Gardner's Syndrome: Symptoms, Diagnosis, and Treatment | Gardner syndrome

Gardner's syndrome is a rare genetic disorder. It usually causes what start out to be benign or noncancerous growths. It's classified as a subtype of familial ...Gardner'sSyndromeMedicallyreviewedbyStacySampson,D.O.—WrittenbyMaryAnnDePietro,CRT—UpdatedonDecember20,2017CausesRiskfactorsSymptomsDiagnosisTreatmentOutlookPreventionWhatisGardner’ssyndrome?Gardner’ssyndromeisararegeneticdisorder.Itusuallycauseswhatstartouttobebenignornoncancerousgrowths.It’sclassifiedasasubtypeoffamilialadenomatouspolyposis,whichovertimecausescoloncancer.Gardner’ssyndromecanleadtogrowthsonvariousareasofthebody.Tumorsaremostcommonlyfoundinthecolon,sometimesinlargenumbers.Theytendtoincreasewithage.Inadditiontopolypsonthecolon,growthscandevelop,includingfibromas,desmoidtumors,andsebaceouscysts,whicharefluid-filledgrowthsundertheskin.EyelesionscanalsooccurontheretinainsomeonewhohasGardner’ssyndrome.WhatcausesGardner’ssyndrome?Thesyndromeisageneticcondition,whichmeansit’sinherited.Theadenomatouspolyposiscoli(APC)genemediatestheproductionofAPCprotein.TheAPCproteinregulatescellgrowthbypreventingcellsfromdividingtoofastorinadisorderlyway.PeoplewithGardner’ssyndromehaveadefectintheAPCgene.Thisleadstoabnormaltissuegrowth.Whatcausesthemutationofthisgenehasnotbeendetermined.WhoisatriskforGardner’ssyndrome?ThemainriskfactorfordevelopingGardner’ssyndromeishavingatleastoneparentwiththecondition.AspontaneousmutationintheAPCgeneisamuchlesscommonoccurrence.SymptomsofGardner’ssyndromeCommonsymptomsofthisconditioninclude:growthsinthecolondevelopmentofextrateethbonytumorsontheskullandotherbonescystsundertheskinThemainsymptomofGardner’ssyndromeismultiplegrowthsinthecolon.Thegrowthsarealsoknownaspolyps.Althoughthenumberofgrowthsvaries,theycanbeinthehundreds.Inadditiontogrowthsonthecolon,extrateethcandevelop,alongwithbonytumorsontheskull.AnothercommonsymptomofGardner’ssyndromeiscysts,whichcanformundertheskinonvariouspartsofthebody.Fibromasandepithelialcystsarecommon.Peoplewiththesyndromealsohaveamuchhigherriskof

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Definition of Gardner syndrome | Gardner syndrome
What is Gardner Syndrome? | Gardner syndrome
Gardner syndrome is a rare variant of familial adenomatous polyposis – a condition characterized by multiple benign tumors in the colon and rectum that can ...
Dermatologic Manifestations of Gardner Syndrome ... | Gardner syndrome
Gardner syndrome, a variant of familial adenomatous polyposis (FAP), is an autosomal dominant disease characterized by GI polyps, multiple ...
Gardner Syndrome: Background, Anatomy, Pathophysiology | Gardner syndrome
In 1951, Gardner described the occurrence of familial adenomatous polyposis (FAP) with the extracolonic manifestations of intestinal polyposis, ...
Gardner syndrome | Gardner syndrome
Gardner syndrome is a variant of 'familial adenomatous polyposis' (FAP), an inherited disease that is characterised by gastrointestinal polyps, multiple osteomas ...
Gardner syndrome | Gardner syndrome
Gardner, in the early 1950s, described a kindred with intestinal characteristics of familial adenomatous polyposis (FAP), but also with a number of ...
Gardner's Syndrome: Symptoms, Diagnosis, and Treatment | Gardner syndrome
Gardner's syndrome is a rare genetic disorder. It usually causes what start out to be benign or noncancerous growths. It's classified as a subtype of familial ...
Gardner syndrome | Gardner syndrome
Gardner's syndrome | Gardner syndrome
Gardner's syndrome is a subtype of familial adenomatous polyposis (FAP). Gardner syndrome is an autosomal dominant form of polyposis characterized by the ...
長庚紀念醫院林口總院 | Gardner syndrome
Gardner's syndrome外科及內科的治療方式和家族性大腸瘜肉症一樣，致病基因也是APC。（3） Turcot syndrome：是一種自體染色體隱性遺傳疾病，目前分類將之 ...