The Letter Cancellation Task (LCT) is a widely used pen-and-paper probe of attention in clinical and research settings.ArticlesArunBokdeTrinityCollegeDublin,IrelandLaureZagoUMR5293InstitutdesMaladiesNeurodégénératives(IMN),FranceChristianHohenfeldRWTHAachenUniversity,GermanyTheeditorandreviewers'affiliationsarethelatestprovidedontheirLoopresearchprofilesandmaynotreflecttheirsituationatthetimeofreview.AbstractIntroductionMaterialsandMethodsResultsDiscussionConclusionEthicsStatementAuthorContributionsFundingConflictofInterestStatementFootnotesReferencesSuggestaResearchTopic>DownloadArticleDownloadPDFReadCubeEPUBXML(NLM)SupplementaryMaterialExportcitationEndNoteReferenceManagerSimpleTEXTfileBibTextotalviewsViewArticleImpactSuggestaResearchTopic>SHAREONOpenSupplementalDataORIGINALRESEARCHarticleFront.Hum.Neurosci.,16April2019|https://doi.org/10.3389/fnhum.2019.00097FunctionalMRIofLetterCancellationTaskPerformanceinOlderAdultsIvyD.Deng1,LukeChung2,NatashaTalwar3,4,FredTam1,NathanW.Churchill3,TomA.Schweizer3,4,5,6†andSimonJ.Graham1,2*†1PhysicalSciencesPlatform,SunnybrookResearchInstitute(SRI),Toronto,ON,Canada2DepartmentofMedicalBiophysics,UniversityofToronto,Toronto,ON,Canada3NeuroscienceResearchProgram,KeenanResearchCentreforBiomedicalScience,Toronto,ON,Canada4InstituteofMedicalScience,UniversityofToronto,Toronto,ON,Canada5DivisionofNeurosurgery,St.Michael’sHospital,Toronto,ON,Canada6InstituteofBiomaterialsandBiomedicalEngineering,UniversityofToronto,Toronto,ON,CanadaTheLetterCancellationTask(LCT)isawidelyusedpen-and-paperprobeofattentioninclinicalandresearchsettings.Despiteitspopularity,theneuralcorrelatesofthetaskarenotwellunderstood.Thepresentstudyusesfunctionalmagneticresonanceimaging(fMRI)andspecializedtablettechnologytoidentifytheneuralcorrelatesoftheLCTin32healthyolderadultsbetween50–85yearsofage,andfurtherinvestigatestheeffectofhealthyagingonperformance.SubjectsperformedtheLCTinitsstandardpen-and-paperadministrationandwiththetabletduringfMRI.Performanceonthetabl