YellowfeverFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchNottobeconfusedwithmalariaorthederogatorypunreferencingAsianfetish."AmericanPlague"and"Yellowplague"redirecthere.Fortherockband,seeTheAmericanPlague.FortheYellowPlagueofRhosinmedievalWales,seeMaelgwnGwynedd.Forotheruses,seeYellowfever(disambiguation).ViraldiseaseMedicalconditionYellowFeverOthernamesYellowjack,yellowplague,[1]bronzejohn[2]ATEMmicrographofyellowfevervirus(234,000×magnification)SpecialtyInfectiousdiseaseSymptomsFever,chills,musclepain,headache,yellowskin[3]ComplicationsLiverfailure,bleeding[3]Usualonset3–6dayspostexposure[3]Duration3–4days[3]CausesYellowfevervirusspreadbymosquitoes[3]DiagnosticmethodBloodtest[4]PreventionYellowfevervaccine[3]TreatmentSupportivecare[3]Frequency~127,000severecases(2013)[3]Deaths5,100(2015)[5]Yellowfeverisaviraldiseaseoftypicallyshortduration.[3]Inmostcases,symptomsincludefever,chills,lossofappetite,nausea,musclepains–particularlyintheback–andheadaches.[3]Symptomstypicallyimprovewithinfivedays.[3]Inabout15%ofpeople,withinadayofimprovingthefevercomesback,abdominalpainoccurs,andliverdamagebeginscausingyellowskin.[3][6]Ifthisoccurs,theriskofbleedingandkidneyproblemsisincreased.[3]Thediseaseiscausedbyyellowfevervirusandisspreadbythebiteofaninfectedmosquito.[3]Itinfectsonlyhumans,otherprimates,andseveraltypesofmosquitoes.[3]Incities,itisspreadprimarilybyAedesaegypti,atypeofmosquitofoundthroughoutthetropicsandsubtropics.[3]ThevirusisanRNAvirusofthegenusFlavivirus.[7]Thediseasemaybedifficulttotellapartfromotherillnesses,especiallyintheearlystages.[3]Toconfirmasuspectedcase,blood-sampletestingwithpolymerasechainreactionisrequired.[4]Asafeandeffectivevaccineagainstyellowfeverexists,andsomecountriesrequirevaccinationsfortravelers.[3]Othereffortstopreventinfectionincludereducingthepopulationofthetransmittingmosquitoes.[3]Inareaswhereyellowfeveriscommon,earlydiagnosisofcasesandimmunizationoflargepartsofthepopulationareimportanttopreventoutbreaks.[3]Onceapersonisi