Cat scratch disease (CSD) is caused by Bartonella hensela e [1–3]. The pathogens are transmitted by bites or scratches from infected cats.SkiptomaincontentAdvertisementSearchallBMCarticlesSearchDownloadPDFCaseReportOpenAccessPublished:19March2014Acasereportofseronegativecatscratchdisease,emphasizingthehistopathologicpointofviewOkRanShin1,YangReeKim2,Tae-hyunBan2,TaeseokLim2,TaeHeeHan3,SuYeonKim4&KyungJinSeo1 DiagnosticPathologyvolume 9,Article number: 62(2014)Citethisarticle3567Accesses9Citations1AltmetricMetricsdetailsAbstractCatscratchdisease,necrotizinggranulomatouslymphadenitiscausedbyBartonellahenselae,usuallybenignandself-limited.However,variousclinicalmanifestationsandnopathognomonichistopathologicfeaturescanleadtomisinterpretationsanddiagnosticdisputes.Wereportacaseofcatscratchdiseaseina39-yr-oldmalepatientwithfeverandleftaxillarylymphadenitis.Hehadahistoryofcatbiteonthelefthanddorsum.Onexcision,thelymphnodeshowedfollicularhyperplasia,stellatemicroabscesseswitharimofgranulomatousinflammation.Warthin-Starrysilverstainingshowedmanyclumpsofsilver-stainedbacilliwithinthenecroticfoci.Serologicaltestswerenegative.DiagnosiswasestablishedbyPCRanalysis.VirtualslidesThevirtualslidesforthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/vs/1877499238123059LettertotheeditorCatscratchdisease(CSD)iscausedbyBartonellahenselae[1–3].Thepathogensaretransmittedbybitesorscratchesfrominfectedcats.Usuallyaunilaterallymphadenitisnearthescratch,bitesitedevelops2–3 weeksafterinfection.CSDisacommoncauseofchroniclymphnodeswellinginchildrenandadolescents[1–3].Histopathologically,theaffectedlymphnodeshowsgranulomawithmicroabscessformation,whichisnotpathognomonic.WepresentacaseofCSD,serologicallynegativebutpositivebyWarthin-Starry(WS)stainandconfirmedbyPCR,discusshistopathologicfeaturesandreviewtheliterature,emphasizinghistopathologicdifferentialdiagnosis.A39-year-oldmalepatientwasadmittedwithpainfulswellingintheleftaxillaandelbowandfeverfor3 weeks.Hehadahistoryofcatbite

CatScratchFeverMedicallyreviewedbyDanielMurrell,M.D.—WrittenbytheHealthlineEditorialTeam—UpdatedonFebruary1,2019CausesRiskfactorsSymptomsincatsSymptomsinhumansPicturesDiagnosisComplicationsTreatmentPreventionWhentocallyourdoctorOutlookWhatiscatscratchfever?Catscratchfever,alsocalledcatscratchdisease(CSD),isabacterialinfection.ThediseasegetsitsnamebecausepeoplecontractitfromcatsinfectedwithBartonellahenselaebacteria.TheCentersforDiseaseControlandPrevention(CDC)estimatesthat12,000peoplewillbediagnosedwithcatscratchfever,and500peoplewillbehospitalizedeachyearintheUnitedStates.CasessurgebothinJanuary—possiblyduetoincreasedadoptionsofkittens—andintheperiodbetweenAugustandNovember.Whatcausescatscratchfever?Youcangetcatscratchfeverfromabiteorscratchfromaninfectedcat.Youcanalsogetthediseaseifsalivafromaninfectedcatgetsintoanopenwoundortouchesthewhitesofyoureyes.Occasionally,youmaygetthediseasefromafleaoratickcarryingthebacterium.Youcan’tgetcatscratchdiseasefromanotherhuman.Whoisatriskforcatscratchfever?Anyonewhoownsorinteractswithacatisatriskofcontractingcatscratchfever.TheCDCreportsthatcatscratchfeverismostprevalentinthesouthernpartoftheUnitedStatesandmostcommonamongchildrenbetweentheagesof5and9yearsold.Peoplewhowerehospitalizedweremorelikelythanoutpatientstobemale,thoughthemajorityofpeoplewhoarediagnosedarefemale.Youhaveanincreasedriskofbecomingseriouslyillfromcatscratchfeverifyouhaveaweakenedimmunesystem.Peoplewhomightfallintothiscategoryincludethosewhoarepregnantorwhoarelivingwith:cancerdiabetesHIVorAIDStransplantedorgansWhatarethesymptomsofcatscratchfeverincats?CatscancarryB.henselae,buttheydon’tgenerallygetsickfromthebacteria.Forthisreason,youcan’talwaystellifthey’recarriers.Catslikelycontractthebacteriafrominfectedfleas.Inveryrareinstances,humanscancontractthebacteriadirectlyfromfleas.AccordingtotheCDC,around40percentofcatscarrythebacteriaatsometimeintheirlives,mostcommonlyaskittens.Treatmentforcatsisn’tusuallyrecommended.Whatarethesymptomsofcatscratchfeverinhumans?C

Cat scratch disease. H&E stain. LM, necrotizing granulomas with neutrophils and star-shaped (stellate), +/-multinucleated giant cells, microorganisms consistent ...CatscratchdiseaseFromLibrePathologyJumptonavigationJumptosearchCatscratchdiseaseDiagnosisinshortCatscratchdisease.H&Estain.LMnecrotizinggranulomaswithneutrophilsandstar-shaped(stellate),+/-multinucleatedgiantcells,microorganismsconsistentwithB.henselaeLMDDxsporotrichosis,lymphogranulomavenereum,tularemiaStainsWarthin-Starrystain+veIHCB.henselae+veSitelymphnode-seelymphnodepathologyClinicalhistorycontactwithcatsSignsfever,lymphadenopathyPrevalencerarePrognosisbenignClin.DDxothercausesoflymphadenopathy,e.g.lymphomaCatscratchdisease,alsocatscratchfever,isanuncommonpathologyofthelymphnode.Contents1General1.1Clinical2Gross3Micrograph3.1Images4Stains5IHC6Seealso7ReferencesGeneralInfectioncausedBartonellahenselae,[1]agram-negativebacillus(0.3-1.0x0.6-3.0micrometers)inchains,clumps,orsingular.[2]Treatment:antibiotics.ClinicalFeatures:[3]Usuallyunilaterallymphadenopathy.Maybedisseminatedinindividualswithimmunedysfunction.Contactwithcats.GrossLymphadenopathy-usu.unlitateral.Typicallyaxillaryorcervical(liketularemia).[4]MicrographFeatures:[3]Necrotizinggranulomaswith:Neutrophilspresentinmicroabscess(necroticdebris)-keyfeature.Microabscessesoftendescribedas"stellate"(star-shaped).+/-Multinucleatedgiantcells.MicroorganismconsistentwithB.henselae.Notes:Mayinvolvecapsuleorperinodaltissue.DDxofstellateabscessinlymphnodes-catsplit:[5]Cat-scratchdisease.Sporotrichosis.Lymphogranulomavenereum.Tularemia.Imageswww:Cat-scratchdisease(webpathology.com).Cat-scratchdisease-highmag.(webpathology.com)CSD-verylowmag.-showingserpentineshapedmicroabscesses(WC)CSD-lowmag.-showingserpentineshapedmicroabscesses(WC)CSD-highmag.-showingneutrophilicabscesses(WC)StainsWarthin-Starrystain+ve--bacilli.Gramstain-ve.IHCB.henselaeIHCstain+ve--bacilli-diagnostic.SeealsoLymphnodepathology.References↑Jerris,RC.;Regnery,RL.(1996)."Willtherealagentofc

ScrollToTopAboutNewsEventsContactPODCASTStoredonateMenuforPatientsandFamiliesInformation&ResourcesRareDiseaseInformationRareDiseaseVideoLibraryPatientandCaregiverResourceCenterInformationonClinicalTrialsandResearchStudiesCOVID-19ResourcesHelptoAccessMedicationsPatientAssistanceProgramsOtherFinancialAssistanceConnectwithOthersFindaPatientOrganizationRareDiseaseDay®PatientStoriesTakeActionAttendEventsAdvocateSupportCloseforPatientOrganizationsJoinMembershipNetworkValueofMembershipMembershipCriteriaApplyforMembershipNonprofitResourcesMemberResourcesRareLaunch®WebinarSeriesCOVID-19RapidResponseLeadershipSeriesOtherWaystoPartnerGrowyourorganizationPatientRegistriesAdvocacyRareDiseaseDay®RDCA-DAP®MembershipProfilesAboutourMembersMemberListRareCancerCoalitionCloseforCliniciansandResearchersResourcesResourcesforMedicalProfessionalsRareDiseaseInformationResourcesforyourPatientsContinuingMedicalEducationResearchOpportunitiesResearchGrantProgramRequestsforProposalsResearchGrantRecipientsConnectLendYourExpertiseRareDiseaseDay®CloseNORDRareDiseaseAdvocacyNORD’sPolicyinActionIssueOverviewsNORDontheIssuesPolicySteeringCommitteeNORDStateReportCardNationalPartnershipsTakeActionLocallyJointheRareActionNetwork®ProjectRDACContactYourRepresentativesTakeActionRareInsights®RareInsights®5MythsAboutOrphanDrugsandtheOrphanDrugActCloseGetInvolvedDonateNowGiveWaystoGiveDonatetoResearchNORD®StoreEducateEducationalInitiativesRaiseAwarenessIdentifyRareDiseaseExpertsJoinParticipateinEventsBecomeaMemberRareCancerCoalitionEmploymentOpportunitiesCorporateCouncilAbouttheCorporateCouncilCurrentMembersCouncilCodeofConductJointheCouncilCloseHome/ForPatientsandFamilies/RareDiseaseInformation/BartonellosisRareDiseaseDatabase0-9•A•B•C•D•E•F•G•H•I•J•K•L•M•N•O•P•Q•R•S•T•U•V•W•X•Y•ZPrintBartonellosisNORDgratefullyacknowledgesChristinaNelson,MD,MPH,MedicalEpidemiologist,DivisionofVector-borneDiseases,CentersforDiseaseControlandPrevention,forassistanceinthepreparationofthisreport.SubdivisionsofBartonellosisCarri

Pathophysiology. The clinical hallmark is lymphadenopathy at the site of inoculation. In the immunocompetent host, a granulomatous ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermCatScratchDiseaseKatherineBaranowski;BenHuang.AuthorInformationAuthorsKatherineBaranowski1;BenHuang2.Affiliations1RutgersHealthSciencesUniversity2MarianUnCollegeofOsteopathicMedLastUpdate:June23,2020.ContinuingEducationActivityCatscratchdiseaseisanillnesscausedbyanintracellulargram-negativerodknownasBartonellahenselae.Itaffectsthelymphnodesdrainingtheareawhereacatscratchorbiteoccurscausingregionallymphadenopathy.Thisactivityillustratestheevaluationandtreatmentofcatscratchdiseaseandexplainstheroleoftheinterprofessionalteaminmanagingpatientswiththiscondition.Objectives:IdentifyBartonellahenselaeastheetiologicagentincatscratchdisease.Describethepathophysiologyofcatscratchdisease.Reviewtheuseofantibioticsinmildtomoderatediseaseandthedisseminatedformofcatscratchdisease.Explaintheimportanceofcollaborationandcommunicationamongtheinterprofessionalteammemberstoenhancedeliveryofcareforpatientsaffectedbycatscratchdisease.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionCatScratchdisease(CatScratchFever)causesafebrileillnesswithsubacuteregionallymphadenopathy.TheagentofinfectionisBartonellahenselae.Inmostcases,thereisaspontaneousresolutionwithin2to4weeks.Moresevereanddisseminateddiseasecanoccurinbothimmunocompetentandimmunocompromisedhosts.CatScratchdiseasewasinitiallydescribedinthe1930s,andtheassociationoftheillnesswithcatswasidentifiedinthe1950s.Catscratchshouldbeconsideredinthedifferentialdiagnosisofanyacute,subacuteorchroniclymphadenopathy.[1][2][3]EtiologyTheprincipaletiologicagentofcat scratchdisea

