A single dose investigational subunit vaccine for human use against ... | Nipah virus Singapore

SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturenpjvaccinesarticlesarticleAsingledoseinvestigationalsubunitvaccineforhumanuseagainstNipahvirusandHendravirusDownloadPDFSubjectsProteinvaccinesViralinfectionAbstractNipahandHendravirusesarehighlypathogenicbat-borneparamyxovirusesrecentlyincludedintheWHOBlueprintprioritydiseaseslist.Afullyregisteredhorseanti-HendravirussubunitvaccinehasbeeninuseinAustraliasince2012.Basedonthesameimmunogen,theHendravirusattachmentglycoproteinectodomain,asubunitvaccineformulationforuseinpeopleisnowinaPhaseIclinicaltrial.WereportthatasingledosevaccinationregimenofthishumanvaccineformulationprotectsagainstotherwiselethalchallengesofeitherHendraorNipahvirusinanonhumanprimatemodel.TheprotectionagainsttheNipahBangladeshstrainbeginsassoonas7dayspostimmunizationwithlowdoseof0.1 mgproteinsubunit.OurdatasuggestthishumanvaccinecouldbeutilizedasefficientemergencyvaccinetodisruptpotentialspreadingofNipahdiseaseinanoutbreaksetting.DownloadPDFIntroductionNipahvirus(NiV)andHendravirus(HeV)areenveloped,single-strandednegative-senseRNAvirusesandtheprototypemembersofthegenusHenipavirusinthefamilyParamyxoviridae1.NiVandHeVarebat-bornedisease-causingzoonoses,andPteropusbats(flyingfoxes)aretheirmajornaturalreservoirhostsalthoughevidenceinotherbatsexists2.Inseveralanimalspeciesandinpeople,themajorpathologicalobservationsofNiVandHeVinfectionisaseveresystemicandoftenfatalneurologicand/orrespiratorydisease3,4,5.Inaddition,bothNiVandHeVcanalsocauserelapsingencephalitis,fromseveralmonthstomorethan10yearslater,followingarecoveryfromanacuteinfectionasaresultofrecrudescenceofvirusreplicationinthecentralnervoussystem(CNS)6,7.NiVandHeVarealsodistinguishedbytheirexceptionallybroadspeciestropismandcancausedisea

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Lessons to be learnt from the Nipah virus outbreak in ... | Nipah virus Singapore
Lessons to be learnt from the Nipah virus outbreak in Singapore. < Back to Listing. Share this Article. Singapore Med J 1999; 40(5):331-2. Lessons to be learnt ...
Nipah virus at 20 | Nipah virus Singapore
The next year the disease spread to abattoir workers in Singapore. The movement of the disease was a consequence of transport of pigs from ...
Nipah virus infection | Nipah virus Singapore
In Malaysia and Singapore, Nipah virus infected people with close contact to infected pigs. In Bangladesh and India, the disease has been linked to consumption ...
Update: Outbreak of Nipah Virus - | Nipah virus Singapore
No new cases of febrile illness associated with Nipah virus infection have been identified in Singapore since March 19, 1999, when abattoirs ...
Nipah virus could cause the next major epidemic | Nipah virus Singapore
Singapore banned the import of all live pigs from Malaysia from 1999 to 2017 due to the previous Nipah outbreak Experts are warning of the ...
Risk Factors for Nipah Virus Infection among Abattoir Workers ... | Nipah virus Singapore
Discussion. The Nipah virus outbreak in Singapore was associated with importation and slaughter of infected pigs from Malaysia. Evidence for a causal ...
Singapore Conference Explored Global Threat of Nipah Virus ... | Nipah virus Singapore
Nipah virus was first identified in 1999 following a large outbreak affecting Malaysia and Singapore. The virus is one of eight categories of ...
Lessons to be learnt from the Nipah virus outbreak in Singapore | Nipah virus Singapore
MeSH terms. Abattoirs; Animals; Centers for Disease Control and Prevention, U.S.; Diagnosis, Differential; Disease Outbreaks*; Encephalitis, Viral / diagnosis ...
Outbreak of Nipah-virus infection among abattoir workers in ... | Nipah virus Singapore
Abstract. Background: In March 1999, an outbreak of encephalitis and pneumonia occurred in workers at an abattoir in Singapore. We describe the clinical ...
Foodborne Transmission of Nipah Virus, Bangladesh | Nipah virus Singapore
A single dose investigational subunit vaccine for human use against ... | Nipah virus Singapore
Nipah Virus (NiV) | Nipah virus Singapore
Nipah virus infection | Nipah virus Singapore
Nipah | Nipah virus Singapore
No new cases reported in Singapore or Malaysia since then. Further outbreaks of Nipah virus infection have occurred elsewhere, mainly in western Bangladesh ...