Targeting Kinases in Fasciola hepatica: Anthelminthic Effects and Tissue Distribution of Selected Kinase Inhibitors.ThisarticleispartoftheResearchTopicTrematodeInfectioninRuminantsViewall7ArticlesArticlesKhalidMehmoodFacultyofVeterinaryandAnimalSciences,IslamiaUniversityofBahawalpur,PakistanAaronMauleQueen'sUniversityBelfast,UnitedKingdomPaulMcVeighQueen'sUniversityBelfast,UnitedKingdomTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionMaterialsandMethodsResultsDiscussionDataAvailabilityStatementEthicsStatementAuthorContributionsFundingConflictofInterestAcknowledgmentsSupplementaryMaterialReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataORIGINALRESEARCHarticleFront.Vet.Sci.,21December2020|https://doi.org/10.3389/fvets.2020.611270TargetingKinasesinFasciolahepatica:AnthelminthicEffectsandTissueDistributionofSelectedKinaseInhibitorsCarolinM.Morawietz1,HichamHouhou2,OliverPuckelwaldt2,LauraHehr3,DomenicDreisbach1,AnnikaMokosch1,ElkeRoeb3,MartinRoderfeld3,BernhardSpengler1†andSimoneHaeberlein2*†1InstituteofInorganicandAnalyticalChemistry,JustusLiebigUniversityGiessen,Giessen,Germany2BiomedicalResearchCenterSeltersberg(BFS),InstituteofParasitology,JustusLiebigUniversityGiessen,Giessen,Germany3DepartmentofGastroenterology,JustusLiebigUniversityGiessen,Giessen,GermanyProteinkinaseshavebeendiscussedaspromisingdruggabletargetsinvariousparasitichelminths.Newdrugsarealsoneededforcontroloffascioliasis,afood-bornetrematodeinfectionandworldwidespreadzoonosis,causedbytheliverflukeFasciolahepaticaandrelatedspecies.Inthisstudy,weintendedtomoveproteinkinasesmoreintothespotlightofFascioladrugresearchandcharacterizedthefasciolicidalactivityoftwosmall-moleculeinhibitorsfromhumancancerresearch:theAbelsontyrosinek