AmpC beta-lactamase antibiotics延伸文章資訊，搜尋引擎最佳文章推薦
1. AmpC beta-lactamases
Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19InformationPublichealthinformation(CDC)Researchinformation(NIH)SARS-CoV-2data(NCBI)Preventionandtreatmentinformation(HHS)Español AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:1selecteditem:19136439-PubMedTo:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyFulltextlinksAtyponFreePMCarticleFulltextlinksActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSharePermalinkCopyPagenavigationTitle&authorsAbstractFiguresSimilararticlesCitedbyPublicationtypesMeSHtermsSubstancesRelatedinformationLinkOut-moreresourcesTitle&authorsAbstractFiguresSimilararticlesCitedbyPublicatio
2. Meropenem versus piperacillin-tazobactam for ...
SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFStudyprotocolOpenAccessPublished:27January2015Meropenemversuspiperacillin-tazobactamfordefinitivetreatmentofbloodstreaminfectionsduetoceftriaxonenon-susceptibleEscherichiacoliandKlebsiellaspp(theMERINOtrial):studyprotocolforarandomisedcontrolledtrialPatrickNAHarris1,AntonYPeleg2,JonIredell3,PaulRIngram4,5,SpirosMiyakis6,AndrewJStewardson7,BenjaminARogers8,EmmaSMcBryde9,JasonARoberts10,JeffLipman10,EugeneAthan11,SanjoyKPaul12,PeterBaker13,TiffanyHarris-Brown1&DavidLPaterson1 Trialsvolume 16,Article number: 24(2015)Citethisarticle14kAccesses46Citations5AltmetricMetricsdetailsAbstractBackgroundGram-negativebacteriasuchasEscherichiacoliorKlebsiellaspp.frequentlycausebloodstreaminfections.Therehasbeenaworldwideincreaseinresistanceinthesespeciestoantibioticssuchasthirdgenerationcephalosporins,largelydrivenbytheacquisitionofextended-spectrumbeta-lactamaseorplasmid-mediatedAmpCenzymes.Carbapenemshavebeenconsideredthemosteffectivetherapyforseriousinfectionscausedbysuchresistantbacteria;however,increasedusecreatesselectionpressureforcarbapenemresistance,anemergingthreatarisingpredominantlyfromthedisseminationofgenesencodingcarbapenemases.Recentretrospectivedatasuggestthatbeta-lactam/beta-lactamaseinhibitorcombinations,suchaspiperacillin-tazobactam,maybenon-inferiortocarbapenemsforthetreatmentofbloodstreaminfectioncausedbyextended-spectrumbeta-lactamase-producers,ifsusceptibleinvitro.Thisstudyaimstotestthishypothesisinanefforttodefinecarbapenem-sparingalternativesfortheseinfections.Methods/DesignThestudywilluseamulticentrerandomisedcontrolledopen-labelnon-inferioritytrialdesigncomparingtwotreatments,meropenem(standardarm)andpiperacillin-tazobactam(carbapenem-sparingarm)inadultpatientswithbacteraemiacausedbyE.coliorKlebsiellaspp.demonstratingnon-susceptibilitytothirdgenerationcephalosporins.Recruitmentisplannedtooccurinsitesacrossthreecountries(Australia,NewZealandandSingapore).Atotalsamplesizeof454patientswillb
3. ESBL and AmpC-producing antimicrobial resistant bacteria
DirektzumInhaltspringenDirektzurServicenavigationspringen NavigationundServiceServicemenüHomepageSitemapContact-AA+AGermanSchnellsucheSearch advancedsearchA-ZIndexABCDEFGHIJKLMNOPQRSTUVWXYZSearchA-ZIndexHauptmenüTheInstituteMissionstatementFacts&FiguresRemitTheBfRstructureWorkingattheBfRScientificAdvisoryBoardPrinciplesofScientificPracticeDatabasesGLPFederalBureauQualitymanagementEnvironmentalManagementTheBfR-CommitteesCo-operationNationalBreastfeedingCommitteeReferenceLaboratoriesEFSAFocalPointGermanCentrefortheProtectionofLaboratoryAnimals(Bf3R)FoodsafetyMicrobialrisksSubstancerisksFeedsNutritionalrisksSpecialfoodgroupsProductSafetyFoodcontactmaterialsCosmeticsToysTextilesTobaccoproductsOtherconsumerproductsNanotechnologyChemicalSafetyREACH-thenewEuropeanchemicalslegislationBiocidalproductsandtreatedgoodsPlantprotectionproductsTransportofdangerousgoodsPoisoningsYouarehere:HomepageFAQESBLandAmpC-producingantimicrobialresistantbacteriaweitereThemendesBFRRiskcommunicationResearchScienceNewsPressofficePublicationsEventsoftheBfRAcademyFAQNewNewsletterRSS-FeedJobadvertisementNotepadQuestionsandanswersonESBLandAmpC-producingantimicrobialresistantbacteriaUpdatedFAQattheBfRof19January2015Bacteriacanberesistanttocertainantibiotics.Whenthishappenswithpathogenicbacteria,theseantibioticsremainineffectiveiftheyareusedtotreatanillnesscausedbythebacteria.Importantantimicrobialstowardswhichincreasingresistancehasbeenobservedincludethegroupofaminopenicillinsandcephalosporins.Oneofthecausesofthisantimicrobialresistanceareenzymesdesignatedas"extended-spectrumbeta-lactamases"(ESBL)and"ampCbeta-lactamases"(AmpC).Bacteriarequireacertain"resistancegene"inordertoproducetheseenzymes.Thisgeneticpropertycanbepassedonfromonebacteriagenerationtothenextthroughcelldivisionduringpropagation.Duringthelifetimeofabacterium,however,itcanalsobepassedonfromonebacteriacelltoanotherontransmissiblegenesectionssuchasplasmids.Thesetwocellscanalsobelongtodifferentbacteriatypes.Theuseofantibioticsinhumansanda
