Three hereditary syndromes in which germline mutations can lead to colorectal carcinogenesis are familial adenomatous polyposis (FAP), ...×Title(Title)MrMsDr.ProfessorFirstName*LastName*Company/InstitutionE-Mail*Message*indicatesrequiredfieldsThissiteisprotectedbyreCAPTCHAandtheGooglePrivacyPolicyandTermsofServiceapply.00×JournalsBooksCollectionsSubjectGuideLogin00JournalMenuJournalHomeAboutThisJournalGuidelinesJournalContactSubscriptionRatesRelatedArticlesContents:allyears×DigestiveDiseasesDownloadFulltextPDFSmallandLargeBowel:ReviewFreeAccessAppropriateManagementofAttenuatedFamilialAdenomatousPolyposis:ReportofaCaseandReviewoftheLiteratureSokic-MilutinovicA.a,bAuthoraffiliationsaClinicforGastroenterologyandHepatology,ClinicalCenterofSerbia,Belgrade,SerbiabSchoolofMedicine,UniversityofBelgrade,Belgrade,SerbiaCorrespondingAuthorProf.Dr.AleksandraSokicMilutinovic,MD,PhDClinicforGastroenterologyandHepatologyClinicalCenterofSerbiaKosteTodorovica2RS–11000Belgrade(Serbia)[email protected]:AttenuatedfamilialadenomatouspolyposisScreeningExtracolonicmalignanciesRelatedArticlesfor""DigDis2019;37:400–405https://doi.org/10.1159/000497207AbstractFullTextPDFReferencesExtras:1AbstractHereditarypolyposissyndromesinwhichAPCgenegermlinemutationscanleadtocolorectalcarcinogenesisarefamilialadenomatouspolyposis(FAP),attenuatedFAP(AFAP)andMUTYH-associatedpolyposis.All3syndromesincreasethepotentialforthedevelopmentofcolorectalcancer.AFAPisdiagnosediflessthan100adenomasaredetectedinthecolonatpresentation.AFAPisinheritedinanautosomaldominantmanner.Wepresentacaseofa22-year-oldfemalewithAFAPwhowastreatedwithendoscopicpolypectomyandsurveilledbyannualcolonoscopy.GuidelinesforAFAPsurveillancesuggestannualcolonoscopywithendoscopicpolypectomyinasymptomaticindividuals.Indicationsforimmediatesurgeryincludedocumentedorsuspectedcancerorsignificantsymptoms.PreferredsurgicaloptioninAFAPiscolectomyandileo-rectalanastomosis.SurveillanceoftheAFAPpatientsshouldincludeupperGIendoscop