Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and ...ArticlesDavidG.MottersheadKeeleUniversity,UnitedKingdomAbirMukherjeeRoyalVeterinaryCollege(RVC),UnitedKingdomLivioCasariniUniversityofModenaandReggioEmilia,ItalyJingXuOregonHealthandScienceUniversity,UnitedStatesTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionNecrosisandApoptosis:MorphologicalFeaturesGranulosaCellApoptosis:ThreePhenotypes,TheirInitiationandRegulationMajorApoptosisSignalingPathwaysintheOvarianFollicleMitochondrialPathwaysofApoptosisandtheBMPsRegulationofBMPR1BandFSHRandTheirInfluenceonApoptosisTheRelationshipBetweenApoptosisandOocyteQualityConclusionAuthorContributionsConflictofInterestStatementReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONReviewARTICLEFront.Endocrinol.,02March2018|https://doi.org/10.3389/fendo.2018.00061GranulosaCellApoptosisintheOvarianFollicle—AChangingViewSheenaL.P.Regan1*,PhilG.Knight2,JohnL.Yovich1,3,YeeLeung4,FrankArfuso1andArunDharmarajan11StemCellandCancerBiologyLaboratory,SchoolofPharmacyandBiomedicalSciences,CurtinHealthInnovationResearchInstitute,CurtinUniversity,Perth,WA,Australia2SchoolofBiologicalSciences,UniversityofReading,Reading,UnitedKingdom3PIVETMedicalCentre,Perth,WA,Australia4WesternAustralianGynaecologicCancerService,KingEdwardMemorialHospitalforWomen,Perth,WA,AustraliaRecentstudieschallengethepreviousviewthatapoptosiswithinthegranulosacellsofthematuringovarianfollicleisareflectionofagingandconsequentlyamarkerforpoorqualityofthecontainedoocyte.Onthecontrary,apoptosiswithinthegranulosacellsisanintegralpartofnormaldevelopmentandhaslimitedpredictivecapabilityregardingoocytequalityortheensuingpregnancyrat