Mechanisms of Hypersensitivity | Hypersensitivity reaction
NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListNaturePublicHealthEmergencyCollectionPMC7120502DrugAllergy.2013May3:37–90.Publishedonline2013May3.doi: 10.1007/978-1-4614-7261-2_3PMCID:PMC7120502MechanismsofHypersensitivityBrianA.Baldo00031andNghiaH.Pham00031BrianA.BaldoFormerly-MolecularImmunologyUnitKollingInstituteofMedicalResearch,RoyalNorthShoreHospitalofSydney,Sydney,AustraliaFindarticlesbyBrianA.BaldoNghiaH.PhamFormerly-MolecularImmunologyUnitKollingInstituteofMedicalResearch,RoyalNorthShoreHospitalofSydney,Sydney,AustraliaFindarticlesbyNghiaH.PhamAuthorinformationCopyrightandLicenseinformationDisclaimerFormerly-MolecularImmunologyUnitKollingInstituteofMedicalResearch,RoyalNorthShoreHospitalofSydney,Sydney,AustraliaCorrespondingauthor.Copyright©SpringerScience+BusinessMedia,LLC2013ThisarticleismadeavailableviathePMCOpenAccessSubsetforunrestrictedresearchre-useandsecondaryanalysisinanyformorbyanymeanswithacknowledgementoftheoriginalsource.ThesepermissionsaregrantedforthedurationoftheWorldHealthOrganization(WHO)declarationofCOVID-19asaglobalpandemic.Allergicreactionstodrugsarenotalwaystheresultofthedrug’sprotein-bindingcapacity,biotransformation,ordegradation.Mediatorreleasemayoccurviacross-linkingofcell-boundIgEbydi-(multi-)valentfreedrug.Physiologicalandpharmacologicaleffectsofhistaminearemediatedthroughfourreceptors,H1,H2,H3,andH4.TheH3receptorhasaregulatoryroleinthereleaseofneurotransmitterssuchasserotoninanddopamine;theH4receptorexertsachemotacticeffectonseveralcelltypesassociatedwithallergyandasthma.CysteinylleukotrienesandPAFarepowerfulmediatorsofanaphylaxis,asthma,andshock.Sphingosine-1-phosphate,elevatedinthelungsofasthmatics,regulatespulmonaryepitheliumpermeabilityandcontributestothepathogenesisofanaphylaxis.Urticariaisaheterogeneousdiseasewithmanysubtypes.BothACEinhibitorsandangiotensinIIreceptorblockersmaycauseangioedema.Abacavirchangestheshapeofthe
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HypersensitivityImmediate hypersensitivity reactionType 1 hypersensitivityType 2 hypersensitivityhypersensitivity中文hypersensitivity reaction中文Gell and Coombs classificationType 4 hypersensitivity