Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest and can interfere with your daily ...COVID-19:Advice,updatesandvaccineoptionsWeareopenforsafein-personcare.Learnmore:MayoClinicfactsaboutcoronavirusdisease2019(COVID-19)OurCOVID-19patientandvisitorguidelines,plustrustedhealthinformationLateston COVID-19vaccination bysite:ArizonapatientvaccinationupdatesArizona,FloridapatientvaccinationupdatesFlorida,RochesterpatientvaccinationupdatesRochesterandMayoClinicHealthSystempatientvaccinationupdatesMCHSSkiptositenavigationSkiptoContentThiscontentdoesnothaveanEnglishversion.ThiscontentdoesnothaveanArabicversion.SectionsforDepression(majordepressivedisorder)Symptoms&causesDiagnosis&treatmentDoctors&departmentsCareatMayoClinicPrintOverviewDepressionisamooddisorderthatcausesapersistentfeelingofsadnessandlossofinterest.Alsocalledmajordepressivedisorderorclinicaldepression,itaffectshowyoufeel,thinkandbehaveandcanleadtoavarietyofemotionalandphysicalproblems.Youmayhavetroubledoingnormalday-to-dayactivities,andsometimesyoumayfeelasiflifeisn'tworthliving.Morethanjustaboutoftheblues,depressionisn'taweaknessandyoucan'tsimply"snapout"ofit.Depressionmayrequirelong-termtreatment.Butdon'tgetdiscouraged.Mostpeoplewithdepressionfeelbetterwithmedication,psychotherapyorboth.DepressioncareatMayoClinicProducts&ServicesBook:MayoClinicFamilyHealthBook,5thEditionNewsletter:MayoClinicHealthLetter—DigitalEditionShowmoreproductsfromMayoClinicSymptomsAlthoughdepressionmayoccuronlyonceduringyourlife,peopletypicallyhavemultipleepisodes.Duringtheseepisodes,symptomsoccurmostoftheday,nearlyeverydayandmayinclude:Feelingsofsadness,tearfulness,emptinessorhopelessnessAngryoutbursts,irritabilityorfrustration,evenoversmallmattersLossofinterestorpleasureinmostorallnormalactivities,suchassex,hobbiesorsportsSleepdisturbances,includinginsomniaorsleepingtoomuchTirednessandlackofenergy,soevensmalltaskstakeextraeffortReducedappetiteandweightlossorincreasedcravingsforfoodandwei