Cat-scratch disease (CSD) is largely due to infection with Bartonella henselae. ... American Journal of Clinical Pathology, Volume 131, Issue 2, ...SkiptoMainContentAdvertisementSearchMenuAccountMenuMenuSignInRegisterNavbarSearchFilterThisissueAllAmericanJournalofClinicalPathologyAllASCPJournalsAllJournalsMobileMicrositeSearchTermSearchSignInRegisterIssuesMoreContentAdvancearticlesCOVID-19articlesEditor'sChoiceCME/SAMArticlesSubmitAuthorGuidelinesOpenAccessSubmissionSitePurchaseAdvertiseAdvertisingandCorporateServicesAdvertisingMediakitReprintsandePrintsSponsoredSupplementsBrandedBooksAboutAboutAmericanJournalofClinicalPathologyAbouttheAmericanSocietyforClinicalPathologyEditorialBoardAlertsSelf-ArchivingPolicyIssuesMoreContentAdvancearticlesCOVID-19articlesEditor'sChoiceCME/SAMArticlesSubmitAuthorGuidelinesOpenAccessSubmissionSitePurchaseAdvertiseAdvertisingandCorporateServicesAdvertisingMediakitReprintsandePrintsSponsoredSupplementsBrandedBooksAboutAboutAmericanJournalofClinicalPathologyAbouttheAmericanSocietyforClinicalPathologyEditorialBoardAlertsSelf-ArchivingPolicyClosesearchfilterThisissueAllAmericanJournalofClinicalPathologyAllASCPJournalsAllJournalssearchinputSearchAdvancedSearchSearchMenuSkipNavDestinationArticleNavigationClosemobilesearchnavigationArticleNavigationVolume131Issue2February2009ArticleContentsAbstractMaterialsandMethodsResultsDiscussionReferencesArticleNavigationEvaluationofImmunohistochemistryinIdentifyingBartonellahenselaeinCat-ScratchDiseaseGabrielC.Caponetti,MD,GabrielC.Caponetti,MD1DepartmentsofPathology,BaystateMedicalCenter,TuftsUniversitySchoolofMedicine,Springfield,MAandSearchforotherworksbythisauthoron:OxfordAcademicGoogleScholarLironPantanowitz,MD,LironPantanowitz,MD1DepartmentsofPathology,BaystateMedicalCenter,TuftsUniversitySchoolofMedicine,Springfield,MAandSearchforotherworksbythisauthoron:OxfordAcademicGoogleScholarSharonMarconi,SharonMarconi1DepartmentsofPathology,BaystateMedicalCenter,TuftsUniversitySchoolofMedic

NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListCalifMedv.82(1);1955JanPMC1532251CalifMed.1955Jan;82(1):25–31.PMCID:PMC1532251PMID:13230912PATHOLOGYOFCAT-SCRATCHDISEASEPaulH.GuttmanCopyrightandLicenseinformationDisclaimerCopyrightnoticeThisarticlehasbeencitedbyotherarticlesinPMC.AbstractApathologicandhistogeneticstudyofmaterialobtainedfromtencasesofcat-scratchdiseasewascarriedout.Theearliestlesionwasoftendays'durationandtheoldestof35days'duration.Thefirstchangesinlymphnodesconsistedofproliferationofepithelioidcellsfollowedbyexudationofleukocytesintheircentersandsubsequentnecrosisoftheexudateandepithelioidcells.Proliferativechangesleadingtoformationofepithelioidcelltubercleswereseeninsomecases.Homogenizationofnecroticcentersbroughtabouttheformationofcaseoustuberclessimilartothoseseenintuberculosis,syphilis,lymphogranulomavenereumandtularemia.Differentiationandthefinaldiagnosisofcat-scratchdiseaserestsuponcorrelationofhistopathologicobservations,clinicalstudiesandspecificskintests.FulltextFulltextisavailableasascannedcopyoftheoriginalprintversion.Getaprintablecopy(PDFfile)ofthecompletearticle(1.8M),orclickonapageimagebelowtobrowsepagebypage.LinkstoPubMedarealsoavailableforSelectedReferences. 25262728293031 ImagesinthisarticleFigure1.onp.27Figure2.onp.27Figure3.onp.28Figure4.onp.28Clickontheimagetoseealargerversion.SelectedReferencesThesereferencesareinPubMed.Thismaynotbethecompletelistofreferencesfromthisarticle.CASSADYJV,CULBERTSONCS.Cat-scratchdiseaseandParinaud'soculoglandularsyndrome.AMAArchOphthalmol.1953Jul;50(1):68–74.