Hydatidiform mole is an abnormal pregnancy characterized by varying degrees of trophoblastic proliferation (both cytotrophoblast and ...SpotlightNoninvasivePrenatalTestingAddressingtheCervicalCancerScreeningDisparitiesGapAdvancesintheTestingforPretermPrematureRuptureofMembraneBetterForWomenSeriesCervicalCancer&Co-TestingCervicalCancerScreening:ProtectingandImprovingHealthOutcomesofWomenCervicalCancerTodayCombinationRegimenofEstradiolandProgesteroneEndometriosisEnhancedRecoveryforCesareanDeliveriesintheUnitedStates:PerspectivesFromtheFrontLines–Part1LARCProviderToolkitLong-Lasting,ReversibleContraceptionManagementofUterineFibroidsMenopauseUterineFibroidClinicalSeeAll>ContraceptionCOVID-19GynecologyLegallySpeakingLifeTransitionsObstetricsVulvovaginalWellWomanAdvertiseContactUsJobBoardEditorialTermsofUsePrivacyPolicyDoNotSellMyPersonalInformation©2021MJHLifeSciences™andContemporaryOB/GYN.Allrightsreserved.Hydatidiformmole:RecognitionandmanagementMarch13,2019JohnR.Lurain,MDJohnR.Lurain,MDContemporaryOB/GYNJournal,Vol.64No03,Volume64,Issue03Molarpregnanciesmaybeassociatedwithseriousmorbiditysopromptdiagnosis,appropriatemanagement,andfollow-upareessential.Hydatidiformmoleisanabnormalpregnancycharacterizedbyvaryingdegreesoftrophoblasticproliferation(bothcytotrophoblastandsyncytiotrophoblast)andvesicularswellingofplacentalvilliassociatedwithanabsentorabnormalfetus/embryo.Twotypesofhydatidiformmole,completeandpartial,havebeendescribedbasedonbothmorphologicandcytogeneticcriteria(Table1).1,2 EpidemiologyEpidemiologicstudieshavereportedwideregionalvariationsintheincidenceofmolarpregnancies.EstimatesfromstudiesinNorthAmerica,Europe,AustraliaandNewZealandhaveshownincidenceratesrangingfrom0.57-1.1per1000pregnancies,whereasstudiesinSoutheastAsiaandJapanhavesuggestedanincidencerateashighas2.0per1000pregnancies.Thesereporteddifferencesmayberelatedtolackofstandardizationofdatacollectionandreportingratherthantrueincidencedifferences.However,socioeconomicstatusanddietratherthangeneticor

A hydatiform mole (also known as a molar pregnancy) is a gestational trophoblastic disease (GTD), which originates from the placenta and can ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutNCBIBookshelf.AserviceoftheNationalLibraryofMedicine,NationalInstitutesofHealth.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2021Jan-.StatPearls[Internet].ShowdetailsTreasureIsland(FL):StatPearlsPublishing;2021Jan-.SearchtermHydatidiformMoleSassanGhassemzadeh;MichaelKang.AuthorInformationAuthorsSassanGhassemzadeh1;MichaelKang2.Affiliations1RiversideCommHosp,UCRiverside2UniversityofCaliforniaRiversideSchoolofMedicineLastUpdate:January16,2021.ContinuingEducationActivityAhydatiformmole(alsoknownasamolarpregnancy)isagestationaltrophoblasticdisease(GTD),whichoriginatesfromtheplacentaandcanmetastasize.Itisuniqueinthatthetumororiginatesfromgestationaltissueratherthanfrommaternaltissue.Hydatiformmoles(HM)arecategorizedascompleteandpartialandareusuallyconsideredthenoninvasiveformofgestationaltrophoblasticdisease.Whilehydatiformmolesaretypicallydeemedbenign,theyarepremalignantanddohavethepotentialtobecomemalignantandinvasive.Thisactivitydescribesthepathophysiology,evaluation,andmanagementofhydatiformmolesandhighlightstheroleoftheinterprofessionalteaminthemanagementofaffectedpatients.Objectives:Identifytheetiologyofahydatiformmole.Describethepresentationofapatientwithahydatiformmole.Reviewthetreatmentandmanagementoptionsavailableforhydatiformmoles.Explaininterprofessionalteamstrategiesforimprovingcarecoordinationandcommunicationtoadvancethetreatmentofhydatiformmolesandimproveoutcomes.Earncontinuingeducationcredits(CME/CE)onthistopic.IntroductionHydatiformmole(alsoknownasmolarpregnancy)isasubcategoryofdiseasesundergestationaltrophoblasticdisease(GTD),whichoriginatesfromtheplacentaandcanmetastasize.Itisuniquebecausethetumororiginatesfromgestationaltissueratherthanfrommaternaltissue.Otherformsof gestationaltrophoblasticdisease in

