Cat scratch disease. H&E stain. LM, necrotizing granulomas with neutrophils and star-shaped (stellate), +/-multinucleated giant cells, microorganisms consistent ...CatscratchdiseaseFromLibrePathologyJumptonavigationJumptosearchCatscratchdiseaseDiagnosisinshortCatscratchdisease.H&Estain.LMnecrotizinggranulomaswithneutrophilsandstar-shaped(stellate),+/-multinucleatedgiantcells,microorganismsconsistentwithB.henselaeLMDDxsporotrichosis,lymphogranulomavenereum,tularemiaStainsWarthin-Starrystain+veIHCB.henselae+veSitelymphnode-seelymphnodepathologyClinicalhistorycontactwithcatsSignsfever,lymphadenopathyPrevalencerarePrognosisbenignClin.DDxothercausesoflymphadenopathy,e.g.lymphomaCatscratchdisease,alsocatscratchfever,isanuncommonpathologyofthelymphnode.Contents1General1.1Clinical2Gross3Micrograph3.1Images4Stains5IHC6Seealso7ReferencesGeneralInfectioncausedBartonellahenselae,[1]agram-negativebacillus(0.3-1.0x0.6-3.0micrometers)inchains,clumps,orsingular.[2]Treatment:antibiotics.ClinicalFeatures:[3]Usuallyunilaterallymphadenopathy.Maybedisseminatedinindividualswithimmunedysfunction.Contactwithcats.GrossLymphadenopathy-usu.unlitateral.Typicallyaxillaryorcervical(liketularemia).[4]MicrographFeatures:[3]Necrotizinggranulomaswith:Neutrophilspresentinmicroabscess(necroticdebris)-keyfeature.Microabscessesoftendescribedas"stellate"(star-shaped).+/-Multinucleatedgiantcells.MicroorganismconsistentwithB.henselae.Notes:Mayinvolvecapsuleorperinodaltissue.DDxofstellateabscessinlymphnodes-catsplit:[5]Cat-scratchdisease.Sporotrichosis.Lymphogranulomavenereum.Tularemia.Imageswww:Cat-scratchdisease(webpathology.com).Cat-scratchdisease-highmag.(webpathology.com)CSD-verylowmag.-showingserpentineshapedmicroabscesses(WC)CSD-lowmag.-showingserpentineshapedmicroabscesses(WC)CSD-highmag.-showingneutrophilicabscesses(WC)StainsWarthin-Starrystain+ve--bacilli.Gramstain-ve.IHCB.henselaeIHCstain+ve--bacilli-diagnostic.SeealsoLymphnodepathology.References↑Jerris,RC.;Regnery,RL.(1996)."Willtherealagentofc