[PubMed][GoogleScholar]DAESCHNERCW,SALMONGW,HEYSFM.Cat-scratchfever.JPediatr.1953Oct;43(4):371–384.[PubMed][GoogleScholar]DANIELSWB,MACMURRAYFG.Catscratchdisease;nonbacterialregionallymphadenitis:areportof60cases.AnnInternMed.1952Oct;37(4):697–713.[PubMed][GoogleScholar]DANIELSWB,MacMURRAYFG.Catscratchdisease;non-bacterialregionallymphadenitis.TransAssocAmPhysicians.1951;64:137–146.[PubMed]

Cat-Scratch Disease ... Comments: Cat-scratch disease usually presents with a skin lesion (7 to 12 days after contact) and enlargement of regional lymph nodes.Followus:        11085Images:LastWebsiteUpdate:Jun9,2021Cat-ScratchDiseaseHighQualityPathologyImagesofLymphNode/Spleen,LymphNode,LymphadenitidesHomeSlidesSlideIndexSlideIndexCategoriesNeuropathGlialTumorsNon-GlialTumorsNon-NeoplasticBreastBenignProlif.LesionsBreastCarcinomasRareBreastTumorsInflammatory/ReactiveHead&NeckOralCavity,Oropharynx&NeckMaxillofacialSalivaryGlandsNose&SinusesLarynxEarEyeMediastinumMediastinumPeritoneumPeritoneum,Omentum&MesenteryGenitourinaryProstateUrinaryBladderKidneyTestisExternalGenitaliaAdrenalLymphNode/SpleenLymphNodeSpleenHematopathologyMatureB-cellNeoplasms-PartIMatureB-cellNeoplasms-PartIIMatureT-cell&NK-cellNeoplasmsMyeloid,Histiocytic&DendriticCellNeoplasmsLymphNode,Spleen&BoneMarrowGynecologicVulva/VaginaCervixUterusOvaryPlacenta&TrophoblasticLesionsOrthopedicBoneTumors-IBoneTumors-IITumor-likeLesionsofBoneMisc.BoneLesionsLesionsofJointsEndocrineThyroidParathyroidPancreasAdrenalPituitaryDermPathProliferations&NeoplasmsNon-NeoplasticDermPath-INon-NeoplasticDermPath-IIGastrointestinalEsophagusStomachSmallBowelAppendixLargeBowelAnusLiverGallbladderPancreasSoftTissueFibrousTissueFibrohistiocyticLipomatousMyogenicVascular&LymphaticPeripheralNerveUncertainHistogenesisMisc.SoftTissueLesionsPulmonaryLung-Non-NeoplasticEpithelialLungTumors(2015WHOClassification)MesenchymalTumorsofLungPleuraMiscellaneousLungTumorsCardiovascularHeartBloodVesselsInfectiousDiseaseSpecificClinicalSyndromesBacteria-IBacteria-IIBacteria-IIIFungalOrganismsVirusesParasitesPediatricPediatricPathology-IPediatricPathology-IICytopathologyCytopathologyICytopathologyIIGeneticDisordersAboutAcknowledgementsFeedbackContactAdvertisementCat-ScratchDiseaseHomeLymphNode/SpleenLymphNodeLymphadenitidesCat-ScratchDiseaseslide1of20Comments:Cat-scratchdiseaseusuallypresentswithaskinlesion(7to12daysaftercontact)andenlargemento

Cite this page: DePond WD. Cat scratch disease. PathologyOutlines.com website​. https://www.pathologyoutlines.com/topic/lymphnodescatscratch ...AuthorsBlogBoardReviewCommentContactUsNewslettersStatisticsTestimonialsCDmarkersisnowpartoftheStainschapter;newMolecularmarkerschapterJobsFellowshipsConferences/WebinarsBooksCMECasesAdvertiseGrantsMedicalNewsLibrariesRocheCompanionDiagnosticLibraryRocheNTRKIHCDiagnosticLibraryCOVID-19LibraryPandemicreliefmusicawardHome>Lymphnodes&spleen,nonlymphoma>CatscratchdiseaseLymphnodes&spleen,nonlymphomaLymphnodes-infectious/parasiticdisordersCatscratchdiseaseAuthor: