Bartonella quintana infection (historically called 'trench fever') is a vector-borne disease primarily transmitted by the human body louse. It has been recognised ...SkiptomaincontentGlobalNavigationOthersites:ECDCEuropeanAntibioticAwarenessDayESCAIDE-ScientificconferenceEurosurveillancejournalEVIP-VaccinationportalHomeAlltopics:AtoZBartonellaquintanainfection/trenchfeverFactsBartonellaquintanainfection/trenchfeverFactsFactsaboutBartonellaquintanainfection(‘trenchfever’)FactsheetTwitterFacebookLinkedInMailDisclaimer:Theinformationcontainedinthisfactsheetisintendedforthepurposeofgeneralinformationandshouldnotsubstituteindividualexpertadviceandjudgementofhealthcareprofessionals.Introduction Bartonellaquintanainfection(historicallycalled‘trenchfever’)isavector-bornediseaseprimarilytransmittedbythehumanbodylousePediculushumanushumanus.Theinfectionisassociatedwithawidevarietyofclinicalconditions,includingchronicbacteraemia,endocarditis,lymphadenopathyandbacillaryangiomatosis.Sincethe1990s,ithasbeenrecognisedasareemergingpathogenamongimpoverishedandhomelesspopulations—so-called‘urbantrenchfever’—livinginunsanitaryconditionsandcrowdedareaspredisposingthemtoinfestationwithectoparasitesthatmaytransmittheinfection.Primarypreventionoftrenchfeverreliesonmeasuresforavoidinginfestationwithbodylice.Thepathogen  B.quintanaisslow-growingGram-negativebacteriumwithshortrodsmorphology(0.3to0.5μmwideand1.0to1.7μmlong).B.quintanahasacircularchromosome(≈1.6Mb)recognisedasagenomicderivativeofBartonellahenselae,thecausativeagentofcatscratchdisease[1].Clinicalfeaturesandsequelae Theincubationperiodisusuallybetween15and25daysbuthasbeenreportedasshorter,uptosixdays,underexperimentalconditions[2].ClinicalmanifestationsofB.quintanainfectionincludetheclassicalrecurrentfever‘trenchfever’,chronicbacteraemia,endocarditisand,amongimmunocompromisedindividuals,bacillaryangiomatosis.Lymphadenopathyandocularcomplicationsareoccasionallyreported.Trenchfeverorquintanafever(5-dayfever)isarecurrentfeveramongn

Bartonella quintana is a species of Bartonella, which historically caused "trench fever", but more recently has been associated with a variety of ...

Bartonella quintana, a pathogen that is restricted to human hosts and louse vectors, was first characterized as the agent of trench fever. The disease was ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListEmergInfectDisv.12(2);2006FebPMC3373112EmergInfectDis.2006Feb;12(2):217–223.doi: 10.3201/eid1202.050874PMCID:PMC3373112PMID:16494745BartonellaquintanaCharacteristicsandClinicalManagementCédricFoucault,*PhilippeBrouqui,*andDidierRaoult*CédricFoucault*UniversitédelaMéditerranée,Marseille,FranceFindarticlesbyCédricFoucaultPhilippeBrouqui*UniversitédelaMéditerranée,Marseille,FranceFindarticlesbyPhilippeBrouquiDidierRaoult*UniversitédelaMéditerranée,Marseille,FranceFindarticlesbyDidierRaoultAuthorinformationCopyrightandLicenseinformationDisclaimer*UniversitédelaMéditerranée,Marseille,FranceCorrespondingauthor.Addressforcorrespondence:DidierRaoult,UnitédesRickettsiesCNRSUMR6020,FacultédeMédecine,UniversitédelaMéditerranée,27BdJeanMoulin,13385Marseille,CEDEX05,France;fax:33-4-91-83-03-90;email:rf.srm-vinu.enicedem@tluoar.reididCopyrightnoticeThisarticlehasbeencitedbyotherarticlesinPMC.Bartonellaquintana,apathogenthatisrestrictedtohumanhostsandlousevectors,wasfirstcharacterizedastheagentoftrenchfever.Thediseasewasdescribedin1915onthebasisofnaturalandexperimentalinfectionsinsoldiers.ItisnowrecognizedasareemergingpathogenamonghomelesspopulationsincitiesintheUnitedStatesandEuropeandisresponsibleforawidespectrumofconditions,includingchronicbacteremia,endocarditis,andbacillaryangiomatosis.Diagnosisisbasedonserologicanalysis,culture,andmolecularbiology.Recentcharacterizationofitsgenomeallowedthedevelopmentofmoderndiagnosisandtypingmethods.GuidelinesforthetreatmentofB.quintanainfectionsarepresented.Keywords:Bartonellaquintana,trenchfever,homeless,endocarditis,bacteremia,bacillaryangiomatosis,diagnosis,treatmentTrenchfever,thefirstclinicalmanifestationattributedtoBartonellaquintana,affectedanestimated>1millionpeopleduringW

Bartonella quintana, originally known as Rochalimaea quintana, and "Rickettsia quintana", is a bacterium transmitted by the human body louse that causes ...BartonellaquintanaFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchSpeciesofbacteriumBartonellaquintanaScientificclassificationDomain:BacteriaPhylum:ProteobacteriaClass:AlphaproteobacteriaOrder:HyphomicrobialesFamily:BartonellaceaeGenus:BartonellaSpecies:B. quintanaBinomialnameBartonellaquintana(Schmincke1917)Brenneretal.1993Synonyms[1]Rochalimaeaquintana(Schmincke1917)Krieg1961WolhyniaqintanaeZhdanovandKorenblit1950RickettsiawolhynicaJungmannandKuczynski1918RickettsiaweigliMosing1936RickettsiaquintanaSchmincke1917RickettsiapediculiMunkanddaRocha-Lima1917Burnetia(Rocha-limae)wolhynicaMacchiavello1947Bartonellaquintana,originallyknownasRochalimaeaquintana,[2]and"Rickettsiaquintana",[3]isabacteriumtransmittedbythehumanbodylousethatcausestrenchfever.[4]Thisbacterialspeciescausedoutbreaksoftrenchfeveraffecting1millionsoldiersinEuropeduringWorldWarI.[5]Contents1Genome2Backgroundandcharacteristics3Pathophysiology4Ecologyandepidemiology5Clinicalmanifestations6Diagnosisandtreatment7References8ExternallinksGenome[edit]B.quintanahadanestimatedgenomesizeof1,700to2,174kb.,[6]butthefirstgenomesequence(ofstrainRM-11)containsasinglecircularchromosomeof1,587,646basepairs.[7]Backgroundandcharacteristics[edit]B.quintanaisafastidious,aerobic,Gram-negative(-),polerod-shaped(bacillus)bacterium.Theinfectioncausedbythismicroorganism,trenchfever,wasfirstdocumentedinsoldiersduringWorldWarI,buthasnowbeenseenEurope,Asia,andNorthAfrica.ItsprimaryvectorisknowntobePediculushumanusvarietycorporis,alsoknownasthehumanbodylouse.[8]ItwasfirstknowntobeisolatedinaxenicculturebyJ.W.Vinsonin1960,fromapatientinMexicoCity.HethenfollowedKoch'spostulates,infectingvolunteerswiththebacterium,showingconsistentsymptomsandclinicalmanifestationsoftrenchfever.Themediumbestforgrowingthisbacteriumisblood-enrichedinanatmospherecontaining5%carbondioxide.