A hydatidiform mole is sometimes detected when you have an early pregnancy ultrasound. It may also be diagnosed after a miscarriage, when the tissue that is ...SkiptomaincontentSitesearchSearchthewebsiteSearchCloseSearchBreadcrumbs:HomeHealthinformationPregnancy&birthPregnancyproblemsEarlypregnancyproblemsHydatidiformmoleHydatidiformmoleBleedinginearlypregnancyMiscarriageTreatingmiscarriageEctopicpregnancyHydatidiformmoleAhydatidiformmoleormolarpregnancyisveryuncommonaffectingaround1in1,200pregnancies.Itisusuallyfoundinearlypregnancy. Ahydatidiformmoleissometimesdetectedwhenyouhaveanearlypregnancyultrasound.Itmayalsobediagnosedafteramiscarriage,whenthetissuethatiscollectedorpassedfromtheuterusisexamined.Astheconditionisunusualandnotwellknowninthecommunity,itcancomeasashock,especiallyifyouarestillpregnantandcomingtotermswiththefactthatthepregnancyisending. Onthispage:Whatisamolarpregnancy?RelatedproblemsWhydidIdevelpamolarpregnancy?GestationalTrophoblasticDisease(GTD)RegistryWhencanIgetpregnantagain?Whatarethechangesofamolarpregnancyinthefuture?EmotionsandsupportWhatisamolarpregnancy?Inamolarpregnancy thereisunusualandrapidgrowthofpartoralloftheplacenta.Theplacentabecomeslargerthannormalandcontainsanumberofcysts(sacsoffluid). Thefirstpartofthename'hydatidiform' comesfromtheGreekword'hydatid' meaningdroplet.Thesedropletsappeartoburrowintothewalloftheuterus,hencethenamemole. Inacompletemolarpregnancy,thegrowthstopsafetusfromdeveloping.Inapartialmolarpregnancy,afetusdevelopsbutitwillbeabnormalandcannotsurvive. Atmost,thefetusmightsurviveforaroundthreemonths.Inamolarpregnancy,youwillhavealltheusualsignsofpregnancy(likemorningsicknessorsorebreasts)becausetheplacentacontinuestomakethepregnancyhormonehCG.Infact,theplacentaoftenmakeshigheramountsofthishormonethanitwouldnormally.Mostofthetime,amolarpregnancyisdiscoveredinthefirstthreemonthsofpregnancy,oftenbecauseitendsinamiscarriage.ReturntotopRelatedproblemsInsomecasestheplacentacanbecomemalignantandarareformofcancer,called

Hydatidiform mole (HM) is one of a group of diseases that develop from abnormal proliferation of trophoblast and are classified as gestational ...

A hydatidiform mole is considered malignant if metastases or destructive invasion of the myometrium (ie, invasive mole) occurs, or when the ...ForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoEdition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSLogInSignUpIt'sFree!Edition:ENGLISHDEUTSCHESPAÑOLFRANÇAISPORTUGUÊSRegisterLogInNoResultsNoResultsForYouNews&PerspectiveDrugs&DiseasesCME&EducationAcademyVideoclosePleaseconfirmthatyouwouldliketologoutofMedscape.Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit.LogoutCancelhttps://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU0NjU3LW92ZXJ2aWV3processing....Drugs&Diseases>Obstetrics&GynecologyHydatidiformMoleUpdated:Feb16,2018Author:LisaEMoore,MD,MS,FACOG,RDMS;ChiefEditor:WarnerKHuh,MD more...ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInGoogle+SectionsHydatidiformMoleSectionsHydatidiformMoleOverviewBackgroundPathophysiologyEpidemiologyPrognosisPatientEducationShowAllPresentationHistoryPhysicalExaminationShowAllDDxWorkupLaboratoryStudiesImagingStudiesHistologicFindingsShowAllTreatmentMedicalCareSurgicalCareLong-TermMonitoringShowAllMedicationQuestions&AnswersMediaGalleryReferencesOverviewBackgroundGestationaltrophoblasticdiseaseencompassesseveraldiseaseprocessesthatoriginateintheplacenta.Theseincludecompleteandpartialmoles,placentalsitetrophoblastictumors,choriocarcinomas,andinvasivemoles. Adietdeficientinanimalfatandcarotenemaybeariskfactor.[1] Morerecently,JapaneseinvestigatorshaveidentifiedanovelhomozygousnonsensemutationintheNLRP7gene (c.584G>A;p.W195X)inapatient thatappearstoassociatedwithrecurrenthydatidiformmole.[2]Theyalsonotedthatthemolewasbiparental,andtherewasaspecificmaternallossofDNAmethylationof differentiallymethylatedregions(DMRs).[2]Almostallwomenwithmalignantgestationaltrophoblasticdiseasecanbecuredwithpreservationofreproductivefunction.Thefollowingdiscussionislimitedtohydatidifo

