NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermMononucleosisMichaelMohseni;MichaelP.Boniface;CharlesGraham.AuthorInformationAuthorsMichaelMohseni1;MichaelP.Boniface2;CharlesGraham3.Affiliations1MayoClinic2MayoClinic3MayoClinicFloridaLastUpdate:November21,2020.ContinuingEducationActivityMononucleosisclassicallypresentswithfever,lymphadenopathy,andtonsillarpharyngitis.Theterminfectiousmononucleosiswasfirstusedinthe1920stodescribeagroupofstudentswithasimilarpharyngealillnessandbloodlaboratoryfindingsoflymphocytosisandatypicalmononuclearcells.ItwasonlylaterthattheEpstein-Barrvirus(EBV)wasestablishedasthecauseofmononucleosisafteranexposedhealthcareworkerdevelopedapositiveheterophiletest.Thisactivityreviewsthecause,pathophysiology,andpresentationofmononucleosisandhighlightstheroleoftheinterprofessionalteaminitsmanagement.Objectives:Describethepathophysiologyofmononucleosis.Reviewthepresentationofmononucleosis.Summarizethetreatmentofmononucleosis.Outlinetheimportanceofimprovingcarecoordinationamonginterprofessionalteammemberstoimproveoutcomesforpatientsaffectedbymononucleosis.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionMononucleosisclassicallypresentswithfever,lymphadenopathy,andtonsillarpharyngitis.Theterm“infectiousmononucleosis”wasfirstusedinthe1920stodescribeagroupofstudentswithasimilarpharyngealillnessandbloodlaboratoryfindingsoflymphocytosisandatypicalmononuclearcells.ItwasonlylaterthatEpstein-Barrvirus(EBV)wasestablishedasthecauseofmononucleosisafteranexposedhealthcareworkerdevelopedapositiveheterophiletest.[1][2]EtiologyThecauseofmononucleosisistheEpstein-Barrvirus(EBV).EBVisatypeof herpesvirusspreadbycontact,typicallywithsalivarysecretions.Thedurationoforalsheddi