Attenuated familial adenomatous polyposis is a form of familial adenomatous polyposis, a cancer syndrome. It is a pre-malignant disease that can develop into ...AttenuatedfamilialadenomatouspolyposisFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchAttenuatedfamilialadenomatouspolyposisOthernamesAttenuatedfamilialpolyposiscoliSpecialtyOncologyAttenuatedfamilialadenomatouspolyposisisaformoffamilialadenomatouspolyposis,acancersyndrome.Itisapre-malignantdiseasethatcandevelopintocolorectalcancer.Apatientwillhavefewerthanahundredpolypslocatedtypicallyinrightsideofthecolon.Cancermightdevelopasearlyastheageoffive,thoughtypicallypresentslaterthanclassicalFAP.[1]Seealso[edit]FamilialadenomatouspolyposisBirt–Hogg–DubésyndromeCowdensyndromeCronkhite–CanadasyndromeJuvenilepolyposisMUTYHPeutz–JegherssyndromeReferences[edit]^Herold,Gerd(2012).InnereMedizin :einevorlesungsorientierteDarstellung(2012 ed.).Köln:Herold.ISBN 978-3-9814660-1-0.Externallinks[edit]ClassificationDICD-10:D12.6MeSH:C538265C538265,C538265ExternalresourcesOrphanet:220460Thisarticleaboutaneoplasmisastub.YoucanhelpWikipediabyexpandingit.vteRetrievedfrom"https://en.wikipedia.org/w/index.php?title=Attenuated_familial_adenomatous_polyposis&oldid=952370184"Categories:GastrointestinalcancerHereditarycancersNeoplasmstubsHiddencategories:AllstubarticlesNavigationmenuPersonaltoolsNotloggedinTalkContributionsCreateaccountLoginNamespacesArticleTalkVariantsViewsReadEditViewhistoryMoreSearchNavigationMainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonateContributeHelpLearntoeditCommunityportalRecentchangesUploadfileToolsWhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitemPrint/exportDownloadasPDFPrintableversionLanguagesAddlinks

Attenuated familial adenomatous polyposis: An inherited predisposition to colorectal cancer characterized by fewer than 100 adenomatous polyps in the colon and rectum. It is said to be attenuated because there are fewer polyps than in classic familial adenomatous polyposis (FAP).Attenuatedfamilialadenomatouspolyposis:Aninheritedpredispositiontocolorectalcancercharacterizedbyfewerthan100adenomatouspolypsinthecolonandrectum.Itissaidtobeattenuatedbecausetherearefewerpolypsthaninclassicfamilialadenomatouspolyposis(FAP).Peoplewithattenuatedfamilialadenomatouspolyposis(AFAP)alsotendtobeolderatthediagnosisoftheirpolyps(averageageof44years)andcancer(averageageof56years),10to15yearslaterthaninclassicFAP.TherightsideofthecolontendstobeinvolvedinAFAPandrectalinvolvementisrare.AFAPistransmittedinanautosomaldominantmanner.PeoplewithAFAPoftenbelongtofamiliesthatalsohavememberswithclassicFAP.AsinFAP,theremayalsobepolypshigherupintheintestinaltractintheduodenumandstomachandanelevatedriskofstomach,liver,andbreastcancer.AndasinFAP,AFAPisassociatedwithmutationsintheAPCgene(insomecases).APCgenetestingcanthereforebeinformativeinpeoplesuspectedofhavingAFAP.IfAPCtestingisnegative,thengenetictestingforMYHmutations(anotherhereditarycauseofcolorectalcancer)maybewarranted.IthasbeenrecommendedthatAFAPpatientshavecolonoscopyratherthansigmoidoscopybecausetheadenomatouspolypsarepredominantlyright-sidedandbeyondthereachofasigmodoscope.Theroleforandtimingofprophylacticcolectomy(precautionaryremovalofthecolon)inAFAPiscontroversial.Onthemolecularlevel,mutationsintheAPCgeneinFAPandAFAPhavebeenfoundinthreedifferentregionsofthegene:Atthe5'endoftheAPCgene,spanningexons4and5;Withinexon9oftheAPCgene;andAtthe3'endoftheAPCgene.Ithasbeenproposedthatmutationsinregion1areassociatedwithagreatrangeinthenumberofcolorectalpolyps(from2tomorethan500)andwiththepresenceofupperintestinalpolyps;thatmutationsinregion2areassociatedwiththepresenceoffrom1to150colorectalpolyps,butnoupperintestinalpolyps;andthatmutationsinregi