A molar pregnancy — also known as hydatidiform mole — is a rare complication of pregnancy characterized by the abnormal growth of ...Scheduleyourappointmentnowforsafein-personcare.Learnmore:MayoClinicfactsaboutcoronavirusdisease2019(COVID-19)Our COVID-19patient andvisitorguidelines,plustrustedhealthinformationLateston COVID-19vaccination bysite:ArizonapatientvaccinationupdatesArizona,FloridapatientvaccinationupdatesFlorida,RochesterpatientvaccinationupdatesRochesterandMayoClinicHealthSystempatientvaccinationupdatesMCHSSkiptositenavigationSkiptoContentThiscontentdoesnothaveanEnglishversion.ThiscontentdoesnothaveanArabicversion.SectionsforMolarpregnancySymptoms&causesDiagnosis&treatmentPrintOverviewAmolarpregnancy—alsoknownashydatidiformmole—isararecomplicationofpregnancycharacterizedbytheabnormalgrowthoftrophoblasts,thecellsthatnormallydevelopintotheplacenta.Therearetwotypesofmolarpregnancy,completemolarpregnancyandpartialmolarpregnancy.Inacompletemolarpregnancy,theplacentaltissueisabnormalandswollenandappearstoformfluid-filledcysts.There'salsonoformationoffetaltissue.Inapartialmolarpregnancy,theremaybenormalplacentaltissuealongwithabnormallyformingplacentaltissue.Theremayalsobeformationofafetus,butthefetusisnotabletosurvive,andisusuallymiscarriedearlyinthepregnancy.Amolarpregnancycanhaveseriouscomplications—includingarareformofcancer—andrequiresearlytreatment.Products&ServicesBook:MayoClinicGuidetoaHealthyPregnancySymptomsMolarpregnancyOpenpop-updialogboxCloseMolarpregnancyMolarpregnancyDuringamolarpregnancy,theplacentadevelopsintoanabnormalmassofcysts.Theembryoeitherdoesn'tformorismalformedandcan'tsurvive.Amolarpregnancymayseemlikeanormalpregnancyatfirst,butmostmolarpregnanciescausespecificsignsandsymptoms,including:DarkbrowntobrightredvaginalbleedingduringthefirsttrimesterSeverenauseaandvomitingSometimesvaginalpassageofgrapelikecystsPelvicpressureorpainIfyouexperienceanysignsorsymptomsofamolarpregnancy,consultyourdoctororpregnancycareprovider.Heorshemaydetectother

Hydatidiform Mole · Vaginal bleeding - The most common symptom of a complete mole is vaginal bleeding. · Hyperemesis - Patients may also complain of severe ...HydatidiformMoleINTRODUCTION　Background:Gestationaltrophoblasticdiseaseincludesseveraldiseaseprocessesthatoriginateintheplacenta.Thisincludescompleteandpartialmoles,placentalsitetrophoblastictumors,choriocarcinomasandinvasivemoles.Almostallwomenwithmalignantgestationaltrophoblasticdiseasecanbecuredwithpreservationofreproductivefunction.Thefollowingdiscussionwillbelimitedtohydatidiformmoles,completeandpartial.　Pathophysiology:Acompletemolecontainsnofetaltissue.90%are46XXand10%are46XY.Allchromosomesareofpaternalorigin.Anenucleateeggisfertilizedbyahaploidsperm,whichthenduplicatesitschromosomes,ortheeggisfertilizedby2sperm.Inacompletemolethechorionicvillihavegrapelike(hydatidiform)swelling,andthereistrophoblastichyperplasia.Withapartialmole,fetaltissueisoftenpresent.Thechromosomalcomplementis69XXXor69XXY.Thisresultsfromfertilizationofahaploidovumandduplicationofthepaternalhaploidchromosomes,orfromdispermy.Asinacompletemole,thereishyperplastictrophoblastictissueandswellingofthechorionicvilli.Frequency:　IntheUS:Inwesterncountries,1:1000-1:1500pregnanciesareaffected.Itisanincidentalfindinginapproximately1in600therapeuticabortions.Internationally:InAsiancountriestherateisasmuchas15timeshigherthanintheUS.Japanhasareportedrateof2per1000pregnancies.IntheFarEast,somesourcesestimatetherateashighas1:120pregnancies.Mortality/Morbidity:Ofpatientswithhydatidiformmole,20%willdevelopatrophoblasticmalignancy.Afteracompletemole,uterineinvasionoccursin15%ofpatients,andmetastasisoccursin4%ofpatients.Nocasesofchoriocarcinomahavebeenreportedafterapartialmole,although4%ofpatientswithpartialmolesdeveloppersistentnonmetastatictrophoblasticdiseaserequiringchemotherapy.Race:Thereisnoracial/ethnicpredilectionformolarpregnancy.However,asdiscussedinthesectiononfrequency,Asiancountriesshowarate15timeshigherthantheUS.AsianwomenlivingintheUSdono

