Individual dysmorphic features ... Features often noted in children exposed to valproate were medial deficiency of eyebrows, infraorbital grooves, ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListArchDisChildFetalNeonatalEdv.91(2);2006MarPMC2672688ArchDisChildFetalNeonatalEd.2006Mar;91(2):F90–F95.doi: 10.1136/adc.2004.067421PMCID:PMC2672688PMID:16239295Dysmorphicfeatures:animportantcluetothediagnosisandseverityoffetalanticonvulsantsyndromesUKini,NAdab,JVinten,AFryer,andJClayton‐Smith,onbehalfoftheLiverpoolandManchesterNeurodevelopmentalStudyGroupAuthorinformationArticlenotesCopyrightandLicenseinformationDisclaimerUKini,JClayton‐Smith,AcademicUnitofMedicalGenetics,StMary'sHospital,Manchester,UKNAdab,JVinten,UniversityDepartmentofNeurosciences,Liverpool,UKAFryer,DepartmentofClinicalGenetics,AlderHeyHospital,Liverpool,UKCorrespondenceto:DrKiniAcademicUnitofMedicalGenetics,StMary'sHospital,HathersageRoad,ManchesterM130JH,UK;usha.kini@orh.nhs.ukThemembersoftheLiverpoolandManchesterNeurodevelopmentalStudyGroupareNAdab,UKini,JVinten,JAyres,GBaker,JClayton‐Smith,HCoyle,AFryer,JGorry,JGregg,GMawer,PNicolaides,LPickering,LTunnicliffe,DWChadwick.Accepted2005Aug16.Copyright©2006BMJPublishingGroup&RoyalCollegeofPaediatricsandChildHealthThisarticlehasbeencitedbyotherarticlesinPMC.BackgroundInuteroexposuretoantiepilepticdrugs(AEDs)canresultinseveraldifferentteratogeniceffectsincludingmajormalformations,dysmorphicfacialfeatures,andlearningandbehaviouralproblems.Itisestimatedthatthereisa2–3‐foldincreaseintheriskofmalformationscomparedwiththegeneralpopulation.Theriskofcognitiveimpairmentandbehaviouralproblemsislessclear.ObjectiveToreportthefrequencyandspecificityofindividualdysmorphicfeaturesandtorelatethedysmorphicfacialphenotypetodevelopmentaloutcome.MethodsAretrospectivestudyof375childrenbornto219motherswithepilepsy.Theageofthestudygrouprangedfrom6 monthsto16years.Eachchildunde