Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, ...March-April2017-Volume6-Issue2PreviousArticleNextArticleArticleasEPUBExportAllImagestoPowerPointFileAddtoMyFavoritesColleague'sE-mailisInvalidYourName:(optional)YourEmail:Colleague'sEmail:Separatemultiplee-mailswitha(;).Message:Thoughtyoumightappreciatethisitem(s)IsawatTheAsia-PacificJournalofOphthalmology.SendacopytoyouremailYourmessagehasbeensuccessfullysenttoyourcolleague.Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime.EndNoteProciteReferenceManagerSavemyselectionReviewArticleuSilverman,NoraMD,PhD;Shinder,RomanMD,FACSAuthorInformationFromtheDepartmentofOphthalmology,SUNYDownstateMedicalCenter,Brooklyn,NY.ReceivedforpublicationJanuary4,2017;acceptedFebruary3,2017.SupportedbyResearchtoPreventBlindness.Theauthorshavenootherfundingorconflictsofinteresttodeclare.Reprints:RomanShinder,MD,FACS,DepartmentofOphthalmology,SUNYDownstateMedicalCenter,541ClarksonAve,EBldg,8thFl,SuiteC,Brooklyn,NY11203.E-mail:[email protected].Asia-PacificJournalofOphthalmology:March2017-Volume6-Issue2-p143-152doi:10.22608/APO.201701FreeMetricsAbstractEyelidmalignanciesrepresentbetween5%and10%ofallskincancers.Basalcellcarcinomaisthemostcommon,followedbysquamouscellcarcinoma,sebaceouscellcarcinoma,Merkelcellcarcinoma,andmelanoma.Thegoldstandardtreatmentforperiocularepithelialmalignanciesissurgicalexcision.Giventheconstraintsoftheanatomyandfunctionoftheeyelids,excisionwithnegativemarginsandreconstructioncanbechallenging.Incasesofsignificanttissueinvasionormetastasis,completetumorremovalmaynotbepossible.Thisreviewexaminesthemanagementofperiocularskincancerfromdiagnosisandstaging,includingtheroleofsentinellymphnodebiopsy,tobothsurgicalandnonsurgicaltreatment.Thedevelopmentoftargeteddrugtherapyagainstspecificgeneticmutationsincutaneousmalignancieshasallowedforthetreatmentofspecificcancercellswithlesssystemictoxicitythanmoretradi