicationSummaryAntibioticsShowAllQuestions&AnswersMediaGalleryReferencesPresentationHistoryPatientswithscrubtyphusmaypresentearlyorlaterinthecourseoftheirdisease.IntheUnitedStates,ahistoryoftraveltotheendemicareamustbesought,specificallyprobingforexposuresinruralareasandcontactwithvegetationortheground.[3,6,13]Inoculationthroughthechiggerbiteisoftenpainlessandunnoticed.Theincubationperiodlasts6-20days(average,10days).Afterincubation,personsmayexperienceheadaches,shakingchills,lymphadenopathy,conjunctivalinfection,fever,anorexia,andgeneralapathy.Thefeverusuallyreaches40-40.5°C(104-105°F).Asmallpainlesspapuleinitiallyappearsatthesiteofinfectionandenlargesgradually.Anareaofcentralnecrosisdevelopsandisfollowedbyescharformation.The

Reported severe clinical manifestations or complications of scrub typhus include interstitial pneumonia, acute renal failure, ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearcharticleOpenAccessPublished:30April2010ClinicalandlaboratoryfindingsassociatedwithseverescrubtyphusDong-MinKim1,3,SeokWonKim2,Seong-HyungChoi1&NaRaYun1 BMCInfectiousDiseasesvolume 10,Article number: 108(2010)Citethisarticle9976Accesses103CitationsMetricsdetailsAbstractBackgroundScrubtyphusisamite-bornebacterialinfectionofhumanscausedbyOrientiatsutsugamushithatcausesageneralizedvasculitisthatmayinvolvethetissuesofanyorgansystem.Theaimofthisstudywastoidentifyfactorsassociatedtoseverecomplicationsfromscrubtyphus.MethodsWeconductedthisprospective,case-controlstudyonscrubtyphuspatientswhopresentedtotheDepartmentofInternalMedicineatChosunUniversityHospitalbetweenSeptember,2004andDecember,2006.Caseswere89scrubtyphuspatientswithseverecomplicationsandcontrolswere119scrubtyphuspatientswithoutseverecomplications.ResultsThereweresignificantdifferencesintheabsenceofeschar,whitebloodcell(WBC)counts,hemoglobin,albumin,serumcreatinine,fibrinogen,C-reactiveprotein(CRP),andactivepartialthromboplastintime(aPTT)betweenthetwogroups.Multivariateanalysisdemonstratedthatonlythefollowingfourfactorsweresignificantlyassociatedwiththeseverecomplicationsofscrubtyphus:(1)age≥60years(oddratio[OR]=3.13,P=0.002,confidenceinterval[CI]=1.53-6.41),(2)theabsenceofeschar(OR=6.62,P=0.03,CI=1.22-35.8,(3)WBCcounts>10,000/mm3(OR=3.6,P=0.001,CI=1.65-7.89),and(4)albumin≤3.0g/dL(OR=5.01,P=0.004,CI=1.69-14.86).ConclusionsOurresultssuggestthatcliniciansshouldbeawareofthepotentialforcomplications,whenscrubtyphuspatientsareolder(≥60years),presentswithouteschar,orlaboratoryfindingssuchasWBCcounts>10,000/mm3,andserumalbuminlevel≤3.0g/dL.Closeobservationandintensivecareforscrubtyphuspatientswiththepotentialforcomplicationsmaypreventseriouscomplicationswithsubsequentreductioninitsmortalityrate.PeerReviewreportsBackgrou

Serious complications included pneumonitis 36% (12/33), acute respiratory distress syndrome (ARDS) 15% (5/33), acute renal failure 9% (3/33), myocarditis 3% (1/ ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:10496165-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstractSimilararticlesCitedbyMeSHtermsSubstancesRela

ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointSpecialty:MultispecialtyAllergy&ImmunologyAnesthesiologyBusinessofMedicineCardiologyCriticalCareDermatologyDiabetes&EndocrinologyEmergencyMedicineFamilyMedicineGastroenterologyGeneralSurgeryHematology-OncologyHIV/AIDSHospitalMedicineInfectiousDiseasesInternalMedicineMultispecialtyNephrologyNeurologyOb/Gyn&Women'sHealthOncologyOphthalmologyOrthopedicsPathology&LabMedicinePediatricsPlasticSurgeryPsychiatryPublicHealthPulmonaryMedicineRadiologyRheumatologyTransplantationUrologyMedicalStudentsNursesPharmacistsResidentsTodayonMedscapeEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsFriday,September17,2021ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoDecisionPointclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vYW5zd2Vycy85NzE3OTctMjAxNzI4L3doYXQtYXJlLXRoZS1wb3NzaWJsZS1jb21wbGljYXRpb25zLW9mLXNjcnViLXR5cGh1cw==processing....Drugs&Diseases>Pediatrics:GeneralMedicine>ScrubTyphusQ&AWhatarethepossiblecomplicationsofscrubtyphus?Updated:Apr19,2018Author:DavidJCennimo,MD,FAAP,FACP,AAHIVS;ChiefEditor:RussellWSteele,MD more...ReferencesShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+AnswerScrubtyphuspatientswhoarenottreatedmaydevelopseriouscomplicationsandmayevendie.Mortalityrangesfrom1%to60%,dependingonthegeographicareaandthepathogenicstrain.Deathcanoccureitherfromtheprimaryinfectionorfromsecondarycomplications(eg,pneumonitis,encephalitis,orcirculatoryfailure).Mostfatalitiesoccurbytheendofthesecondweekofinfection.Scrubtyphushasanincreasedpotentialforcomplicationswhenpatientsareolderthan60years,presentwithouteschar,orhavewhitebloodcell(WBC)countshigherthan10,000/μL.[41]Thisco