WilliamD.DePond,M.D.TopicCompleted:1July2013Minorchanges:27May2021Copyright:2003-2021,PathologyOutlines.com,Inc.PubMedSearch:Cat-scratchdisease[title]lymphnodesPageviewsin2020:13,009Pageviewsin2021todate:7,464TableofContentsDefinition/general|Historicalcriteria|Casereports|Gramstain|Diagnosis|Grossimages|Microscopic(histologic)description|Microscopic(histologic)images|Positivestains|Electronmicroscopydescription|Differentialdiagnosis|AdditionalreferencesCitethispage:DePondWD.Catscratchdisease.PathologyOutlines.comwebsite.https://www.pathologyoutlines.com/topic/lymphnodescatscratch.html.AccessedJune13th,2021.Definition/generalCausedbyBartonella(formerlyRochalimaea)henselae(AmJClinPathol1994;101:607),harboredbykittensandyoungcats;transmittedbetweencatsbycatflea(butnotfromcatstohumans)Adultsorchildren(85%underage18)infectedbycatclawscontaminatedwithinfectedfleafeces;24Kcases/yearinUS(mostcommoncauseofchronicbenignlymphadenopathy)Cutaneousredpapule7-12daysaftercontactthatmaybecomecrustedorpustular,withenlargementofcervicaloraxillarynodesMayhavenecrotizinggranulomasinliver,spleenorboneUsuallyresolvesspontaneously;erythromycinorothermacrolidesmaybegivenRarecomplicationsaregranulomatousconjunctivitis,thrombocytopenicpurpura,CNSdisease(EurJInternMed2005;16:610)HistoricalcriteriaExposuretocatandpresenceofscratchordermal/eyelesionPositivecatscratchdiseaseantigenskintestRegionallymp

LymphoreticularandHematopoeticInfectionsReturntosyllabusCAT-SCRATCHFEVERGeneralGoal:Toknowthemajorcause(s)ofthisdisease,howitistransmitted,andthemajormanifestationsofthedisease.SpecificEducationalObjectives:Thestudentshouldbeableto:1.recitethemostcommoncausesofcat-scratchfever(shapeandgramstain?).2.describethecommonmeansoftransmission.3.describethemajormanifestationsofthisinfection.4.describehowyoudiagnose,treatandpreventthisinfection.Reading:MEDICALMICROBIOLOGYbyP.R.Murray,K.S.Rosenthal,G.S.KobayashiandM.A.Pfaller,3rdEdition.pp.287.Lecture:Dr.NealR.ChamberlainReferences: 1.eMedicine:CatScratchFever,JosephRLex,Jr,MD,ConsultingStaff,DepartmentofEmergencyMedicine,ChestnutHillHospital.http://www.emedicine.com/cgi-bin/foxweb.exe/showsection@d:/em/ga?book=emerg&topicid=842.ChomelBB,AbbottRC,KastenRW,Floyd-HawkinsKA,KassPH,GlaserCA,PedersenNC,KoehlerJE.1995.BartonellahenselaeprevalenceindomesticcatsinCalifornia:riskfactorsandassociationbetweenbacteremiaandantibodytiters.JClinMicrobiolSep;33(9):2445-503.BassJW,FreitasBC,FreitasAD,etal.Prospectiverandomizeddoubleblindplacebo-controlledevaluationofazithromycinfortreatmentofcat-scratchdisease.PediatrInfectDisJ.1998;17:447-452.4.JaredM.Frandson,MPH,JulieRawlings,MPH,ChristineR.Burgess,MPH,KateA.Hendricks,MD,MPH&TM;TexasDepartmentofHealth,Austin.Cat-ScratchDiseaseinTexas.2000.InfectMed17(10):690-694.http://id.medscape.com/SCP/IIM/2000/v17.n10/m1710.03.fran/pnt-m1710.03.fran.html5.JacomoV,PJKelly,andDRaoult,NaturalHistoryofBartonellaInfections(anExceptiontoKoch'sPostulate),2002.ClinDiagLabImmun,9:8-18.http://cdli.asm.org/cgi/content/full/9/1/8?view=full&pmid=11777823OverviewCat-scratchdiseaseisaslowlyprogressive,self-limiting,chroniclymphadenopathythatusuallyoccursinchildren.Cat-scratchdisease,asitsnameimplies,istransmittedtohumansbythescratchorbiteofacatthathasBartonellahenselaeinitssalivaandonitsnails.EtiologyBartonellahenselaeisarod-shapedgram-negativeorganismthatcausescat-scratchdisease.ManifestationsBhenselaecancauseseveral