Hydatidiform mole (HM) is a rare mass or growth that forms inside the womb (uterus) at the beginning of a pregnancy. It is a type of gestational ...YouAreHere:Home→MedicalEncyclopedia→HydatidiformmoleURLofthispage://medlineplus.gov/ency/article/000909.htmHydatidiformmoleHydatidiformmole(HM)isararemassorgrowththatformsinsidethewomb(uterus)atthebeginningofapregnancy.Itisatypeofgestationaltrophoblasticdisease(GTD).CausesHM,ormolarpregnancy,resultsfromabnormalfertilizationoftheoocyte(egg).Itresultsinanabnormalfetus.Theplacentagrowsnormallywithlittleornogrowthofthefetaltissue.Theplacentaltissueformsamassintheuterus.Onultrasound,thismassoftenhasagrape-likeappearance,asitcontainsmanysmallcysts.Chanceofmoleformationishigherinolderwomen.Ahistoryofmoleinearlieryearsisalsoariskfactor.Molarpregnancycanbeoftwotypes:Partialmolarpregnancy:Thereisanabnormalplacentaandsomefetaldevelopment.Completemolarpregnancy:Thereisanabnormalplacentaandnofetus.Thereisnowaytopreventformationofthesemasses.SymptomsSymptomsofamolarpregnancymayinclude:Abnormalgrowthoftheuterus,eitherbiggerorsmallerthanusualSeverenauseaandvomitingVaginalbleedingduringthefirst3monthsofpregnancySymptomsofhyperthyroidism,includingheatintolerance, loosestools,rapidheartrate,restlessness ornervousness,warmandmoistskin,tremblinghands,orunexplainedweightlossSymptomssimilartopreeclampsiathatoccurinthefirsttrimesterorearlysecondtrimester,includinghighbloodpressureandswellinginthefeet,ankles,andlegs(thisisalmostalwaysasignofahydatidiformmole,becausepreeclampsiaisextremelyrarethisearlyinanormalpregnancy)ExamsandTestsYourhealthcareproviderwillperformapelvicexam,whichmayshowsignssimilartoanormalpregnancy.However,thesizeofthewombmaybeabnormalandtheremaybenoheartsoundsfromthebaby.Also,theremaybesomevaginalbleeding.Apregnancyultrasoundwillshowasnowstormappearancewithanabnormalplacenta,withorwithoutsomedevelopmentofababy.Testsdonemayinclude:hCG(quantitativelevels)bloodtestAbdominalorvaginalultrasoundofthepelvisChestx-rayCTorMRIoftheabd

