Peripheral T-Cell Lymphomas: Diagnosis and Treatment ... | peripheral t-cell lymphoma

In the United States, there are approximately 66,000 new cases of non-Hodgkin lymphoma each year8; peripheral T-cell lymphoma (PTCL) represents approximately 10 ...Volume9,Issue11,Supplement26 November2011PeripheralT-CellLymphomas:DiagnosisandTreatmentOptionsProceedingsFromaLiveRoundtable,August17,2011,Kauai,HawaiiModeratorBruceD.Cheson,MDDeputyChiefDivisionofHematology-OncologyHeadofHematologyLombardiComprehensiveCancerCenterGeorgetownUniversityHospitalWashington,DCDiscussantsStevenM.Horwitz,MDMedicalOncologistMemorialSloan-KetteringCancerCenterNewYork,NewYorkDennisD.Weisenburger,MDDirector,HematopathologyUniversityofNebraskaMedicalCenterOmaha,NebraskaACMEActivity Approvedfor 1.25AMAPRA Category1Credit(s)-TMReleaseDate: November2011ExpirationDate: November30,2012Estimatedtimetocompleteactivity: 1.25hoursProjectID: 8400Abstract: PeripheralT-celllymphomasareacollectionofrarediseases,mostofwhichhaveapoorprognosis.Thebasiccategoriesincludeprecursorlymphoidneoplasms(eg,lymphoblasticlymphoma);maturenaturalkiller/T-cellneoplasmsandextranodallymphomas,includingenteropathy-associatedT-celllymphoma;hepatosplenicT-celllymphoma;andsubcutaneouspanniculitis-likeT-celllymphoma.Themostcommonvarietiesarethenodaltypes,whichincludeperipheralT-celllymphomanototherwisespecified,anaplasticlargecelllymphomas,andangioimmunoblasticT-celllymphomas.Eachofthesubtypeshascharacteristicclinicalmanifestations.Thefrequenciesofthesubtypesvarybygeographicregion.Thediagnosiscanbedifficult,andtheWorldHealthOrganizationclassificationsystemwasrecentlyevaluatedtoassessitsclinicalapplicabilityandreproducibilityforperipheralT-celllymphomasandnaturalkiller/T-celllymphomas.Atleast10%ofpatientsareincorrectlydiagnosedbylocallaboratories,andmanysubtypesneedbetterdiagnosticmarkersandcriteria.Currently,anincreasingnumberofeffectiveandtolerabletherapiesarebecomingavailable,includingpralatrexate,brentuximabvedotin,romidepsin,andbendamustine.Accuratediagnosisisnecessarytoallowappropriatetreatment,asexemplifiedbypat

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