Evaluating the Role of Hans Selye in the Modern History of ... | Selye's General adaptation syndrome

The General Adaptation SyndromeNCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.CantorD,RamsdenE,editors.Stress,Shock,andAdaptationintheTwentiethCentury.Rochester(NY):UniversityofRochesterPress;2014Feb.Stress,Shock,andAdaptationintheTwentiethCentury.ShowdetailsCantorD,RamsdenE,editors.Rochester(NY):UniversityofRochesterPress;2014Feb.ContentsSearchtermChapter1EvaluatingtheRoleofHansSelyeintheModernHistoryofStressMarkJackson.Thisisthephilosophicalpointofviewwhichaltersourconceptofdisease....Medicalmenwhorecognizetherevolutionaryandshatteringnatureofthesedevelopmentsrealizethatagreatadjustmentinourthinkinghastobemade.HereisthepoolofBethesda.J.S.L.Browne,“NewPoolofBethesda”Someyearsago,HansSelyepostulatedageneraladaptationsyndromeduetostress,butthisconcepthasbeenofdoubtfulvalueinadvancingtheunderstandingofmaladies.JohnW.Todd,“PlainWordsinMedicine”Accordingtomanystressresearchers,aswellashistorians,modernbiologicalformulationsofstresscanbetracedbacktoabriefandratherspeculativearticlewrittenbytheAustrian-bornHungarianscientistHansSelye(1907–82)in1936.Thearticlesetoutwhatappearedtobeacharacteristictriphasicpatternofnonspecificphysiologicalresponsestoinjury:the“generaladaptationsyndrome”comprisedaninitialalarmphasethatwasfollowedbyastageofresistanceoradaptation,leadingeventuallytoastageofexhaustionanddeath.1Withintraditionalnarrativesofstresshistory,whichhaveoftenbeenwrittenbyresearchersthemselvesandwhichportraytheoriginsanddevelopmentofscientificunderstandingsofstressasrelativelyunproblematicandprogressive,itwasthegeneraladaptationsyndrome,orwhatSelyesometimesreferredtoratherostentatiouslyas“Selye’ssyndrome,”thatprovidedaconceptualframeworkforSelyeandhiscolleaguestodevelopacomplexneurohormonalmodelofstressthatimplicatedpituitaryandadrenalfunctionintheetiologyofmanychronicdiseases,suchashypertension,pepticulceration,renaldisease,arthritis,a


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