Here we describe a rare case of Capgras delusion – a misidentification syndrome characterized by the belief that a person has ... Intriguingly, delusional belief was selective for both person and modality, as the ... 中文翻译： ...搜索当前位置：X-MOL学术›Cortex›论文详情Catchingtheimposterinthebrain:ThecaseofCapgrasdelusion.Cortex(IF4.009)PubDate : 2020-05-19,DOI:10.1016/j.cortex.2020.04.025ArturoNuara,YleniaNicolini,PiergiorgioD'Orio,FrancescoCardinale,GiacomoRizzolatti,PietroAvanzini,MaddalenaFabbri-Destro,DorianaDeMarcoHerewedescribeararecaseofCapgrasdelusion–amisidentificationsyndromecharacterizedbythebeliefthatapersonhasbeenreplacedbyanimposter–inapatientwithoutevidentneurologicalorpsychiatricsymptoms.Intriguingly,delusionalbeliefwasselectiveforbothpersonandmodality,asthepatientbelievedthathisson–nothisdaughterorotherrelatives–wassubstitutedwithanimposteronlywhilebeinginpresenceofhimandlookingathisface,butnotwhenmerelylisteningtohisvoice.Aneuroanatomicalreconstructionobtainedintegratingmorphologicalandfunctionalpatient’sneuroimagingdatahighlightedtwomainpeculiarities:acompressionoftherostralportionofrighttemporallobeduetoalargearachnoidcyst,andabilaterallyreducedmetabolismoffrontalareas.Autonomicdataobtainedfromthermalinfra-redcameraandskinconductancerecordingsshowedthatahighersympatheticactivationwasevokedbytheobservationofdaughter’sface,relativetotheobservationoftheson’sfaceaswellasofnot-familiarfaces;conversely,daughterandsonvoiceselicitedasimilarsympatheticactivation,higherrelativetonot-familiarvoices,indicatingamodality-dependentdissociationconsistentwiththedelusionalbehavior.Ourcasesupportsthe“two-hithypothesis”aboutCapgrasdelusionetiopathogenesis:here,thefirsthitisrepresentedbytheright-temporallesionimpairingtheassociationbetweenfamiliarfacesandemotionalvalues,thesecondoneisthefrontalbilateralhypometabolismfavoringdelusionalbehavior.Theselectiveoccurrenceof“imposter”delusionforaparticularsubjectandforaspecificperceptualmodalitysuggeststheinvolvementofmodality-specificinter