The primary difference between these two categories of lymphatic cancer is the type of lymphocyte that is affected. Hodgkin lymphoma is marked by the presence​ ...COVID-19SafetyPrecautions:FindtheLatestVisitorandMaskPolicies. LearnMoreHomeCancersLymphomas(HodgkinandNon-Hodgkin)FAQsHodgkinLymphomavs.Non-HodgkinLymphomaPageMenuHodgkinLymphomavs.Non-HodgkinLymphomaDifferencesBetweenHodgkin&Non-HodgkinLymphomaFacebookTwitterLinkedinPinterestEmailWithtwosimilar-soundingnames,Hodgkinlymphomaandnon-Hodgkinlymphomacaneasilybeconfused.Lymphomaisaformofcancerthataffectsthelymphocytes,atypeofwhitebloodcellthatplaysanimportantroleintheimmunesystem.Theprimarydifferencebetweenthesetwocategoriesoflymphaticcanceristhetypeoflymphocytethatisaffected.HodgkinlymphomaismarkedbythepresenceofReed-Sternbergcells,whichaphysiciancanidentifyusingamicroscope.Innon-Hodgkinlymphoma,thesecellsarenotpresent.InadditiontothepresenceorlackofReed-Sternbergcells,otherdifferencesbetweenHodgkinandnon-Hodgkinlymphomaincludethat:Non-HodgkinlymphomaismorecommonthanHodgkinlymphoma.Themajorityofnon-Hodgkinpatientsareovertheageof55whenfirstdiagnosed,whereasthemedianagefordiagnosisofHodgkinlymphomais39.Non-Hodgkinlymphomamayariseinlymphnodesanywhereinthebody,whereasHodgkinlymphomatypicallybeginsintheupperbody,suchastheneck,chestorarmpits.Despitethemanydifferencesbetweenthesetwotypesoflymphaticcancer,bothhavesimilarsymptoms,suchasenlargedlymphnodes,fatigue,weightlossandfever.Ifyounoticeanyofthesesymptoms,itisimportanttoconsultwithaphysician.Whattreatmentoptionsareavailable?TreatmentforHodgkinornon-Hodgkinlymphomawilldependonthetypeoflymphaticcanceryouhave,itsstage,youroverallhealthandmanyotherfactors.AtMoffittCancerCenter,themultispecialtyexpertsthatmakeupourMalignantHematologyProgramcollaborateasatumorboardtoreviewpatientcases,ensuringeachpatientreceivesanindividualizedtreatmentplanthataddresseshisorheruniqueneeds."InbothHodgkinandnonHodgkinlymphoma,treatmentsisoneofthemostadvancedandefficaciousforcancer.Itcanr