AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsSeeElsevier'snewvideoabouttheirClinicReviewArticlesonourhomepageorclickhere.JobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Lung>SynovialsarcomaLungMesenchymaltumorsSynovialsarcomaAuthor: DeepaliJain,M.D.TopicCompleted:1September2012Minorchanges:16September2020Copyright:2003-2021,PathologyOutlines.com,Inc.PubMedSearch:pulmonarysynovialsarcomaPageviewsin2020:2,497Pageviewsin2021todate:841TableofContentsDefinition/general|Casereports|Microscopic(histologic)description|Positivestains|Negativestains|Molecular/cytogeneticsdescription|DifferentialdiagnosisCitethispage:JainD.Synovialsarcoma.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/lungtumorsynovialsarcoma.html.AccessedApril13th,2021.Definition/generalRaretumorinlungAssociatedwithchestpain,hemoptysis,dyspnea,cough,feverRarelyiscystic(AmJSurgPathol2010;34:1176)40-55%dieofdiseaseafter20yearsfollowup,duetometastasestobone,CNS,liver,orinvasionofadjacentorgansTumorswithSYT-SSX2fusionproteinshave89%5yearsurvivalvs.42%fortumorswithSYT-SSX1fusionproteinCasereports45yearoldwomanwithSYT-SSX2andrapidlyprogressivecourse(ArchPatholLabMed2003;127:e201)72yearoldwhitemanwithpoorlydifferentiatedtumorwithrhabdoidfeatures(ArchPatholLabMed2003;127:e160)Microscopic(histologic)descriptionMonophasicspindlecellsorbiphasicwithepithelialandspindlecellcomponentMonophasictumorshavecompactfasciclesofhyperchromaticspindlecellswithhemangiopericytoma-likeareas,oftenpunctuatedbysmallarteriesandcapillariesinanirregulardistributionPoorlydifferentiatedtumorshavesmall,roundbluecellsresemblingEwingsarcoma/PNETRarelyrhabdoidfeaturesPositivestainsTLE1highlyspecific(VirchowsArch2011;459:615)NegativestainsCD117(mostcases)TestMolecular/cytogeneticsdescriptiont(X;18)(p11.2;icq11.2)ProduceseitherSYT-SSX1orSYT-SSX2fusiongenesDifferenti