The most common complications were myocarditis (72.4%), hypoalbuminemia (71.1%), severe thrombocytopenia (22.4%), renal impairment (65.8%), ...BrowseSubjectAreas?ClickthroughthePLOStaxonomytofindarticlesinyourfield.FormoreinformationaboutPLOSSubjectAreas,clickhere.ArticleAuthorsMetricsCommentsMediaCoverageReaderComments(0)FiguresFiguresAbstractBackgroundScrubtyphus,animportantcauseofunexplainedfever,isgrosslyneglectedandoftenmisdiagnosedinlowandmiddleincomecountrieslikeNepal.ThemainaimofthisstudywastoreportontheclinicalprofileandcomplicationsofscrubtyphusanditsoutcomeinNepalesechildren.MethodsAprospectiveobservationalstudywascarriedoutinchildrenaged1–16years,admittedtoatertiarycarehospitalofcentralNepalinbetweenJuly2016-Aug2017.ScrubtyphuswasdiagnosedwithIgMELISA.ResultsAllcasesofscrubtyphus(n=76)presentedwithfeverandcommonlyhadothersymptomssuchasheadache(75%),myalgia(68.4%),vomiting(64.5%),nausea(59.2%),abdominalpain(57.9%),cough(35.5%),shortnessofbreath(22.4%),alteredsensorium(14.5%),rashes(13.2%)andseizures(11.8%).Importantclinicalsignsnoticedwerelymphadenopathy(60.5%),hepatomegaly(47.4%),edema(26.3%),jaundice(26.3%),andsplenomegaly(15.8%).About12%(n=9)hadnecroticeschar.Similarly,thrombocytopenia,raisedliverenzymesandraisedcreatininevalueswereseenin36.9%,34.2%and65.8%respectively.Themostcommoncomplicationsweremyocarditis(72.4%),hypoalbuminemia(71.1%),severethrombocytopenia(22.4%),renalimpairment(65.8%),hyponatremia(48.7%)andhepatitis(34.2%).Overtwo-thirds(69.70%)ofthecasesweretreatedwithdoxycyclinefollowedbycombinationwithazithromycinintheremaining18.4%.Overall,mortalityrateinthisgroupwas3.9%.ConclusionsScrubtyphusshouldbeconsideredasadifferentialinanycommunityacquiredacuteundifferentiatedfebrileillnessregardlessofthepresenceofaneschar.Myocarditisandacutekidneyinjuryareimportantcomplicationswhichwhenaddressedearlycanpreventmortality.Useofdoxycyclineshowedafavorableoutcome.Citation:PathakS,ChaudharyN,DhakalP,ShakyaD,DhungelP,NeupaneG,etal.(2019)Clinicalprofile,com

Scrub typhus should be considered as a differential in any community acquired acute undifferentiated febrile illness regardless of the ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:31408484-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksPublicLibraryofScienceFreePMCarticleFulltextlinksActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstractConflicto

 HomeAboutusEditorialboardAheadofprintCurrentissueArchivesSubmitarticleGuidelinesContactsLogin ISSN:Print-2349-0977,Online-2349-4387AdvancedSearch   ORIGINALCONTRIBUTION:CLINICSININFECTIOUSDISEASESYear:2015 | Volume:2 | Issue:3 | Page:116-120Clinicalmanifestationsandcomplicationsofscrubtyphus:Ahospital-basedstudyfromNorthAndhraNrushenPeesapati,RohitLakkapragada,SSunitha,PVSivaramDepartmentofGeneralMedicine,TirumalaHospital,Vizianagaram,AndhraPradesh,IndiaDateofWebPublication2-May-2016CorrespondenceAddress:NrushenPeesapatiMIG170,VudaPhase4,Vizianagaram-535003,AndhraPradeshIndiaSourceofSupport:None,ConflictofInterest:NoneCheckDOI: 10.4103/2349-0977.181508  Abstract AimsandObjectives:Todescribethediversityofclinicalmanifestations,laboratoryfindings,andoutcomeofscrubtyphusinhospitalizedpatientsofTirumalaHospital,Vizianagaram,during2014–2015.MaterialsandMethods:Allcasesofacutefebrileillnessdiagnosedasscrubtyphuswereanalyzed.DiagnosiswasmadebyELISA-basedIgMserology.ObservationsandResults:Atotalofsixtypatientswereincludedinthestudy.Allofthempresentedwithfever;theothermajorsymptomswereheadache,cough,dyspnea,andmyalgias.Onexamination,patientshadhepatosplenomegaly,lymphadenopathy,andeschar.Oninvestigation,elevatedserumglutamic-oxaloacetictransaminase,serumglutamicpyruvictransaminasewithnormalandelevatedbilirubinlevelswerethemostcommonfindings.Otherlaboratoryfindingswerethrombocytopeniaandderangedrenalfunctiontests.Othercomplicationsweremultiorgandysfunctionsyndrome,acuterespiratorydistresssyndrome,hypotension,andmeningoencephalitis.Majorityrespondedtodoxycycline.Conclusion:Scrubtyphusthoughprevalentisunder-reportedinourcountry.Itshouldbeconsideredasanimportantdifferentialdiagnosisinafebrilepatientwiththrombocytopenia,derangedliverorrenalfunctions,Earlydiagnosisandappropriatetreatmentisrewardingandpreventsmorbidityandmortality.Keywords: Complications,clinicalfeatures,scrubtyphus,treatmentHowtocitethisarticle:PeesapatiN,LakkapragadaR,SunithaS,SivaramPV.Clinicalmanifestationsand