Effect of vaccination on feline Chlamydia psittaci infection. | chlamydia vaccine for cats
Subcutaneous vaccination with live feline pneumonitis C. psittaci 4 weeks before ocular challenge significantly reduced the severity of the conjunctivitis.NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListInfectImmunv.55(11);1987NovPMC259956InfectImmun.1987Nov;55(11):2653–2657.PMCID:PMC259956PMID:3666957EffectofvaccinationonfelineChlamydiapsittaciinfection.JMWills,TJGruffydd-Jones,SJRichmond,RMGaskell,andFJBourneAuthorinformationCopyrightandLicenseinformationDisclaimerDepartmentofVeterinaryMedicine,UniversityofBristol,Langford,England.CopyrightnoticeThisarticlehasbeencitedbyotherarticlesinPMC.AbstractExperimentalocularinfectionofspecific-pathogen-freecatswiththefelinepneumonitisstrainofChlamydiapsittaciproducedanacute,severeconjunctivitischaracterizedbyblepharospasm,conjunctivalhyperemia,chemosis,andoculardischarge.Organismswererecoveredfromtheconjunctivaforseveralweeks,andpersistentgenitalandgastrointestinalinfectionalsoresultedfromtheocularinfectioninsomecats.SubcutaneousvaccinationwithlivefelinepneumonitisC.psittaci4weeksbeforeocularchallengesignificantlyreducedtheseverityoftheconjunctivitis.However,therewasnoeffectonsheddingoforganismsfromtheeyeoronthetransmissionofinfectiontothegastrointestinalandgenitaltracts.Itissuggestedthattheacutestageofthisoculardiseaseiscausedlargelybyreleaseofpathogenicantigen(s)fromchlamydia-infectedconjunctivalcells,ratherthanbyadirectcytopathiceffectofchlamydialreplication.Thus,vaccinationwithwholeliveorganismsreducedtheacutediseaseinexperimentallyinfectedcatsbutdidnotpreventsheddingoftheorganism.Theimplicationsofthesefindingsarediscussed.FulltextFulltextisavailableasascannedcopyoftheoriginalprintversion.Getaprintablecopy(PDFfile)ofthecompletearticle(850K),orclickonapageimagebelowtobrowsepagebypage.LinkstoPubMedarealsoavailableforSelectedReferences. 26532654265526562657 SelectedReferencesThesereferencesareinPubMed.Thismaynotbethecompl
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