Twin to twin transfusion syndrome (TTTS) occurs in 10 to 15% of monochorionic twin gestations. The pathophysiology of TTTS is intertwin blood ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturescientificreportsarticlesarticleEarlypostnatalcardiacmanifestationsareassociatedwithperinatalbraininjuryinpreterminfantswithtwintotwintransfusionsyndromeDownloadPDFSubjectsCardiovasculardiseasesNeurologicaldisordersPaediatricresearchAbstractAlteredhemodynamicsassociatedwithtwintotwintransfusionsyndrome(TTTS)canbemanifestedinthefetalandneonatalheart.ThisstudyevaluatedtheassociationbetweencardiacmanifestationsimmediatelyafterbirthandbraininjuryinpreterminfantswithTTTS.Medicalrecordsofpreterminfantswhowerebornat<35weeksofgestationwithTTTSandadmittedtotheneonatalintensivecareunitatSeoulNationalUniversityChildren’sHospitalbetweenJanuary2011andJanuary2018werereviewed.TTTSwasprenatallydiagnosedandstagedaccordingtotheQuinterocriteria.Echocardiographicfindings,brainultrasoundandMRIimagingfindingswereanalyzed.Fifty-threeinfantswereenrolledinthisstudy.Thirty-twoinfants(60.3%)weretreatedbyfetoscopiclasercoagulation.Braininjurydevelopedin15infants(28.3%).Hypotensionwithinthefirstweekandimmediatepostnatalcardiacmanifestationsweremoreprevalentinthebraininjurygroup.Inthemultivariateanalysis,acutekidneyinjuryandcardiacmanifestations,suchasventriculardysfunctionandtricuspidregurgitation,werestatisticallyassociatedwithbraininjuryinthestudypopulation.Immediatepostnatalcardiacmanifestations,suchasventriculardysfunctionandtricuspidregurgitation,canserveassurrogatemarkersforperinatalhemodynamicdisturbance,whichareassociatedwithearlyneonatalbraininjuryinpreterminfantswithTTTS.DownloadPDFIntroductionTwintotwintransfusionsyndrome(TTTS)occur