Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the ...BreastcancerFromWikipedia,thefreeencyclopediaThisisthelatestacceptedrevision,reviewedon9August2021.JumptonavigationJumptosearchCancerthatoriginatesinthemammaryglandMedicalconditionBreastcancerAnillustrationofbreastcancerSpecialtyOncologySymptomsAlumpinabreast,achangeinbreastshape,dimplingoftheskin,fluidfromthenipple,anewlyinvertednipple,aredscalypatchofskinonthebreast[1]RiskfactorsBeingfemale,obesity,lackofexercise,alcohol,hormonereplacementtherapyduringmenopause,ionizingradiation,earlyageatfirstmenstruation,havingchildrenlateinlifeornotatall,olderage,priorbreastcancer,familyhistoryofbreastcancer,Klinefeltersyndrome[1][2][3]DiagnosticmethodTissuebiopsy[1]MammographyTreatmentSurgery,radiationtherapy,chemotherapy,hormonaltherapy,targetedtherapy[1]PrognosisFive-yearsurvivalrate≈85%(US,UK)[4][5]Frequency2.1 millionaffectedasof2018[6]Deaths627,000(2018)[6]Breastcanceriscancerthatdevelopsfrombreasttissue.[7]Signsofbreastcancermayincludealumpinthebreast,achangeinbreastshape,dimplingoftheskin,fluidcomingfromthenipple,anewlyinvertednipple,oraredorscalypatchofskin.[1]Inthosewithdistantspreadofthedisease,theremaybebonepain,swollenlymphnodes,shortnessofbreath,oryellowskin.[8]Riskfactorsfordevelopingbreastcancerincludebeingfemale,obesity,alackofphysicalexercise,alcoholism,hormonereplacementtherapyduringmenopause,ionizingradiation,anearlyageatfirstmenstruation,havingchildrenlateinlifeornotatall,olderage,havingapriorhistoryofbreastcancer,andafamilyhistoryofbreastcancer.[1][2]About5–10%ofcasesaretheresultofageneticpredispositioninheritedfromaperson'sparents,[1]includingBRCA1andBRCA2amongothers.[1]Breastcancermostcommonlydevelopsincellsfromtheliningofmilkductsandthelobulesthatsupplytheseductswithmilk.[1]Cancersdevelopingfromtheductsareknownasductalcarcinomas,whilethosedevelopingfromlobulesareknownaslobularcarcinomas.[1]Therea