Type IV Hypersensitivity Reaction | Gell and Coombs classification
NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermTypeIVHypersensitivityReactionKhaledMarwa;NoahP.Kondamudi.AuthorInformationAuthorsKhaledMarwa1;NoahP.Kondamudi2.Affiliations1Universityofscienceandtechnology-Yemen2IcahnSchoolofMedicineatMountSinai,TheBrooklynHospitalCenterLastUpdate:April26,2021.ContinuingEducationActivityTypefourhypersensitivityreactionisacell-mediatedreactionthatcanoccurinresponsetocontactwithcertainallergensresultinginwhatiscalledcontactdermatitisorinresponsetosomediagnosticproceduresasinthetuberculinskintest.Certainallergensmustbeavoidedtotreatthiscondition.Thisactivityreviewstheevaluationandmanagementoftypefourhypersensitivityreactionsandhighlightstheroleoftheinterprofessionalteaminimprovingcareforpatientswiththiscondition.Objectives:Describetheepidemiologyoftypefourhypersensitivityreactions.Summarizethepathophysiologyoftypefourhypersensitivityreactions.Explainthecommonphysicalexamfindingsassociatedwithtypefourhypersensitivityreactions.Reviewtheimportanceofcollaborationandcarecoordinationamongsttheinterprofessionalteamtoenhancethecareofpatientswithtypefourhypersensitivityreactions.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionOurimmunesystemplaysacrucialroleinprotectingourbodyagainstpathogens,butsometimesthereisanexaggeratedresponse.Thisexaggeratedresponseistriggeredbytheinteractionoftheimmunesystemwithanantigen(allergen)andisreferredtoashypersensitivity.HypersensitivityreactionsareclassifiedintofourtypesbyCoombsandGell. Thefirstthreetypesareconsideredimmediatehypersensitivityreactionsbecausetheyoccurwithin24hours. Thefourthtypeisconsideredadelayedhypersensitivityreactionbecauseitusuallyoccursmorethan12hoursafterexposuretotheallergen,withamaximalre
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