Chlamydia pneumoniae is an obligate intracellular bacterial pathogen that infects the respiratory tract. The majority of individuals are exposed to C.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListHHSAuthorManuscriptsPMC6345537ForImmunopatholDisTherap.Authormanuscript;availableinPMC2019Jan24.Publishedinfinaleditedformas:ForImmunopatholDisTherap.2016;7(3-4):237–254.doi: 10.1615/ForumImmunDisTher.2017020161PMCID:PMC6345537NIHMSID:NIHMS1007353PMID:30687565ChlamydiapneumoniaeInfectionandInflammatoryDiseasesRebeccaA.PorrittandTimothyR.Crother*AuthorinformationCopyrightandLicenseinformationDisclaimerDivisionofPediatricInfectiousDiseasesandImmunology,BurnsandAllenResearchInstitute,Cedars-SinaiMedicalCenter,LosAngeles,CA90048*Addressallcorrespondenceto:TimothyR.Crother,Ph.D.;AssistantProfessorofPediatrics,DivisionofPediatricInfectiousDiseasesandImmunology,Cedars-SinaiMedicalCenter,8700BeverlyBlvd.,Room4221,LosAngeles,CA90048;Tel.:(310)423-7970;Fax:(310)423-8284,gro.shsc@rehtorc.yhtomitCopyrightnoticeSeeotherarticlesinPMCthatcitethepublishedarticle.Chlamydiapneumoniae,anobligateintracellularbacterialpathogen,haslongbeeninvestigatedasapotentialdevelopmentalorexacerbatingfactorinvariouspathologies.Itsuniquelifestyleandabilitytodisseminatethroughoutthehostwhilepersistinginrelativesafetyfromtheimmuneresponsehasplacedthisobligateintracellularpathogeninthecrosshairsasapotentiallymitigatingfactorinchronicinflammatorydiseases.ManyanimalmodelandhumancorrelativestudieshavebeenperformedtoconfirmordenyaroleforC.pneumoniaeinfectioninthesedisorders.Insomecases,antibioticclinicaltrialswereconductedtoprovealinkbetweenbacterialinfectionsandatherosclerosis.Inthisreview,wedetailthelatestinformationregardingthepotentialrolethatC.pneumoniaeinfectionmayhaveinchronicinflammatorydiseases.Keywords:Alzheimer’s,arthritis,asthma,atherosclerosis,cancer,ChlamydiapneumoniaeChlamydiapneumoniaeisanobligat