A hydatidiform mole is a pregnancy/conceptus in which the placenta contains grapelike vesicles (small sacs) that are usually visible to the naked eye. The vesicles ...MolarpregnancyFromWikipedia,thefreeencyclopediaJumptonavigationJumptosearchAbnormalformofpregnancy(humandisorder)MolarpregnancyOthernamesVesicularmole,Hydatidmole,HydatidiformmoleHistopathologicimageofhydatidiformmole(completetype).H&Estain.SpecialtyObstetricsMolarpregnancyisanabnormalformofpregnancyinwhichanon-viablefertilizedeggimplantsintheuterusandwillfailtocometoterm.Amolarpregnancyisagestationaltrophoblasticdisease[1]whichgrowsintoamassintheuterusthathasswollenchorionicvilli.Thesevilligrowinclustersthatresemblegrapes.[2]Amolarpregnancycandevelopwhenafertilizedeggdoesnotcontainanoriginalmaternalnucleus.Theproductsofconceptionmayormaynotcontainfetaltissue.Itischaracterizedbythepresenceofahydatidiformmole(orhydatidmole,molahydatidosa).[3]Molarpregnanciesarecategorizedaspartialmolesorcompletemoles,withthewordmolebeingusedtodenotesimplyaclumpofgrowingtissue,oragrowth.Acompletemoleiscausedbyasinglesperm(90%ofthetime)ortwo(10%ofthetime)spermcombiningwithaneggwhichhaslostitsDNA.Inthefirstcase,thespermthenreduplicates,forminga"complete"46chromosomeset.[4]Thegenotypeistypically46,XX(diploid)duetothesubsequentmitosisofthefertilizingspermbutcanalsobe46,XY(diploid).[4]46,YY(diploid)isnotobserved.Incontrast,apartialmoleoccurswhenanormaleggisfertilizedbyoneortwospermwhichthenreduplicatesitself,yieldingthegenotypesof69,XXY(triploid)or92,XXXY(tetraploid).[4]Completehydatidiformmoleshavea2–4%riskofdevelopingintochoriocarcinomainWesterncountriesand10–15%inEasterncountriesanda15%riskofbecominganinvasivemole.Incompletemolescanbecomeinvasive(<5%risk)butarenotassociatedwithchoriocarcinoma.[4]Completehydatidiformmolesaccountfor50%ofallcasesofchoriocarcinoma.Molarpregnanciesarearelativelyrarecomplicationofpregnancy,makingup1in1,000pregnanciesintheUS,withmuchhigherratesinAsia(e.g.upto1in100pregnanciesinIndonesia).[5]Conte

A hydatidiform mole is growth of an abnormal fertilized egg or an overgrowth of tissue from the placenta. Women appear to be pregnant, but the uterus enlarges ...MSDManualPleaseconfirmthatyouarenotlocatedinsidetheRussianFederationYesNoLeavethisSite?Thelinkyouhaveselectedwilltakeyoutoathird-partywebsite.Wedonotcontrolorhaveresponsibilityforthecontentofanythird-partysite.ContinueCancelhoneypotlinkHOMEHEALTHTOPICSCommonHealthTopicsBloodDisordersBone,Joint,andMuscleDisordersBrain,SpinalCord,andNerveDisordersCancerChildren'sHealthIssuesDigestiveDisordersDisordersofNutritionDrugsEar,Nose,andThroatDisordersEyeDisordersFundamentalsHeartandBloodVesselDisordersHormonalandMetabolicDisordersImmuneDisordersInfectionsInjuriesandPoisoningKidneyandUrinaryTractDisordersLiverandGallbladderDisordersLungandAirwayDisordersMen'sHealthIssuesMentalHealthDisordersMouthandDentalDisordersOlderPeople’sHealthIssuesSkinDisordersSpecialSubjectsWomen'sHealthIssuesResourcesVideosFiguresImagesQuizzesCommonMedicalTestsViewAllResourcesSYMPTOMSGeneralAbdomen&DigestiveBleedingBrain&NervousSystemChest&RespiratoryChildren'sSymptomsEyeGenital&UrinaryALLSYMPTOMS>EMERGENCIESCardiacArrestChokingALLEMERGENCIES>RESOURCESAbbreviationsAudio3DModelsCommonMedicalTestsFiguresFirstAidImagesInfographicsLabTestMedicalTermsTheOne-PageManualofHealthPronunciationsQuizzesSelf-AssessmentToolsTablesVideosWeights&MeasuresNEWS'ZombieGenes'SpurSomeBrainCellstoGrowEvenAfterDeathAStressedBrainMightPlayRolein'BrokenHeart'SyndromeAHANews:HeartFailureat35HelpedNewYorkCardiologistBetterCareforPatientsAnIUDCouldWardOffEndometrialCancerinWomenatRiskViewAllNews>ViewAllNews>ABOUTOverviewHistoryEditorsandtheEditorialProcessPublishingandProductionStaffEditorialBoardContributorsReviewersContentProvidersGlobalMedicalKnowledgeFAQContactUsHealthTopics&ChaptersABCDEFGHIJKLMNOPQRSTUVWXYZHome/Women'sHealthIssues/CancersoftheFemaleReproductiveSystem/.../HydatidiformMole/INTHISTOPICTypesofgestationaltrophoblasticdiseaseSymptomsDiagnosisStagingProgn