What is serrated polyposis syndrome (SPS)? · Hyperplastic polyps: These are the most common and are usually located on the left side of the ...CORONAVIRUS:DELAYSFORROUTINESURGERIES,VISITORRESTRICTIONS+COVID-19TESTING.Home/HealthLibrary/Disease&ConditionsSerratedPolyposisSyndrome/HyperplasticPolyposisSyndromeThereisnocureforserratedpolyposissyndrome(SPS),whichisarareconditioninvolvingsaw-toothedgrowthsinthecolonand/orrectum.DiagnosingSPSrequiresendoscopictestingofthecolonandrectum(acolonoscopy).Appointments216.444.7000Appointments&LocationsContactUsSerratedPolyposisSyndrome/HyperplasticPolyposisSyndromeMenuOverviewDiagnosisandTestsManagementandTreatmentPreventionOutlook/PrognosisLivingWithResourcesColon:Proximalcolonreferstothefirstpartofthecolon(alsocalledtherightsideofthecolon);thedistalcolonreferstothelastpartofthecolon(alsocalledtheleftsideofthecolon).Whatisserratedpolyposissyndrome(SPS)?Serratedpolyposissyndrome(SPS)wasformerlycalledhyperplasticpolyposissyndrome.SPSisarareconditionthatischaracterizedbyserratedpolypsinthecolonand/orrectum.Serratedpolypsareatypeofgrowththatstickoutfromthesurfaceofthecolonorrectum.Thepolypsaredefinedbytheirsaw-toothedappearanceunderthemicroscope.Theycanoftenbehardtofind.Theonlywaytodeterminethetypesofpolypsisbyremovingthemandexaminingthemunderamicroscope.Therearedifferenttypesofserratedpolyps,including:Hyperplasticpolyps:Thesearethemostcommonandareusuallylocatedontheleftsideofthecolon.Theyarenotusuallyprecancerous.However,theymightcallattentiontoright-sidedserratedspots.Sessileserratedpolyps[(SSPs),alsocalledsessileserratedadenomas(SSAs)]:Thesepolypsarebiggerandarelocatedontherightside.Theyarenotattachedbystalks.Theyarehardtofindonendoscopicexaminationandcanturnintocancersomewhatquickly.Serratedadenomas(alsocalledtraditionalserratedadenomas,orTSAs):Thesepolypsarelesscommonbuthavedysplasia(abnormalcells)andcanprogresstocancer.SPSisdefinedanddiagnosedbycriteriasetoutbytheWorldHealthOrganization(WHO).PeoplewithSPShaveahigherriskofdeve