HealthConditionsDiscoverPlanConnectSubscribeStage4Lymphoma:Facts,Types,Symptoms,andTreatmentMedicallyreviewedbyEunaChi,M.D.—WrittenbyTreacyColbert—UpdatedonNovember12,2018TypesSymptomsTreatmentOutlookTakeawayFightanxietywithknowledgeAdiagnosisof“stage4lymphoma”mightbedifficulttoaccept.Butit’simportanttoknowthatsometypesofstage4lymphomamaybecurable.Youroutlookdepends,inpart,onthetypeofstage4lymphomathatyouhave.Readmoretolearnaboutdifferentlymphomasubtypes,includingthetreatmentoptionsandlong-termoutlookforHodgkin’slymphomaandnon-Hodgkin’slymphoma.TypesoflymphomaLymphomaisn’tasingledisease.Thetermreferstoagroupofbloodcancersthatcandevelopinyourlymphaticsystem.Therearetwomaintypesoflymphoma:Hodgkin’slymphomanon-Hodgkin’slymphoma(NHL)Ifyou’rediagnosedwithlymphoma,yourdoctorwillperformteststolearnwhatstageofthediseaseyouhave.Stage4isthemostadvancedstageoflymphoma.Thecharacteristicsofstage4lymphomavary,dependingonthesubtypeoflymphomayouhave.Hodgkin’slymphomaAccordingtoestimatesfromtheAmericanCancerSociety(ACS),about8,500newcasesofHodgkin’slymphomawillbediagnosedintheUnitedStatesin2016.Hodgkin’slymphomaistreatable,especiallyinitsearlystages.Theone-yearsurvivalrateforallpatientsdiagnosedwithHodgkin’slymphomaisabout92percent.Thefive-yearsurvivalrateisabout86percent.Forpeoplewithstage4Hodgkin’slymphoma,thesurvivalrateislower.Buteveninstage4youcanbeatthedisease.IfyouhaveHodgkin’slymphomathat’sspreadthroughoneormoreorgansoutsideofyourlymphaticsystem,you’llbediagnosedwithstage4ofthecondition.Forexample,thecancermighthavespreadtoyourliver,lungs,orbonemarrow.Non-Hodgkin’slymphoma(NHL)NHLaccountsforabout4percentofallcancersintheUnitedStates,reportstheACS.Anestimated72,580peopleinthecountrywillbediagnosedwithitin2016.ThemanysubtypesofNHLarecategorizedaseitherBcelltypeorTcelltypeNHL.Thesubtypesarefurthercategorizedasaggressiveorindolent.AggressiveNHLprogressesquickly.AccordingtotheLeukemiaandLymphomaSociety(LLS),about60percentofpeoplewithNHLhaveaggressivesubtypesofthedisease.Diffusela