Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermTypeIHypersensitivityReactionMalakAbbas;MohamedMoussa;HassanAkel.AuthorInformationAuthorsMalakAbbas1;MohamedMoussa2;HassanAkel3.Affiliations1BeaumontHealth2BeaumontHealth3BeaumontHealthLastUpdate:May4,2021.ContinuingEducationActivityTypeIhypersensitivityisalsoknownasanimmediatereactionandinvolvesimmunoglobulinE(IgE)mediatedreleaseofantibodiesagainstthesolubleantigen.ThisactivityreviewstheevaluationandmanagementoftypeIhypersensitivityandreviewstheroleoftheinterprofessionalteamsinmanagingpatientswiththiscondition.Objectives:IdentifytheetiologyoftypeIhypersensitivitymedicalconditionsandemergencies.SummarizetheevaluationoftypeIhypersensitivity.OutlinethemanagementoptionsavailablefortypeIhypersensitivity.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionTheimmunesystemplaysacrucialroleinmaintaininghealthandprotectingthehumanbodyagainstmicrobialinvasions.However,thissamesystemcanleadtoexaggeratedimmuneandinflammatoryresponsesthatresultinadverseoutcomesknownashypersensitivityreactions.Therearefourtraditionalclassificationsforhypersensitivityreactions,andtheseincludeTypeI,TypeII,TypeIII,andTypeIVreactions:[1]TypeIhypersensitivityisalsoknownasanimmediatereactionandinvolvesimmunoglobulinE(IgE)mediatedreleaseofantibodiesagainstthesolubleantigen.Thisresultsinmastcelldegranulationandreleaseofhistamineandotherinflammatorymediators.TypeIIhypersensitivityisalsoknownascytotoxicreactionsandengagesIgGandIgMantibodies,leadingtothecomplementsystemactivationandcelldamageorlysis.TypeIIIhypersensitivityisa