4. AmpC and extended spectrum beta-lactamases production ...
Similarly, AmpC β-lactamases producing organisms are resistant to narrow, broad-, and expanded-spectrum cephalosporins and cephamycins and can ...SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFResearcharticleOpenAccessPublished:07September2017AmpCandextendedspectrumbeta-lactamasesproductionamongurinaryisolatesfromatertiarycarehospitalinLalitpur,NepalSumanRai1,NarayanDuttPant2,RajuBhandari3,AnilGiri3,RoshanParajuli4,ManojAryal1,JyotiAmatya1&VijayKumarSharma5 BMCResearchNotesvolume 10,Article number: 467(2017)Citethisarticle1795Accesses2Citations1AltmetricMetricsdetailsAbstractBackgroundProductionofAmpCandextendedspectrumbeta-lactamasesamongurinaryisolateshascreatedaseriousproblemtothesuccessfulmanagementoftheurinarytractinfection.Themainpurposeofthisstudywastodeterminetheratesoftheextendedspectrumbeta-lactamase(ESBL)productionandAmpCbeta-lactamase(ABL)productionamongurinaryisolates.ResultsAmongtotal564urinaryisolates,514(91.1%)weregramnegativebacilliand50(8.9%)weregrampositivecocci.E.coli(76.1%)wasthemostcommonbacteriaisolated.Staphylococcusaureus(6.7%)wasthepredominantgrampositivebacteriaisolated.35(6.8%)ofthe514 gramnegativebacilliwereESBLproducers.Similarly,14(2.7%)ofthegramnegativebacilliwereABLproducers.OnlyoneisolatewasESBLandABLco-producer.Highestrateofsusceptibilityofgramnegativebacteriawasseentowardamikacin(97.3%)followedbyimipenem(94.4%).Similarly,highestrateofsusceptibilityamonggrampositivecocciwasseentowardvancomycin(100%)followedbyamikacin(93.5%).ConclusionsLowratesofAmpCandextendedspectrumbeta-lactamasesproductionincomparisontootherpreviousstudieswerereported.Onthebasisoftheantimicrobialsusceptibilitypatternsofthebacteriawereportedinourstudy,amikacin,imipenemandnitrofurantoincanbeusedforthepreliminarytreatmentofurinarytractinfectionscausedbygramnegativebacteriaandvancomycinandamikacinfortreatmentofurinarytractinfectionscausedbygrampositivebacteria.BackgroundUrinarytractinfectionisamongthecommonlyencounteredbacterialinfectionsinhuman[
5. AmpC β-Lactamases
NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutTryoutPMCLabsandtelluswhatyouthink.LearnMore.JournalListClinMicrobiolRevv.22(1);2009JanPMC2620637ClinMicrobiolRev.2009Jan;22(1):161–182.doi: 10.1128/CMR.00036-08PMCID:PMC2620637PMID:19136439AmpCβ-LactamasesGeorgeA.Jacoby*GeorgeA.JacobyLaheyClinic,Burlington,MassachusettsFindarticlesbyGeorgeA.JacobyAuthorinformationCopyrightandLicenseinformationDisclaimerLaheyClinic,Burlington,Massachusetts*Mailingaddress:LaheyClinic,41MallRoad,Burlington,MA01805.Phone:(781)744-2928.Fax:(781)744-5486.E-mail:[email protected]©2009,AmericanSocietyforMicrobiologyThisarticlehasbeencitedbyotherarticlesinPMC.Summary:AmpCβ-lactamasesareclinicallyimportantcephalosporinasesencodedonthechromosomesofmanyoftheEnterobacteriaceaeandafewotherorganisms,wheretheymediateresistancetocephalothin,cefazolin,cefoxitin,mostpenicillins,andβ-lactamaseinhibitor-β-lactamcombinations.Inmanybacteria,AmpCenzymesareinducibleandcanbeexpressedathighlevelsbymutation.Overexpressionconfersresistancetobroad-spectrumcephalosporinsincludingcefotaxime,ceftazidime,andceftriaxoneandisaproblemespeciallyininfectionsduetoEnterobacteraerogenesandEnterobactercloacae,whereanisolateinitiallysusceptibletotheseagentsmaybecomeresistantupontherapy.TransmissibleplasmidshaveacquiredgenesforAmpCenzymes,whichconsequentlycannowappearinbacterialackingorpoorlyexpressingachromosomalblaAmpCgene,suchasEscherichiacoli,Klebsiellapneumoniae,andProteusmirabilis.Resistanceduetoplasmid-mediatedAmpCenzymesislesscommonthanextended-spectrumβ-lactamaseproductioninmostpartsoftheworldbutmaybebothhardertodetectandbroaderinspectrum.AmpCenzymesencodedbybothchromosomalandplasmidgenesarealsoevolvingtohydrolyzebroad-spectrumcephalosporinsmoreefficiently.TechniquestoidentifyAmpCβ-lactamase-producingisolatesareavailablebutarestillevolvingandarenotyetoptimizedfortheclinicallaboratory,whichprobablynowunderestimatesthisresistancemechanism.Carbapenemscanusuall