Somatostatin is produced by neuroendocrine neurons of the ventromedial nucleus of the hypothalamus. These neurons project to the median eminence, where ...SomatostatinFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchNottobeconfusedwithSomatocrininorSomatomedin.SSTAvailablestructuresPDBOrthologsearch:PDBeRCSBListofPDBidcodes2MI1IdentifiersAliasesSST,SMST,somatostatin,Somatostatin,Somatostatin,SST1ExternalIDsOMIM:182450MGI:98326HomoloGene:819GeneCards:SSTGenelocation(Human)Chr.Chromosome3(human)[1]Band3q27.3Start187,668,912bp[1]End187,670,394bp[1]Genelocation(Mouse)Chr.Chromosome16(mouse)[2]Band16B1|1615.0cMStart23,889,573bp[2]End23,890,958bp[2]RNAexpressionpatternMorereferenceexpressiondataGeneontologyMolecularfunction•hormoneactivityCellularcomponent•extracellularregion•neuronalcellbody•extracellularBiologicalprocess•negativeregulationofcellproliferation•hormone-mediatedapoptoticsignalingpathway•hyperosmoticresponse•chemicalsynaptictransmission•regulationofcellmigration•responsetoheat•responsetonutrient•responsetoacidicpH•responsetodrug•responsetosteroidhormone•G-proteincoupledreceptorsignalingpathway•responsetoaminoacid•cell-cellsignaling•responsetoorganonitrogencompound•digestion•cellsurfacereceptorsignalingpathway•regulationofreceptoractivitySources:Amigo/QuickGOOrthologsSpeciesHumanMouseEntrez675020604EnsemblENSG00000157005ENSMUSG00000004366UniProtP61278P60041RefSeq(mRNA)NM_001048NM_009215RefSeq(protein)NP_001039NP_033241Location(UCSC)Chr3:187.67–187.67MbChr16:23.89–23.89MbPubMedsearch[3][4]WikidataView/EditHumanView/EditMouseSomatostatin,alsoknownasgrowthhormone-inhibitinghormone(GHIH)orbyseveralothernames,isapeptidehormonethatregulatestheendocrinesystemandaffectsneurotransmissionandcellproliferationviainteractionwithGprotein-coupledsomatostatinreceptorsandinhibitionofthereleaseofnumeroussecondaryhormones.Somatostatininhibitsinsulinandglucagonsecretion.[5]Somatostatinhastwoactiveformsproducedbythealternativecleavageofasinglepreproprotein:oneconsisti