Familial adenomatous polyposis (FAP) is an inherited disorder characterized by the early onset of multiple adenomatous polyps in the colon and ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturehumangenomevariationdatareportsarticleAttenuatedfamilialadenomatouspolyposiswithdesmoidscausedbyanAPCmutationDownloadPDFSubjectsCancergeneticsAbstractWepresenthereacaseofattenuatedfamilialadenomatouspolyposis(AFAP)withafamilyhistoryofdesmoidsandthyroidtumors.Thispatienthadnocolonicpolypsbutdidhavemultipledesmoids.Geneticanalysisidentifieda4-bpdeletionincodon2644(c.7932_7935delTTAT:p.Tyr2645LysfsX14)oftheadenomatouspolyposiscoli(APC)gene.Incaseswithlimitednumbersofcolonicpolypsanddesmoids,AFAPmaybecausedbyamutationinthe3′regionofAPC.DownloadPDFFamilialadenomatouspolyposis(FAP)isaninheriteddisordercharacterizedbytheearlyonsetofmultipleadenomatouspolypsinthecolonandrectum.Unlessthecolonisremoved,mostpatientswiththissyndromedevelopcolorectalcancerbytheageof35–40years.Gardner’ssyndromeisavariantofFAPcharacterizedbycolonicpolyposis,osteomasandsofttissuetumors,suchasdesmoids.Desmoidtumorsarebenign,non-inflammatoryfibroblasticneoplasmsthattendtobelocallyinvasivebutarenotmetastatic.However,theyhaveahighpotentialforlocalrecurrencefollowingsurgicalresection.UppergastrointestinalneoplasmsarealsotypicalextracolonicmanifestationsinFAP.Histologically,themajorityofduodenalpolypsareadenomas,whereasthemajorityofgastricpolypsarefundicglandpolyps.Similartootherhereditarycancersyndromes,thereisanincreasedriskofadditionalmalignanciesinFAP,includingthyroidcancer.Germlinemutationsoftheadenomatouspolyposiscoli(APC)genethatisresponsibleforFAPmayalsocauseGardner’ssyndrome.CorrelationshavebeenobservedbetweenmutationinAPCandtheFAPphenotype.Mu

Attenuated familial adenomatous polyposis, or AFAP, is a type of polyposis, in which polyps occur on the colon, which can lead to cancer. Read more here.CloseOpenShareonFacebookTwitterGoogle+Email Notice:Usersmaybeexperiencingissueswithdisplayingsomepagesonstanfordhealthcare.org.Weareworkingcloselywithourtechnicalteamstoresolvetheissueasquicklyaspossible.Thankyouforyourpatience. COVID-19Updates:    COVID-19Resources »    VaccineUpdate»    UpdatedVisitorPolicy »     WhatWe'reDoingtoKeepYouSafe »MenuSearchMenuSearchDoctors,Clinics&Locations,Conditions&TreatmentsPatients&VisitorsMyHealthBillingInsuranceMedicalRecordsSupportGroupsFinancialAssistanceCOVID-19ResourceCenterLocationsandParkingVisitorPolicyHospitalCheck-inInternationalPatientsContactUsViewAllInformationforPatients&Visitors»Weareavailabletoassistyou24/7.650-498-3333GuestServices@stanfordhealthcare.orgViewthechangestoourvisitorpolicy » ViewinformationforGuestServices»NewtoMyHealth?ManageYourCareFromAnywhere.AccessyourhealthinformationfromanydevicewithMyHealth. Youcanmessageyourclinic,viewlabresults,scheduleanappointment,andpayyourbill.ALREADYHAVEANACCESSCODE?ActivateAccountDON'THAVEANACCESSCODE?CreateaNewAccountNEEDMOREDETAILS?LearnMoreaboutMyHealth»MyHealthforMobileGettheiPhoneMyHealthapp»GettheAndroidMyHealthapp»WELCOMEBACKForgotUsernameorPassword?NeedHelp?ClearAttenuatedFAPAboutAboutOverviewCausesTumorsuppressorgeneGenotype-phenotypevariationsAttenuatedFAPI1307KmutationDiagnosisSigmoidoscopyColonoscopyTreatmentsPreventionOverviewCausesTumorsuppressorgeneGenotype-phenotypevariationsAttenuatedFAPI1307KmutationDiagnosisSigmoidoscopyColonoscopyTreatmentsPreventionWhatIsAttenuatedFAP?Anattenuatedformoffamilialadenomatouspolyposis(AFAP)hasbeenidentified.IndividualswithAFAPdevelopfewerthan100adenomatouspolyps(averageof30polyps)andthepolypsaremorelikelytooccurontherightsideofthecolonthaninclassicFAP.Theriskofdevelopingcoloncancerisincreased,buttheaverageageofdiagnosisisolder(50to55yearsofage)thanintheclassi

Over the last decade, a subset of familial adenomatous polyposis (FAP) patients with a milder course of disease termed attenuated familial adenomatous ...Clipboard,SearchHistory,andseveralotheradvancedfeaturesaretemporarilyunavailable.SkiptomainpagecontentCOVID-19isanemerging,rapidlyevolvingsituation.GetthelatestpublichealthinformationfromCDC:https://www.coronavirus.govGetthelatestresearchinformationfromNIH:https://www.nih.gov/coronavirusFindNCBISARS-CoV-2literature,sequence,andclinicalcontent:https://www.ncbi.nlm.nih.gov/sars-cov-2/ AccesskeysNCBIHomepageMyNCBIHomepageMainContentMainNavigationSearch:SearchAdvancedClipboardUserGuideSaveEmailSendtoClipboardMyBibliographyCollectionsCitationmanagerDisplayoptionsDisplayoptionsFormatAbstractPubMedPMIDSavecitationtofileFormat:Summary(text)PubMedPMIDAbstract(text)CSVCreatefileCancelEmailcitationSubject:To:Format:SummarySummary(text)AbstractAbstract(text)MeSHandotherdataSendemailCancelAddtoCollectionsCreateanewcollectionAddtoanexistingcollectionNameyourcollection:Namemustbelessthan100charactersChooseacollection:UnabletoloadyourcollectionduetoanerrorPleasetryagainAddCancelAddtoMyBibliographyMyBibliographyUnabletoloadyourdelegatesduetoanerrorPleasetryagainAddCancelYoursavedsearchNameofsavedsearch:Searchterms:TestsearchtermsWouldyoulikeemailupdatesofnewsearchresults?SavedSearchAlertRadioButtonsYesNoEmail:(change)Frequency:MonthlyWeeklyDailyWhichday?ThefirstSundayThefirstMondayThefirstTuesdayThefirstWednesdayThefirstThursdayThefirstFridayThefirstSaturdayThefirstdayThefirstweekdayWhichday?SundayMondayTuesdayWednesdayThursdayFridaySaturdayReportformat:SummarySummary(text)AbstractAbstract(text)PubMedSendatmost:1item5items10items20items50items100items200itemsSendevenwhentherearen'tanynewresultsOptionaltextinemail:SaveCancelCreateafileforexternalcitationmanagementsoftwareCreatefileCancelYourRSSFeedNameofRSSFeed:Numberofitemsdisplayed:510152050100CreateRSSCancelRSSLinkCopyActionsCiteFavoritesDisplayoptionsDisplayoptionsFormatAbstract

Three hereditary syndromes in which germline mutations can lead to colorectal carcinogenesis are familial adenomatous polyposis (FAP), ...