According to revised Jones criteria, the diagnosis of rheumatic fever can be made when two of the major criteria, or one major criterion ...RheumaticfeverFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchPost-streptococcalinflammatorydiseaseMedicalconditionRheumaticfeverOthernamesAcuterheumaticfever(ARF)Rheumaticheartdiseaseatautopsywithcharacteristicfindings(thickenedmitralvalve,thickenedchordaetendineae,hypertrophiedleftventricularmyocardium).SpecialtyCardiologySymptomsFever,multiplepainfuljoints,involuntarymusclemovements,erythemamarginatum[1]ComplicationsRheumaticheartdisease,heartfailure,atrialfibrillation,infectionofthevalves[1]Usualonset2–4weeksafterastreptococcalthroatinfection,age5-14years[2]CausesAutoimmunediseasetriggeredbyStreptococcuspyogenes[1]RiskfactorsGenetics,malnutrition,poverty[1]DiagnosticmethodBasedonsymptomsandinfectionhistory[3]PreventionAntibioticsforstrepthroat,improvedsanitation[1][4]TreatmentProlongedperiodsofantibiotics,valvereplacementsurgery,valverepair[1]Frequency325,000childrenayear[1]Deaths319,400(2015)[5]Rheumaticfever(RF)isaninflammatorydiseasethatcaninvolvetheheart,joints,skin,andbrain.[1]Thediseasetypicallydevelopstwotofourweeksafterastreptococcalthroatinfection.[2]Signsandsymptomsincludefever,multiplepainfuljoints,involuntarymusclemovements,andoccasionallyacharacteristicnon-itchyrashknownaserythemamarginatum.[1]Theheartisinvolvedinabouthalfofthecases.[1]Damagetotheheartvalves,knownasrheumaticheartdisease(RHD),usuallyoccursafterrepeatedattacksbutcansometimesoccurafterone.[1]Thedamagedvalvesmayresultinheartfailure,atrialfibrillationandinfectionofthevalves.[1]RheumaticfevermayoccurfollowinganinfectionofthethroatbythebacteriumStreptococcuspyogenes.[1]Iftheinfectionisleftuntreated,rheumaticfeveroccursinuptothreepercentofpeople.[6]Theunderlyingmechanismisbelievedtoinvolvetheproductionofantibodiesagainstaperson'sowntissues.[1]Duetotheirgenetics,somepeoplearemorelikelytogetthediseasewhenexposedtothebacteriathanothers.[1]Othe