The hamartomatous polyposis syndromes are a fascinating group of disorders which have in common relatively benign appearing polyps of the GI tract, but also ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListHHSAuthorManuscriptsPMC2659506SurgClinNorthAm.Authormanuscript;availableinPMC2009Aug1.Publishedinfinaleditedformas:SurgClinNorthAm.2008Aug;88(4):779–vii.doi: 10.1016/j.suc.2008.05.002PMCID:PMC2659506NIHMSID:NIHMS67434PMID:18672141HAMARTOMATOUSPOLYPOSISSYNDROMESDanielCalva,M.D.1andJamesR.Howe,M.D.2DanielCalva1ResidentinSurgery,RoyJ.andLucilleA.CarverUniversityofIowaCollegeofMedicine,IowaCity,IAFindarticlesbyDanielCalvaJamesR.Howe2ProfessorofSurgery,Chief,DivisionofSurgicalOncologyandEndocrineSurgery,RoyJ.andLucilleA.CarverUniversityofIowaCollegeofMedicine;IowaCity,IAFindarticlesbyJamesR.HoweAuthorinformationCopyrightandLicenseinformationDisclaimer1ResidentinSurgery,RoyJ.andLucilleA.CarverUniversityofIowaCollegeofMedicine,IowaCity,IA2ProfessorofSurgery,Chief,DivisionofSurgicalOncologyandEndocrineSurgery,RoyJ.andLucilleA.CarverUniversityofIowaCollegeofMedicine;IowaCity,IAAddresscorrespondesto:JamesR.Howe,M.D.,DepartmentofSurgery,UniversityofIowaHospitalsandClinics,200HawkinsDrive,IowaCity,IA,52242-1086,Tel.(319)356-1727,Fax.(319)356-1218,E-mail:ude.awoiu@ewoh-semajCopyrightnoticePublisher'sDisclaimerThepublisher'sfinaleditedversionofthisarticleisavailableatSurgClinNorthAmSeeotherarticlesinPMCthatcitethepublishedarticle.Sincethehistologicaldescriptionofthehamartomatouspolypin1957byHorrillenoetal.,severaldifferentsyndromeshavebeendescribedwiththepropensitytodevelopthesepolypsintheupperandlowerGItracts.TheseincludeJuvenilePolyposis,Peutz-Jegherssyndrome,hereditarymixedpolyposissyndrome,andthePTENhamartomatumorsyndromes(CowdenandBannayan-Riley-Ruvalcabasyndromes),whichareautosomal-dominantlyinherited,andCronkhite-Canadasyndrome,whichisacquired.Theclinicalaspects,themolecularpathogenesis,theorgansystemsaffected,t