×Title(Title)MrMsDr.ProfessorFirstName*LastName*Company/InstitutionE-Mail*Message*indicatesrequiredfieldsThissiteisprotectedbyreCAPTCHAandtheGooglePrivacyPolicyandTermsofServiceapply.00×JournalsBooksCollectionsSubjectGuideLogin00JournalMenuJournalHomeAboutThisJournalGuidelinesJournalContactSubscriptionRatesRelatedArticlesContents:allyears×DigestiveDiseasesDownloadFulltextPDFSmallandLargeBowel:ReviewFreeAccessAppropriateManagementofAttenuatedFamilialAdenomatousPolyposis:ReportofaCaseandReviewoftheLiteratureSokic-MilutinovicA.a,bAuthoraffiliationsaClinicforGastroenterologyandHepatology,ClinicalCenterofSerbia,Belgrade,SerbiabSchoolofMedicine,UniversityofBelgrade,Belgrade,SerbiaCorrespondingAuthorProf.Dr.AleksandraSokicMilutinovic,MD,PhDClinicforGastroenterologyandHepatologyClinicalCenterofSerbiaKosteTodorovica2RS–11000Belgrade(Serbia)[email protected]:AttenuatedfamilialadenomatouspolyposisScreeningExtracolonicmalignanciesRelatedArticlesfor""DigDis2019;37:400–405https://doi.org/10.1159/000497207AbstractFullTextPDFReferencesExtras:1AbstractHereditarypolyposissyndromesinwhichAPCgenegermlinemutationscanleadtocolorectalcarcinogenesisarefamilialadenomatouspolyposis(FAP),attenuatedFAP(AFAP)andMUTYH-associatedpolyposis.All3syndromesincreasethepotentialforthedevelopmentofcolorectalcancer.AFAPisdiagnosediflessthan100adenomasaredetectedinthecolonatpresentation.AFAPisinheritedinanautosomaldominantmanner.Wepresentacaseofa22-year-oldfemalewithAFAPwhowastreatedwithendoscopicpolypectomyandsurveilledbyannualcolonoscopy.GuidelinesforAFAPsurveillancesuggestannualcolonoscopywithendoscopicpolypectomyinasymptomaticindividuals.Indicationsforimmediatesurgeryincludedocumentedorsuspectedcancerorsignificantsymptoms.PreferredsurgicaloptioninAFAPiscolectomyandileo-rectalanastomosis.SurveillanceoftheAFAPpatientsshouldincludeupperGIendoscop

Familial adenomatous polyposis (FAP), a rare disorder that causes hundreds or even thousands of polyps to develop in the lining of your colon ...COVID-19:Advice,updatesandvaccineoptionsWeareopenforsafein-personcare.Learnmore:MayoClinicfactsaboutcoronavirusdisease2019(COVID-19)OurCOVID-19patientandvisitorguidelines,plustrustedhealthinformationLateston COVID-19vaccination bysite:ArizonapatientvaccinationupdatesArizona,FloridapatientvaccinationupdatesFlorida,RochesterpatientvaccinationupdatesRochesterandMayoClinicHealthSystempatientvaccinationupdatesMCHSSkiptositenavigationSkiptoContentThiscontentdoesnothaveanEnglishversion.ThiscontentdoesnothaveanArabicversion.SectionsforColonpolypsSymptoms&causesDiagnosis&treatmentDoctors&departmentsCareatMayoClinicPrintOverviewAcolonpolypisasmallclumpofcellsthatformsontheliningofthecolon.Mostcolonpolypsareharmless.Butovertime,somecolonpolypscandevelopintocoloncancer,whichisoftenfatalwhenfoundinitslaterstages.Therearetwomaincategoriesofpolyps,non-neoplasticandneoplastic.Non-neoplasticpolypsincludehyperplasticpolyps,inflammatorypolypsandhamartomatouspolyps.Thesetypesofpolypstypicallydonotbecomecancerous.Neoplasticpolypsincludeadenomasandserratedtypes.Ingeneral,thelargerapolyp,thegreatertheriskofcancer,especiallywithneoplasticpolyps.Anyonecandevelopcolonpolyps.You'reathigherriskifyou're50orolder,areoverweightorasmoker,orhaveapersonalorfamilyhistoryofcolonpolypsorcoloncancer.Colonpolypsoftendon'tcausesymptoms.It'simportanttohaveregularscreeningtests,suchasacolonoscopy,becausecolonpolypsfoundintheearlystagescanusuallyberemovedsafelyandcompletely.Thebestpreventionforcoloncancerisregularscreeningforpolyps.Products&ServicesBook:MayoCliniconDigestiveHealthSymptomsColonpolypsoftencausenosymptoms.Youmightnotknowyouhaveapolypuntilyourdoctorfindsitduringanexaminationofyourbowel.Butsomepeoplewithcolonpolypsexperience:Rectalbleeding.Thiscanbeasignofcolonpolypsorcancerorotherconditions,suchashemorrhoidsorminortearsinyouranus.Changeinstoolcolor.Bloo