Juvenile polyposis syndrome (JPS) is a genetic disorder in which growths, called polyps, are found on the lining of the the gastrointestinal (GI) ...CORONAVIRUS:DELAYSFORROUTINESURGERIES,VISITORRESTRICTIONS+COVID-19TESTING.Home/HealthLibrary/Disease&ConditionsJuvenilePolyposisSyndrome(JPS)Juvenilepolyposissyndrome(JPS)isageneticdisorderinwhichgrowths,calledpolyps,arefoundontheliningofthethegastrointestinal(GI)tract.Theconditionaffectsabout1in100,000to1in160,000people.Appointments&AccessContactUsJuvenilePolyposisSyndrome(JPS)MenuOverviewDiagnosisandTestsManagementandTreatmentPreventionOutlook/PrognosisLivingWithResourcesWhatisjuvenilepolyposissyndrome(JPS)?Juvenilepolyposissyndrome(JPS)isadisordermarkedbygrowths,calledpolyps,whichgrowontheliningofthegastrointestinal(GI)tract.ThesepolypscanoccuranywhereintheGItract,fromthestomachtotherectum.InJPS,theword“juvenile”referstothewaythepolypslookunderthemicroscope,andnottotheageofthepeoplewhogetthedisorder.However,mostpeopledevelopsymptomsofJPSbythetimetheyare20yearsold.ThepolypsinJPSmostoftengrowinthelargeintestine(colon)andrectum,butcanalsogrowinthestomachand,morerarely,thesmallintestine.ApersonwithJPScanhaveafewpolypsormorethanahundred.Thepolypscanvaryinshapeandsize.Theymaybeflatoronastalk.Howcommonisjuvenilepolyposissyndrome(JPS)?JPSisestimatedtoaffectanywherefrom1in100,000to1in160,000people.Whatcausesjuvenilepolyposissyndrome(JPS)?JPSisageneticdisorder,whichmeansitiscausedwhensomethingiswrongwithagenethattellsyourGItracthowtodevelop.Aproblemordefectinthegenefunctioncandisruptcellgrowthanddeathandthewaygenesworktogether.ThiscancausethenormaltissueoftheGItracttogrowinanuncontrolledway,whichcanleadtopolypsforming.MostcasesofJPSarecausedbyagenechange(mutation)thatispasseddownfromoneoftheparentstothebaby.About75%ofpeoplewithJPShaveafamilyhistoryofthedisorder.Ifoneofyourparentshasagenewiththedefect,youandyourbrothersandsistershavea50%chanceofinheritingJPS.About25%ofthetime,thegenedoesnotgetinheritedbutoccursatthetimeofformat