Role of DEAD-Box RNA Helicase 3 (DDX3) in Viral Replication. A series of large-scale ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListPathogensv.8(1);2019MarPMC6470645Pathogens.2019Mar;8(1):17.Publishedonline2019Jan29.doi: 10.3390/pathogens8010017PMCID:PMC6470645PMID:30699976Virus–HostInteractionsInvolvedinLassaVirusEntryandGenomeReplicationMaríaEugeniaLoureiro,*AlejandraD’Antuono,andNoraLópezAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerCentrodeVirologíaAnimal(CEVAN),CONICET-SENASA,AvSirAlexanderFleming1653,Martínez,ProvinciadeBuenosAiresB1640CSI,Argentina;moc.liamg@onoutnada(A.D.);moc.liamg@rapolmaron(N.L.)*Correspondence:ra.moc.oohay@orieruolainegue;Tel.:+54-11-4105-4100Received2018Dec21;Accepted2019Jan26.Copyright©2019bytheauthors.LicenseeMDPI,Basel,Switzerland.ThisarticleisanopenaccessarticledistributedunderthetermsandconditionsoftheCreativeCommonsAttribution(CCBY)license(http://creativecommons.org/licenses/by/4.0/).ThisarticlehasbeencitedbyotherarticlesinPMC.Lassavirus(LASV)isthecausativeagentofLassafever,ahumanhemorrhagicdiseaseassociatedwithhighmortalityandmorbidityrates,particularlyprevalentinWestAfrica.Overthepastfewyears,asignificantamountofnovelinformationhasbeenprovidedoncellularfactorsthataredeterminantelementsplayingaroleinarenavirusmultiplication.Inthisreview,wefocusonhostproteinsthatintersectwiththeinitialstepsoftheLASVreplicationcycle:virusentryandgenomereplication.Abetterunderstandingofrelevantvirus–hostinteractionsessentialforsustainingthesecriticalstepsmayhelptoidentifypossibletargetsfortherationaldesignofnoveltherapeuticapproachesagainstLASVandotherarenavirusesthatcauseseverehumandisease.Keywords:Lassafever,arenavirus,LASV,virus–hostinteractions,entry,replicationTheArenaviridaefamilyincludesvirusescarriedbymammalianhosts,classifiedintheMammarenavirusgenus,andmembersthatinfectreptilianhosts,whichbelongtotheReptarenavirusandHartmanivirusgenera[1].Mammarenavirusesco